A harmless processing comprehensive utilization technology for life garbage is mainly used for solving the technical problems such as non-environmental protection of prior life garbage processing manner. The technical proposal mainly comprises the following steps of: separating and screening raw life garbage to separate recyclable waste materials such as paper, plastic and heavy metals for recycling and reusing, and combustible materials such as plants and waste clothes for burning in a burner; and then crushing the rest garbage, sieving, sorting, adding active bacteria, stirring completely, feeding into a high-temperature fermenter, and fermenting to obtain organic fertilizer and nutrient soil. According to the invention, the full process for processing the life garbage including fermenting, decomposition, deodorization, sterilization, purification, concentration and discharge only takes 18 to 30 hours, the volume of the waste materials can be reduced by about 30% to 70%, and high-quality organic fertilizer and nutrient organic substrate excellent in color, odor and nutrient can be produced. The process is energy-saving and environment-friendly, and can be widely used to process and reuse the life garbage.