The invention discloses nickel base alloy clad steel plates for a pipeline. Each nickel base alloy clad steel plate comprises a nickel base alloy layer and a carbon steel layer. Each carbon steel layer comprises, by mass percentage, 0.01-0.20% of C, 0.10-0.5% of Si, 0.5-2.0% of Mn, at least one of less than or equal to 0.10% of V, less than or equal to 0.10% of Nb, less than or equal to 0.02% of Ti, less than or equal to 0.50% of Ni, less than or equal to 0.5% of Cu, less than or equal to 0.50% of Cr and less than or equal to 0.3% of Mo, and the balance Fe and inevitable impurities. The invention further discloses a manufacturing method of the nickel base alloy clad steel plates for the pipeline. The method comprises the steps that 1, a carbon steel blank and a nickel base alloy blank are obtained; 2, the blanks are assembled through a symmetrical splitting method; 3, composite rolling is conducted, and two sets of double-layer clad steel plates are obtained; and 4, air cooling or water cooling is conducted after rolling till the room temperature is reached, or solid solution treatment is conducted.