The application provides a nanoscale photothermal
electric coupling energy platform and a preparation method and application thereof, and belongs to the technical field of nanobiomedical materials. The method comprises the following steps: dispersing ZIF-8 particles in an
alcohol solvent of
silver nitrate, introducing
metal silver ions through
ion exchange and / or adsorption; dispersing the ZIF-8 material loaded with
metal silver ions in an
alcohol solvent, dropping a
selenium precursor solution prepared by dissolving a
sulfide and elemental
selenium powder in an
organic solvent together, and generating uniformly distributed
metal silver
selenide nanoparticles in the
confined space of ZIF-8 in situ. The obtained product is composed of a ZIF-8 carrier and uniformly dispersed metal silver
selenide semiconductor nanoparticles, has a particle size of 300+ / -20 nm, and has a photothermal electric effect. The energy platform can be combined with a biocompatible matrix to form a flexible patch, a film or a
coating, can promote
cell proliferation, migration, collagen deposition or
recovery of mitochondrial function, and is particularly suitable for treating diabetic
skin wounds.