The invention discloses lucid ganoderma-gingko wine, relating to the technical field of biological engineering. According to the wine provided by the invention, the alcoholic strength is 8-16%, the content of general flavone is 1-5 mg / L, the content of gingko lactone is 1-6 mg / L, the content of general terpenes compound is 30-800 mg / L, the content of protein is 60-200 mg / L, the content of ganoderic acid is 10-17 mg / L, the content of soluble sugar is 0-2.0%, the content of gingko phenolic acid is 0-5 ppm and the content of hydrocyanic acid is 0-0.1 microgram / liter. According to the preparationmethod provided by the invention, the gingko is hydrolyzed by utilizing a double-enzyme method to obtain a gingko hydrolyzing solution and the gingko hydrolyzing solution contains active compounds including gingko flavone, terpenes compounds, amino acid, peptides and starch and the like, wherein the content of the amino acid and the peptides is not less than 1% and the content of the starch is not less than 2%; the hydrolyzing solution is converted through lucid ganoderma strains and a rice mold culture is added to ferment to obtain fermentation liquor; the fermentation liquor is filtered andblended to obtain the lucid ganoderma-gingko wine. The wine provided by the invention contains the active components of the gingko and the lucid ganoderma and has the functions of preventing hypertension, resisting oxidization and the like.