221 results about "Thermo responsive" patented technology

The invention relates to materials comprising polymer network containing siloxanes or organic-based core structures, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to an organic core functionalized with polymers. In another embodiment, organic core-polymer conjugates comprise polylactone segments. The organic core-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments

A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having an amino acid side chain. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nanoparticle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.

A method of cleaning a fouled and/or scaled UF or MF membrane with a solution containing one or more thermo-responsive polymers is disclosed. More specifically, the method comprises: (a) treating the membrane in a membrane separation system with a solution containing one or more TRP, wherein said TRP is soluble in said solution and at least an effective amount of said TRP diffuses into a foulant layer that is present on the surface and/or in pores of said membrane; (b) making insoluble said TRP diffused into said foulant layer; (c) optionally rinsing the membrane; (d) optionally backwashing the membrane with air and/or liquid between the steps (b) and (c); and (e) optionally backwashing the membrane with air and/or liquid after the membrane is rinsed in step (c).

A fire protection sprinkler is provided. The sprinkler includes a body having an output orifice and a flange; a seal cap to seal a flow of fluid from the output orifice; and a thermally-responsive element positioned to releasably retain the seal cap and constructed to separate into a plurality of portions upon exposure to a predetermined temperature. The sprinkler also includes at least one deflector support member, a deflector connected to the deflector support member, and at least one arm extending from each of the deflector support members. Each of the arms has a free end positioned in spaced relation to the thermally-responsive element to contact the portions of the thermally-responsive element upon separation thereof. In another embodiment, the sprinkler includes at least one arm extending from the flange, and the arms may be formed as a bracket.

Disclosed is a temperature conditioning system including several thermal transfer blocks, where each is associated with one of several components requiring thermal management. Each of the components is associated with a different time dependent thermal management profile. A fluid path, with a heat transfer fluid, connects one or more transports to the thermal transfer blocks. For each thermal transfer block, at least one thermo-responsive valve is located downstream from the thermal transfer block. The thermo-responsive valve is passive in that it does not require energy other than thermal energy to move from a starting position to an ending position and the thermo-responsive valve is free of any exterior control lines. A method of temperature conditioning components is also disclosed including circulating a heat transfer fluid and optimizing the flow rate of the heat transfer fluid in response to differential changes in temperature of the heat transfer fluid by actuating one or more thermo-responsive valves.

The invention discloses a technical means for thermo-responsive hydrogel package delivery of exosomes and treatment effect enhancement. The technical means includes: wrapping stem cell derived exosomes with thermo-responsive hydrogel which is liquid at 4 DEG C, injecting to an injured part to form hydrogel with wrapped exosomes in vivo, and slowly releasing the exosomes to injured tissues. By adoption of the hydrogel, the retention rate and local concentration of the exosomes at the injured part can be increased while stability of functional molecular in the exosomes is improved, and the exosomes can be slowly released to the injured part to further improve treatment effects of the exosomes and promote structural and functional recovery of the injured tissues.

Described herein are thermo-responsive blends. Also described herein are articles, substrates, and kits composed of thermo-responsive blends for immobilizing cells or tissue and methods of use thereof.

The present invention relates to a thermo-responsive draw solute that can be applied to water desalination and purification based on forward osmosis. The thermo-responsive draw solute has a molar mass of 50 to 3000 g/mol and undergoes a phase transition at a temperature of 0° C. to 70° C. The thermo-responsive draw solute creates optimum conditions for the desalination of seawater and the purification of contaminated water based on forward osmosis. The present invention also relates to a method for water desalination and purification using the thermo-responsive draw solute. The method consumes little energy for water desalination or purification, is simple to apply to water desalination or purification, and enables separation of the draw solute in a very easy manner.

The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for biodegradable consumer plastics, adhesives, e.g., bioadhesives, pressure sensitive adhesives and thermos-responsive adhesives.

The invention belongs to the technical field of functional materials and particularly relates to a preparation method of stripping, functional modification and dual response intelligent composite gel of transition metal disulfide. A temperature-sensitive functional poly ionic liquid aqueous solution is used for ultrasonic stripping of transition metal disulfide powder, so that a nano layer laminated aqueous solution of the transition metal disulfide modified by polymer can be obtained directly; then a cross-linking agent is added so that intelligent gel with temperature and near-infrared dual response can be further prepared, and the intelligent gel can be taken as a shape memory material and an optothermal response intelligent gel material. The method is easy and convenient to operate, the production cost is low, batch production is easy, the prepared intelligent composite gel has multiple stimuli response, and the method can be applied widely and has large scale preparation potential and wide commercial application prospect.

The invention discloses multifunctional compound fabric and a production method thereof. The production method includes: performing oxygen plasma hydrophilic modification on commercial polypropylene fabric, then chemically plating the surface of the polypropylene fabric with a silver layer, spraying the mixed dispersion of Fe3O4 and PDMS to the surface of the sliver-plated fabric, and finally curing to obtain the multifunctional compound fabric. The multifunctional compound fabric has excellent electromagnetic shielding performance, super-hydrophobicity and electrothermal and photothermal responsiveness and can be applied to fields such as electromagnetic shielding garments in extreme environments, intelligent response fabric, photothermal conversion, electrothermal conversion or flexible wearable devices.

The invention discloses a method for preparing a photothermal conversion material on the basis of iodine doping. The equipment provided by the invention is based on doping preparation of black materials so as to realize the scaled processing of photothermal conversion materials and to further realize the three-dimensional stereoscopic modeling processing precise customized physical therapy, wherein used materials comprise industrial rubber (trans-polyisoprene), elemental iodine and various high molecular materials capable of realizing blending. Compared with a conventional photothermal conversion material, the photothermal conversion material obtained by the method of the invention has the advantages that simplicity is realized; the acquisition is easy; the large-scale production and processing can be realized; the modeling forming and processing can be realized; the operation is convenient; through the fine structure printing, the firm foundation is laid for the subsequent wide application; wide application prospects can be realized in the high-end customized personnel nursing market. Through the characteristic of easy blending with various materials, the application in aspects ofphotothermal conversion, further pyroelectricity and the like can be realized with the help of other thermal response materials; a novel idea is provided for solving the environment problems of hazeremoval and the like.

The invention belongs to the technical field of polymers and relates to a preparation method and an application of an amphiphilic thermo-responsive block copolymer. The amphiphilic thermo-responsive block copolymer comprises water-soluble PEG (polyethylene glycol) blocks and thermo-responsive PNIPAM (poly(N-isopropylacrylamide)) blocks. The thermo-responsive block copolymer material is prepared through steps as follows: firstly, trithio ester containing carboxyl is prepared and then subjected to esterification reaction with ethylene glycol monomethyl ether, a PEG macromolecular chain transferagent is prepared, finally, N-isopropyl acrylamide monomers are polymerized to the PEG macromolecular chain transfer agent through RAFT polymerization, and the thermo-responsive block copolymer with narrow distribution width index and proper lower critical solution temperature is synthesized. The prepared polymer has the advantages of narrow distribution width index, proper lower critical solutiontemperature and the like; the thermo-responsive block copolymer and organic salt establish a regenerative two-phase aqueous system, and the polymer has characteristics that split-phase temperature islow, operating conditions are mild, the polymer is easy to recycle and the like.

The present invention relates to a process for preparing copolymer hydrogels with controlled molecular weights and having both thermo- and pH-responsive properties, wherein the process comprises the steps of (a) providing sulfonamide type styrenic or (meth)acrylamide-based monomers exhibiting different pKa values; (b) providing poly(N-isopropylacrylamide) or crosslinked poly(N-isopropylacrylamide-co-methylene bisacrylamide) hydrogels having thermo-responsive properties; and (c) providing several hydrogels exhibiting pH-sensitive properties and random or block copolymerizations of the sulfonamide type styrenic or (meth)acrylamide-based monomers prepared in step (a) with N-isopropylacrylamide and/or methylene bisacrylamide monomers used in step (b) in a polar or non-polar solvent; wherein said steps (b) and (c) are carried out by controlled/living radical polymerization using alkyl halides as the initiators and the transition metals with phosphine or amine ligands as the catalysts. The present invention also relates to the copolymer hydrogels made by the aforesaid process.

The invention discloses a method for preparing stimuli-responsive porous aquagel. The method comprises the steps: uniformly mixing polymer monomers, an initiator, a cross-linker and water according toa preset mass ratio at the temperature of 0 DEG C to 4 DEG C, so as to obtain a precursor; subjecting the obtained precursor to freezing polymerization for 1 to 24 hours at the temperature of -40 DEGC to -10 DEG C, so as to obtain frozen gel; and subjecting the frozen gel to unfreezing polymerization for 1 to 24 hours at the temperature of 4 DEG C to 20 DEG C, thereby obtaining the stimuli-responsive porous aquagel. According to the method provided by the invention, freezing polymerization prior to unfreezing polymerization is employed, and the freezing condition is -40 DEG C to -10 DEG C, so that the rapid formation of ice crystals is facilitated, thus, the polymerization time is greatly shortened, and the production cost is reduced. Meanwhile, the obtained frozen gel is subjected to unfreezing polymerization for 1 to 24 hours at the temperature of 4 DEG C to 20 DEG C and is subjected to rapid cross-linking polymerization while the ice crystals melt, and thus, the elasticity and fatigue resistance of the aquagel are improved; and due to a porous effect after ice crystal melting, the thermal response characteristic and swelling ratio of the aquagel are improved.

The invention is directed to, inter alia, injectable materials, which comprise a a zero-length cross-linking agent encapsulated in a thermo-responsive liposome dispersed in a polymer solution where the polymer and cross-linking agent are segregated at a first temperature, and non-segregated at a second temperature, and the material is injectable at the first temperature. The invention is directed to, inter alia, processes for producing the material and use of the material for tissue repair and regeneration and controlled delivery of an agent are also described.

A method for preparing a solid composite material comprising a structural polymer matrix and a thermo-responsive hydrogel involves forming a substantially homogeneous blend of a cross-linkable compound and monomer, oligomer or polymer particles in a blended aqueous liquid, inducing the cross-linkable compound to cross-link to form the thermo-responsive hydrogel and forming the structural polymer matrix from the structural polymer by a further induction means.

A pharmaceutical composition for intraperitoneal delivery of an anti-neoplastic agent is provided for treating cancers associated with aberrant mucin expression, preferably ovarian cancer and pancreatic, prostate, metastatic breast, bladder and lung cancers. The composition comprises nanomicelles loaded with the anti-neoplastic agent, and antibodies such as anti-MUC16, anti-MUC1 or anti-MUC4 are conjugated to these nanomicelles. The antibody-bound nanomicelles are optionally embedded in a biodegradable pH- and thermo-responsive hydrogel capable of sol-gel transition at body temperature. The pharmaceutical composition is implantable in the peritoneum, where it transforms into a semi-solid gel at the body's core temperature. In response to pH, the hydrogel swells and releases the antibody-bound nanomicelles. The nanomicelles specifically target mucin antigens on cancer cells. The anti-mucin antibodies can be internalized by the tumour cells, enabling the drug-loaded nanomicelles to gain entry and deliver the chemotherapeutic drugs inside the tumour cell.

The invention relates to an intelligent micro valve based on a micro-fluidic chip and a production method thereof. Microstructures and micro-channels are arranged on the surface of the micro-fluidic chip, a hydrophilic/dehydrophilic gate controlled switch is arranged on a main micro-channel, the surfaces of the micro-channels are modified through thermo-responsive molecules, reversible changes of surface appearance and chemical construction of the micro-channels cause changes of surface invasion under stimulation of external field temperature, movement of micro-fluid on the surfaces of the micro-channels is controlled, and therefore the intelligent micro valve achieves control on micro-fluid flowing. The intelligent micro valve is mainly applied to the related fields such as electrophoretic separation, chromatographic separation and immunoassay, achieves intelligent driving and control on micro-fluid, greatly reduces micro-fluid driving and control cost, has the advantages of being portable, economical, fast and efficient, and is a novel analysis technique for micro-fluid driving and control.