44 results about "Carboxymethyl-beta-cyclodextrin" patented technology

The invention provides a preparation method of carboxymethyl-beta-cyclodextrin functionalized magnetic mesoporous silicon microspheres. The method includes the steps of: 1) preparing Fe3O4 via a coprecipitation method; 2) preparing SiO2-coated Fe3O4 particles (Fe3O4@SiO2), namely, magnetic silicon; 3) preparing mesoporous SiO2-coated Fe3O4@SiO2 particles (Fe3O4@SiO2@SiO2), namely, magnetic mesoporous silicon; 4) preparing carboxymethyl-beta-cyclodextrin (CM-beta-CD) via a wet process or a dry process; 5) preparing carboxymethyl-beta-cyclodextrin functionalized magnetic mesoporous silicon microspheres (Fe3O4@SiO2@SiO2-CM-beta-CD). In the invention, with Fe3O4 as an object, the functionalized magnetic mesoporous silicon microspheres are prepared through the coprecipitation method and Stobermethod, so that the method has simple processes and high-effective treatment, is low in cost, and supplies a new idea to preparation and application of magnetic adsorption microspheres. The product can improve effect of removing heavy metals in water by Fe3O4.

The invention discloses a modified bentonite adsorbent for removing copper in a polluted water body. A substance A is prepared by modifying cleaned bentonite with a mixed solution prepared from chitosan, acetic acid, carboxymethyl-beta-cyclodextrin, dimethyl sulfoxide, isopropanol and 2-(2,4-dichlorophenyl)-2-butyl-ethylene oxide; a substance B is prepared by modifying the substance A with a mixed solution prepared from SnCl4, AlCl3, Mn(NO3)2, and Co(NO3)2; a substance C is prepared by modifying the substance B with a mixed solution prepared from tetra-n-butyl titanate, octylmethyldiethoxysilane and tetramethyl bipropenyl triamine; and a substance, namely the modified bentonite adsorbent for removing the copper in the polluted water body, is obtained by modifying the substance C with a mixed solution prepared from acrylic acid, potassium persulfate, polyvinylpyrrolidone, 3-acryloyloxy propyl methyl dichlorosilane.

The invention discloses a preparation method of nano pesticide carboxymethyl-beta-cyclodextrin-Fe3O4-magnetic nano-diuron, the nano pesticide is a clathrate compound prepared from carboxymethyl-beta-cyclodextrin-Fe3O4-magnetic nanoparticles as a subject and object diuron by Van der Waals force, electrostatic attraction and the like. Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) show that carboxymethyl-beta-cyclodextrin is successfully grafted onto the surface of the Fe3O4 magnetic nanoparticles. Transmission electron microscopy analysis shows that the average particle size of the nano pesticide is 25 nm. The adsorption of the carboxymethyl-beta-cyclodextrin-Fe3O4-magnetic nanoparticles on the diuron is in line with the Langmuir isothermal adsorption curve. The new pesticide is good in water solubility and good in biocompatibility, has a slow release function, improves the pesticide utilization rate, extends pesticide efficacy preserving period, reduces the application amount and frequency, can be recycled, and reduces the harm of the pesticide on the environment.

The invention relates to a modified cyclodextrin-supported solid acid catalyst and application of the catalyst in the preparation of acetal/ketal. Modified cyclodextrin is polyethyleneimine modified carboxymethyl-beta-cyclodextrin; solid acid is selected from the group consisting of SO4<2->/ZrO2, CH3COO<->/ZrO2 and CH3SO3<->/ZrO2; and in the catalyst, a mass ratio of the modified cyclodextrin to the solid acid is 1: (0.1-10). A preparation method for acetal/ketal comprises a step of subjecting starting raw materials consisting of aldehyde/ketone and alcohol to a condensation reaction under theaction of a catalyst. The preparation method has the characteristics of high selectivity and indiscriminate reusability of unreacted raw materials and the unreacted catalyst. According to the invention, no other water absorbing agent is added, no other solvent is used, almost no by-product is produced, and high selectivity is realized; so the method is an environmentally-friendly novel method forsynthesizing acetal and ketal.

The invention discloses high-content stable prinsepia utilis royle oil microemulsion and a preparation method thereof, and belongs to the technical field of oil microemulsification. The prinsepia utilis royle oil microemulsion is prepared from 10-20 parts of prinsepia utilis royle oil, 3-7 parts of tween-65, 2-7 parts of span-80, 2-6 parts of sodium diethylhexyl sulfosuccinate, 3-7 parts of carboxymethyl-beta-cyclodextrin, 4-8 parts of cocamidopropyl betaine, 5-12 parts of glycerin, 2-4 parts of n-butyl alcohol, 0.1-0.3 part of a preservative and 130-160 parts of deionized water. The preparation method of the prinsepia utilis royle oil microemulsion comprises the steps of mixing, stirring, shearing and the like. The prepared prinsepia utilis royle oil microemulsion has the advantages of being small in particle size, good in storage stability property and excellent in dissolving property.

A carboxymethyl-beta-cyclodextin intercalated hydrotalcite for chiral resolving raceme is prepared through using LDHs as template to insert the carboxymethyl-beta- cyclodextrin anions in between the layers of hydrotalcite by ion change. Its chemical formula is also disclosed.

The invention discloses a method for detecting the content of methylene blue in blood plasma. The method comprises the following steps of: (a) adding carboxymethyl-beta-cyclodextrin saturated solution into blank blood plasma, enabling the concentration of the mixed solution to reach 1-4.5mmol/L and maintaining the constant volume to obtain a blood plasma blank sample; (b) adding quantitative methylene blue solution into the blank blood plasma and adding the carboxymethyl-beta-cyclodextrin saturated solution to obtain a standard blood plasma sample containing the methylene blue with the concentration of Cs; and (c) adding the carboxymethyl-beta-cyclodextrin saturated solution in a blood plasma sample containing the methylene blue to obtain a blood plasma to-be-measured sample containing the methylene blue with the concentration of Cs; detecting the strength or the area of a fluorescence peak of the sample; and then calculating according to a reference substance comparison method to obtain the concentration Cs of the methylene blue in the blood plasma to-be-measured sample. According to the method disclosed by the invention, the lowest detectable limit is 0.012mumol/L and the unexpected effect is obtained.

The invention discloses a supermolecular sensor array and a method for synchronously detecting paraquat and diquat. The sensor array comprises probes 1, 2 and 3, wherein the probe 1 is a solution prepared from safranine T and carboxymethyl-beta-cyclodextrin; the probe 2 is a solution prepared from methylene blue and carboxymethyl-beta-cyclodextrin; the probe 3 is a solution prepared from hematoxylin and carboxymethyl-beta-cyclodextrin. According to the supermolecular sensor array, multiple probes are combined into the sensor array; a fluorospectrophotometer is further combined to be capable of carrying out qualitative and quantitative analysis on two analytes at the same time; the method is simple and is accurate in result.

The invention relates to the field of organic-inorganic composites and in particular relates to a carboxymethyl-beta-cyclodextrin polymer intercalated hydrotalcite material and a preparation method thereof. The hydrotalcite material is prepared by the steps of preparing carboxymethyl modified beta-cyclodextrin intercalated cobalt-iron hydrotalcite, fully mixing the hydrotalcite and epichlorohydrin under the condition of strong alkaline, and then carrying out polymerization reaction on interlayer cyclodextrin and the epichlorohydrin to obtain the carboxymethyl-beta-cyclodextrin polymer intercalated hydrotalcite material. A chemical formula of the carboxymethyl-beta-cyclodextrin polymer intercalated hydrotalcite material is [(Co<2+>)1-x(Fe<3+>)x(OH)2]<x+>(CMCDP<n->)x/n.mH2O, wherein x is equal to 0.25-0.33, m is equal to 3-6 and is an amount of interlayer crystal water molecules, and n is equal to 25-50 and is an amount of negative charges carried by carboxymethyl-beta-cyclodextrin polymer. Compared with monomer cyclodextrin intercalated hydrotalcite, the carboxymethyl-beta-cyclodextrin polymer intercalated hydrotalcite has the advantages of more convenience, stronger stability, higher repeated utilization ratio, larger application range and the like. The preparation method is simple and feasible and is easy to realize.

The invention discloses a biodegradable sandy soil water-retention and fertilizer-retention agent, and relates to the technical field of water-retention and fertilizer-retention agents. The biodegradable sandy soil water-retention and fertilizer-retention agent is prepared from the following raw materials in parts by weight: 30-40 parts of carboxymethyl-beta-cyclodextrin, 15-20 parts of soil levelpolyglutamic acid, 10-15 parts of hydroxypropyl starch ether, 5-10 parts of activated clay, 5-10 parts of N-hydroxyethyl acrylamide, 1-5 parts of trimethylolpropane triglycidyl ether, 1-5 parts of superfine magnesium oxide, 0.5-2 parts of hydrolytic polymaleic anhydride, 0.5-2 parts of a maleic anhydride grafted compatilizer and 0.5-2 parts of hydrogenated castor oil. The prepared water-retentionand fertilizer-retention agent is suitable for water-retention and fertilizer-retention treatment on sandy soil, the problem of severe water and fertility loss in the sandy soil can be solved effectively, thus, normal growth of crops is ensured, and irrigation frequency and fertilizer application frequency are reduced.

The invention discloses a preparation method and application of a magnetic carboxymethyl beta-cyclodextrin polymer. The method comprises the following steps: 1) synthesis of a beta-cyclodextrin polymer; 2) synthesis of a carboxymethyl beta-cyclodextrin polymer; 3) synthesis of the magnetic carboxymethyl beta-cyclodextrin polymer. The magnetic carboxymethyl beta-cyclodextrin polymer wraps organic matters to form a host-guest complex with the organic matters so as to achieve the purpose of removing the organic matters, and is easy to prepare and recycle; when being applied to adsorb organic pollutants and heavy metals in the printing and dyeing wastewater, the polymer can effectively remove poisonous pollutants from the printing and dyeing wastewater, thereby having a high application valuefor effective control and recycling of the printing and dyeing wastewater. Moreover, the prepared polymer is magnetic, good in regeneration performance and reusable.

The invention provides a preparation method and an application of a magnetic carboxymethyl-beta-cyclodextrin polymer. The preparation method comprises the following steps: carboxylating beta-cyclodextrin, reacting the obtained carboxymethyl-beta-cyclodextrin with a crosslinking agent and a catalyst in a solvent to obtain a carboxymethyl-beta-cyclodextrin polymer, adding the carboxymethyl-beta-cyclodextrin polymer, trisodium citrate, tin(II) bis(2-ethylhexanoate), methanol, FeCl2.4H2O and FeCl3.6H2O into a three-necked flask according to a certain molar ratio, selecting 25% NH3.H20 as an alkalisource, and reacting obtained the system under the protection of nitrogen to obtain the magnetic carboxymethyl-beta-cyclodextrin polymer after the reaction is finished. Ferroferric oxide is successfully connected to the carboxymethyl-beta-cyclodextrin polymer by a coprecipitation technology, so the obtained polymer is magnetic, and can rapidly adsorb endocrine disrupting substances in the environment.

The invention provides a method for simultaneously carrying out chiral separation analysis on anisodamine, atenolol and metoprolol, which comprises the following steps: putting an anisodamine sample, an atenolol sample and a metoprolol sample in a sample cell of a capillary electrophoresis electrochemistry luminescence detection hyphenated instrument and applying an injection voltage to make the samples enter a capillary of the instrument; applying a separation voltage to make the samples carry out electrophoretic separation in the capillary, wherein the capillary is filled with separation solution comprising carboxymethyl-beta-cyclodextrin and the pH value of the separation solution is between 3.0 and 6.0; and making the separated samples enter a detection cell of the instrument and applying a detection voltage to carry out detection, wherein the detection cell is filled with detection solution comprising tris (bipyridine) ruthenium and the pH value of the detection solution is between 6.0 and 9.0. Compared with the prior art, the method for carrying out chiral separation analysis, which is provided by the invention, has the advantages of less reagent use, lower detection cost, higher separation efficiency and higher detection sensitivity.

The invention relates to a nano cyclodextrin composite additive reducing phenol in cigarette smoke. According to the nano cyclodextrin composite additive, with coconut shell charcoal for cigarettes as a carrier and carboxymethyl-beta-cyclodextrin and cationic polyelectrolyte as raw materials, the composite additive, with the surface loaded with cyclodextrin nano particles, of a micro-nano structure is obtained in an electrostatic drive in-situ growth mode. The cyclodextrin nano particles loaded in the composite additive are complex compounds of the carboxymethyl-beta-cyclodextrin and the positive-ion polyelectrolyte, and the mass percentage of the cyclodextrin nano particles loaded in the composite additive is 0.1%-10.0%. By adjusting the composition ratio of the carboxymethyl-beta-cyclodextrin to the cationic polyelectrolyte in the cyclodextrin nano particles, the reducing effect of the composite additive on the release amount of the phenol in the cigarette smoke can be conveniently regulated and controlled. The raw materials of the composite additive are convenient and easy to obtain and low in price, and a preparation method of the composite additive is environmentally friendly, safe and controllable and has good industrial applicability.

The invention discloses a method for preparing modified cyclodextrin based porous microspheres. According to the method, water serves as a reaction medium, an initiator is not needed, an oil phase, anemulsifier and other mixed solvents are also not needed, polyethylene glycol 600 serves as a stabilizer in the reaction system and also serves as a soft segment polymer for participating in the reaction, and the stabilizer does not need to be removed during later separating treatment. Compared with the conventional dispersion copolymerization method, the microsphere preparation method provided bythe invention is less in needed raw materials and assistants, simple in preparation and separation and low in production cost. In addition, according to the microsphere preparation method provided bythe invention, carboxymethyl-beta-cyclodextrin serves as a reactive monomer, and lots of ionizable groups exist in the system, so that enough surface charge can be provided under alkaline conditions.The dispersion can be assisted by utilizing the electrostatic repulsion mechanism, the stability is provided, and the microsphere product is endowed with more functionality (such as pH sensitivity).

The invention discloses preparation of a magnetically separable cyclodextrin organic phosphonic acid inclusion compound and an application of the inclusion compound in heavy metal ions in industrial wastewater. The method comprises the steps: adding Fe3O4 nanoparticles and sodium dodecyl benzene sulfonate to a NaOH solution dissolved with carboxymethyl-beta-cyclodextrin, and carrying out ultrasonic treatment to obtain a mixed solution; dropwise adding epoxy chloropropane to the mixed solution to obtain a reactant; carrying out magnetic separation of the reactant, and carrying out vacuum drying to obtain a product; and then carrying out ultrasonic dispersion of the product in deionized water, adding PBTCA, and continuing to carry out ultrasonic treatment for 4-6 h under a condition of room temperature, to obtain the cyclodextrin organic phosphonic acid inclusion compound. The magnetic nano material synthesized with Fe3O4 nanoparticles as a carrier can solve the problem successfully, the strong chelating effect of organic phosphonic acid can be used for collecting heavy metal ions in an aqueous solution, moreover, adsorbed magnetic nanoparticles can be rapidly removed from the solution under an action of an external magnetic field, the adsorption material can be conveniently and quickly recycled and reused, and at the same time, the inclusion compound has little influence on the environment, and is green and environmentally friendly.

Disclosed are a supermolecular kit and a method for quick detection of diquat. The supermolecular kit comprises a reagent 1 and a reagent 2, wherein the reagent 1 is a solution prepared from safranine T and carboxymethyl-beta-cyclodextrin, and the reagent 2 is a solution prepared from methylene blue and carboxymethyl-beta-cyclodextrin. The supermolecular kit is capable of detecting the diquat qualitatively through color matching by naked eyes and solves the problems about time and cost.

The invention relates to the technical field of composite materials, in particular to a preparation method of embedded resveratrol. The preparation method of the embedded resveratrol is characterizedby comprising the following steps that 1, a chloroacetic acid aqueous solution is added to a beta-cyclodextrin alkali solution to obtain a mixed solution, methanol is added to the mixed solution, precipitation is carried out, and carboxymethyl-beta-cyclodextrin is obtained; 2, a chitosan hydrochloride solution is mixed with the carboxymethyl-beta-cyclodextrin, a glutaraldehyde solution is dropwiseadded, and stirring is carried out to obtain a carboxymethyl-beta-cyclodextrin chitosan hydrochloride nano solution; 3, the carboxymethyl-beta-cyclodextrin chitosan hydrochloride nano solution is mixed with a resveratrol solution, and a mixed solution is adjusted to be neutral to obtain the embedded resveratrol. The preparing method of the embedded resveratrol solves the technical problem that anexisting method for embedding natural polyphenols is not suitable for massive industrial production and has many application limitations.

The invention discloses a composite instant black tea and a preparation method thereof. The main materials comprise, in parts by weight, 14-16 parts of black tea, 10-12 parts of herba lophatheri, 5-7parts of common bombax flowers, 3-5 parts of dried tangerine peel, 3-5 parts of Chinese wolfberry fruits and 2-4 parts of liquorice. The auxiliary materials comprise beta-cyclodextrin, glucose, threonine, L-tyrosine and L-phenylalanine, carboxymethyl-beta-cyclodextrin, maltodextrin and casein. The preparation method comprises the following steps: step 1, cleaning and weighing the main materials; step 2, conducting heating and extraction; step 3, carrying out ceramic membrane filtration on the extracting solution to obtain a filtrate; step 4, preparing microcapsules by adopting ultrasound; step5, conducting vacuum concentration; step 6, carrying out a Maillard reaction; and step 7, conducting freeze drying. According to the preparation method of the composite instant black tea, the obtained composite instant black tea is not only convenient to use, but also good in fragrance, good in color and rich in nutrients.

The invention belongs to the field of pharmaceutical preparations and in particular relates to liposome and a preparation method thereof. The liposome comprises a lipid double-molecule layer and an inner water phase, wherein the inner water phase contains carboxymethyl cyclodextrin and an active compound. The carboxymethyl cyclodextrin comprises carboxymethyl-alpha-cyclodextrin, carboxymethyl-beta-cyclodextrin and carboxymethyl-gamma-cyclodextrin. By adopting the liposome provided by the invention, the drug releasing speed of the active compound in the liposome can be improved.

The invention provides a carboxymethyl Beta-cyclodextrin functional montmorillonite supramolecular network material. According to the infrared spectroscopy generated by the material, absorption peaks are displayed at positions of 3421cm<-1>, 2934cm<-1>, 1637cm<-1>, 1414cm<-1>, 1159cm<-1>, 1087cm<-1>, 1039cm<-1>, 745cm<-1>, 613cm<-1>, and 587cm<-1>. The drug releasing system is prepared by using a CMCD-APTES-MMT supramolecular network as a carrier of berberine hydrochloride, the dispersing property and solubility of berberine hydrochloride in the water are obviously increased, and the bioavailability of berberine hydrochloride is effectively improved; compared with a drug carrier system taking montmorillonite as a carrier, the drug loading capacity is obviously improved, the local release amount is greatly improved, and the material has stronger antibacterial effect. The drug releasing system prepared by taking the CMCD-APTES-MMT supramolecular network as the carrier of berberine hydrochloride has very strong germ capturing ability; meanwhile, the CMCD-APTES-MMT supramolecular network also can envelope the germ thallus, so that the contact between the berberine hydrochloride loaded therein and germ is enhanced, and the antimicrobial property of berberine hydrochloride is improved.