The invention relates to a BCC-based high-strength, high-entropy and high-temperature alloy for coherent precipitation of cubic nano particles, and belongs to the technical field of new materials. Thealloy comprises Fe, Co, Ni, Mn, Cr, Mo, Nb, Ta, Al, Ti and Zr, and the atomic percentage expression of the alloy composition is Alx(Ti, Zr)y(Nb, Ta)z(Cr, Mo, Fe)m(Co, Ni)n, where x=5-18%, y=0-55%, z=0-55%, m=0-60%, n=0-40%, and x+y+z+m+n=100%. The material performance indexes are: tensile strength Sigma b=1200-2150 MPa, and hardness HV=550-650 at room temperature; Sigma b=350-900 MPa, and HV=120-350 at 700 DEG C; Sigma b=200-450 MPa, and HV=70-200 at 1000 DEG C. According to the BCC-based high-strength, high-entropy and high-temperature alloy provided by the invention, through composition design, the organization and control of the coherent precipitation of BBC/B2 cubic particles are achieved, so that the maximum improvement of the alloy strength is ensured, and the high-temperature strength, creep resistance, oxidation resistance and corrosion resistance of the alloy are improved. The alloy is a kind of novel high-temperature alloy.