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44 results about "Bromelains" patented technology

A prebiotic feed additive for promoting intestinal health of pigs and preparation method thereof

The present invention relates to a prebiotic feed additive for promoting intestinal health of pigs, belonging to the technical field of feed, the prebiotic feed additive of the present invention comprises prebiotic components and biological adjuvants, the prebiotic components comprise oligofructose, oligoisomaltose, inulin and resistant dextrin, the biological adjuvant is a product obtained by co-enzymatic hydrolysis of dandelion and houttuynia cordata by hemicellulase and pectinase, then fermented by Lactobacillus acidophilus and Propionibacterium freudenreichii in sequence, and finally enzymatic hydrolyzed by bromelain and trypsin step by step. The components in the additive are used in combination to have a good effect of promoting intestinal health of pigs, can balance and improve the intestinal microenvironment, improve feed nutrient utilization, enhance immunity, reduce diarrheal diseases, and promote growth and weight gain.
Owner:TIANJIN MODERN TIANJIAO AGRI TECH CO LTD

Medicine for skin regeneration and repair and preparation method thereof

The invention relates to a medicine for skin regeneration and repair and a preparation method thereof, and belongs to the technical field of biological medicine, the medicine comprises cyperus esculentus extract peptide, brooklet anemone root tremella extract, rhodomyrtus tomentosa root-suberect spatholobus stem-radix cyathulae composite extract, pomegranate peel polyphenol and the like. The cyperus esculentus extracted peptide is a product which is more than 1kDa and is obtained by performing enzymolysis on cyperus esculentus through cellulase, alpha-chymotrypsin and ficin protease in sequence and then performing purification through a G-50 sephadex column; the tremellodon gelatinosum tremella extract is a product which is less than 3kDa and is obtained by performing common enzymolysis on tremellodon gelatinosum tremella sporocarp through cellulase and bromelain; the rhodomyrtus tomentosa root-suberect spatholobus stem-radix cyathulae composite extract is a product obtained by performing gradient extraction on rhodomyrtus tomentosa root, suberect spatholobus stem and radix cyathulae through an ethanol water solution to obtain an extract, and performing polyamide resin column adsorption and LH-60 sephadex column purification in sequence. A good repairing system is constructed by multiple components, and wound repairing and healing are accelerated.
Owner:HUBEI SHUANGXING PHARMA CO LTD

Modified hydroxytyrosol as well as preparation method, cosmetics and application thereof

The invention discloses modified hydroxytyrosol as well as a preparation method, cosmetics and application thereof. The provided preparation method of the modified hydroxytyrosol comprises the following steps: in the presence of an acidic solvent, hydroxytyrosol and bromelain are mixed for an enzymatic hydrolysis reaction, and the modified hydroxytyrosol is prepared. According to the provided preparation method of the modified hydroxytyrosol, the hydroxytyrosol is subjected to catalytic modification through bromelain, bromelain serves as typical sulfydryl protease and is subjected to an enzymolysis reaction with the hydroxytyrosol, the hydroxytyrosol enzymolysis derivative is generated, and the generated hydroxytyrosol enzymolysis derivative contains various substances with aromatic smells, so that the hydroxytyrosol can be used for preparing the modified hydroxytyrosol. The obvious pungent smell of the hydroxytyrosol raw material is effectively improved.
Owner:BEIJING QINGYAN BOSHI HEALTH MANAGEMENT CO LTD

Preparation method of low-sensitization hydrolyzed whey protein nano-scale microcapsule powder

The invention relates to the technical field of food, in particular to a preparation method of low-sensitization hydrolyzed whey protein nanoscale microcapsule powder, which comprises the following steps: S1, preparing a whey protein solution, performing microfiltration, and treating with cysteine hydrochloride; s2, trypsin hydrolysis; s3, inactivating and cooling; s4, adding chymotrypsin, and synchronously applying ultrasonic waves; s5, bromelain is added, ultrafiltration is performed, and peptide fragments are collected; s6, preparing a capsule wall solution; s7, adopting a micro-fluidic chip to form a nano emulsion; s8, the mixture is added into a CaCl2 solution to be stirred, multi-layer self-assembly is conducted, and micro-capsule particles are obtained; and S9, carrying out ultrahigh-pressure micro-jet homogenization, vacuum freeze drying and low-temperature plasma assisted grinding on the micro-capsule particles to obtain the nano-scale micro-capsule powder. The stability of active ingredients is maintained through multi-enzyme cooperation and ultrasonic-assisted efficient elimination of allergens, multi-layer nano-embedding under microfluidic control and low-temperature plasma grinding, and the limitations of low single enzymolysis efficiency, insufficient embedding rate and thermal denaturation risk in the prior art are overcome.
Owner:OCEAN UNIV OF CHINA +1

Enamel repairing toothpaste and preparation method thereof

The invention provides tooth enamel repairing toothpaste and a preparation method thereof, and the tooth enamel repairing toothpaste comprises the following components in percentage by mass: 15-30% of glycerol, 15-30% of glycerol, 5-10% of sodium dodecyl sulfate, 5-10% of sodium dodecyl sulfate, 5-10% of sodium dodecyl sulfate and the balance of deionized water. 10%-25% of hydrated silica; 3%-10% of polyethylene glycol-8; 3%-7% of calcium phosphosilicate; 1%-5% of a surfactant; 0.5%-3% of a binder; 0.05%-0.5% of an antibacterial agent; 0.1%-1.5% of a compound enzyme; the compound enzyme comprises lysozyme, papain and bromelain; the mass ratio of the lysozyme to the papain to the bromelain is 1: (0.4-0.6): (0.4-0.6); and the balance of water. The toothpaste can be used for remarkably improving the repairing effect of enamel and the oral health maintenance capability.
Owner:ZUODIAN IND (HUBEI) CO LTD

Bromelain composition for treating cow mastitis and application of bromelain composition

The invention discloses a bromelain composition for treating cow mastitis and application of the bromelain composition, and belongs to the technical field of biological medicine. The composition is prepared by compounding the following components in parts by weight: 1-20 parts of bromelain, 1-20 parts of cystine and 1-20 parts of sodium gluconate. 4 to 40 parts of cystine; and 0.2 to 2 parts of sodium gluconate. The bromelain composition has the effects of diminishing swelling, dispersing blood stasis, clearing heat, detoxifying, diminishing inflammation and the like, and is small in toxic and side effects, not easy to generate drug resistance, high in bioavailability, high in curative effect on cow mastitis caused by pathogenic bacteria infection, free of residues, free of drug resistance, green and safe. The bromelain composition for treating cow mastitis can reduce the number of somatic cells in cow's milk with mastitis and the content of ALP, NAG and LDH in cow's milk and cow's serum in a short time, and has a good treatment effect on cow mastitis.
Owner:NANNING PANGBO BIOLOGICAL ENG CO LTD

Bromelain freeze-drying protective agent and preparation method thereof

The invention belongs to the technical field of biological enzyme preservation, and particularly relates to a bromelain freeze-drying protective agent and a preparation method thereof. The trehalose and pulullan compound freeze-dried powder injection is prepared from the following components in parts by weight: 30 to 50 parts of trehalose, 8 to 10 parts of pulullan, 3 to 10 parts of maltodextrin, 12 to 22 parts of mannitol, 1 to 4 parts of sorbitol, 4 to 12 parts of glycine, 0.05 to 0.2 part of polysorbate-20, 1.5 to 4.5 parts of a buffering agent, 0.2 to 0.8 part of N-acetylcysteine, 0.05 to 0.3 part of oxidized glutathione, 0.8 to 2.5 parts of PEG (Polyethylene Glycol) and 0.05 to 0.3 part of an antioxidant. According to the invention, trehalose-pullulan is taken as a main skeleton, so that the growth of ice crystals is inhibited, and the water activity is reduced; mannitol constructs a crystal phase support network, and polysorbate-20 stabilizes an interface; sulfydryl is temporarily sealed through oxidized glutathione, and controllable reduction during redissolution is realized through microencapsulated N-acetylcysteine; and a sodium phosphate buffer system keeps the pH stable.
Owner:SUZHOU POLYTECHNIC INST OF AGRI +1

A freeze-drying protective agent for bromelain and a method for preparing the same

The present application belongs to the technical field of biological enzyme preservation, and particularly relates to a bromelain freeze-drying protective agent and a preparation method thereof. The composition comprises the following components: 30-50 parts of trehalose, 8-10 parts of pullulan, 3-10 parts of malt dextrin, 12-22 parts of mannitol, 1-4 parts of sorbitol, 4-12 parts of glycine, 0.05-0.2 parts of polysorbate-20, 1.5-4.5 parts of a buffer, 0.2-0.8 parts of N-acetylcysteine, 0.05-0.3 parts of oxidized glutathione, 0.8-2.5 parts of PEG and 0.05-0.3 parts of an antioxidant. The present application takes trehalose-pullulan polysaccharide as a main skeleton, inhibits ice crystal growth and reduces water activity; mannitol constructs a crystal phase support network, and polysorbate-20 stabilizes the interface; oxidized glutathione temporarily seals mercapto groups, and microencapsulated N-acetylcysteine realizes controllable reduction during redissolution; and a sodium phosphate buffer system maintains pH stability.
Owner:SUZHOU POLYTECHNIC INST OF AGRI +1

Production method of salt roasted chicken accessory tenderized by compound protease

The invention discloses a production method of a salt roasted chicken accessory tenderized by compound protease, particularly relates to the technical field of food processing, and relates to a production method of a salt roasted chicken accessory tenderized by compound protease. The salt roasted chicken accessory tenderized by the compound protease is prepared from chicken accessories, papain, bromelain, neutral protease, crude sea salt, kaempferia galanga powder and star anise powder. The salt roasted chicken accessory tenderized by the compound protease is prepared from the following raw material components in parts by weight: 100 parts of chicken accessories, 0.2-0.4 part of papain, 0.1-0.3 part of bromelain, 0.1 part of neutral protease, 1.0-1.5 parts of crude sea salt, 0.6-1.2 parts of kaempferia galanga powder and 0.3-0.8 part of star aniseed powder. The papain, the bromelain and the neutral protease are compounded, specific decomposition is performed on different proteins in the chicken meat, the chicken meat characteristics of different chicken accessories are adapted, and the tenderization degree of the chicken accessories is improved.
Owner:GUANGDONG HAOWEILAI FOOD CO LTD

Method for extracting bromelain by ultrasonic-assisted deep-eutectic solvent

The invention belongs to the field of food science and engineering, and discloses a method for extracting bromelain by using an ultrasonic-assisted eutectic solvent. The method for extracting bromelain by using the ultrasonic-assisted deep-eutectic solvent comprises the following steps: heating and mixing a hydrogen bond acceptor and a hydrogen bond donor to obtain a deep-eutectic solvent, adding water, and uniformly mixing to obtain a deep-eutectic extracting agent; and then adding the pineapple peel powder into the eutectic extractant, and carrying out ultrasonic extraction to obtain bromelain. The highest enzyme activity of the bromelain can reach 1000U / mg or above, under the condition that the highest enzyme activity is obtained, the protein content of the bromelain reaches 10g / kg or above, and high purity is kept.
Owner:SOUTH CHINA UNIV OF TECH

A method for preparing high purity ecdysone from morningglory

ActiveCN117285584BSteroidsPectinaseCellulase
The present application relates to a kind of methods for preparing high-purity ecdysone from dew grass, comprising (1) pretreatment, (2) enzymolysis, the complex enzyme includes cellulase, pectinase, papain and bromelain;(3) extraction, (4) purification: dew grass extract is passed through macroporous adsorption resin, sequentially using alkali washing, one water washing, acid washing, twice water washing, ethanol elution, concentration;(5) bleaching, (6) crude crystallization, (7) recrystallization.The purity and yield of β-ecdysone product obtained by the method of the present application are high, and the composite enzyme enzymolysis is combined with ultrasonic countercurrent extraction, which can efficiently and quickly extract;During the purification process, low-concentration alkali washing and acid washing can effectively elute impurities, improve the purity of β-ecdysone, and also reduce the difficulty of macroporous resin regeneration, improve production efficiency.The method of the present application is simple, and the resin and solvent used can be reused, with low process cost, suitable for industrial production.
Owner:HUNAN HUACHENG BIOTECH INC

Marine bioactive protein peptide and application thereof in fresh keeping of chicken

The invention provides a marine bioactive protein peptide and application thereof in fresh keeping of chicken. The application of the marine bioactive protein peptide in fresh keeping of chicken comprises the following steps: S1, cutting chicken breast into blocks; s2, performing enzymolysis on the shrimp meat with bromelain and chymotrypsin, performing centrifugation, and adding lactic acid into supernate to prepare marine bioactive protein peptide; s3, adding the marine bioactive protein peptide into the hydroxypropyl methyl cellulose solution to prepare a fresh-keeping solution loaded with the marine bioactive protein peptide; and S4, soaking the blocky chicken breast in a fresh-keeping solution, taking out, draining, performing vacuum packaging, and performing cold storage. The fresh-keeping liquid loaded with marine bioactive protein peptides is used for keeping the chicken breast fresh, the oxidation process of chicken is delayed, water loss is remarkably reduced, and the sensory quality of chicken is kept.
Owner:DEZHOU JIANGSHENG FOOD

Asymmetric phosphorus-containing dendrimer carrying aza-bisphosphonate terminal, compound as well as preparation and application of asymmetric phosphorus-containing dendrimer and compound

The invention relates to an asymmetric phosphorus-containing dendrimer carrying an aza-bisphosphonate terminal, a compound and preparation and application of the asymmetric phosphorus-containing dendrimer, the asymmetric phosphorus-containing dendrimer has the characteristics of uniform molecular weight, simple preparation method, high reaction process controllability, easiness in operation and separation and the like, the intracellular delivery efficiency of bromelain can be enhanced, and the yield of bromelain is increased. The inflammatory factor storm is controlled by synergistically regulating the macrophage phenotype, the cartilage cell protection function is played, and good development prospects and application values are achieved in treatment of osteoarthritis patients.
Owner:DONGHUA UNIV

Light-operated genetically engineered bacterium backpack and application thereof

The invention relates to a light-operated genetically engineered bacterium knapsack and application thereof, and belongs to the technical field of genetic engineering and biological medicine crossing, the genetically engineered bacterium knapsack comprises an engineered bacterium, and the engineered bacterium is prepared by transferring a recombinant plasmid expressing a chemotactic factor CCL21 and a recombinant plasmid expressing cleavage protein into an initial strain escherichia coli; the surface of the engineering bacterium is modified with bromelain and PGA-DA-Cys. The genetically engineered bacterium knapsack can be anchored on the surface of macrophages so as to target tumor tissues, and the genetically engineered bacterium knapsack can significantly activate immune response of tumor parts so as to achieve a tumor immunotherapy effect.
Owner:ZHENGZHOU UNIV +1

Preparation method of full-component pearl hydrolysate, pearl hydrolysate and application

The invention discloses a preparation method of full-component pearl hydrolysate, which comprises the following steps: S1, mixing pearl powder with distilled water, adding protease, carrying out enzymolysis reaction, and filtering to obtain enzymatic hydrolysate; and S2, adding an acidic material into the enzymatic hydrolysate, carrying out acidolysis reaction, adjusting the pH value to 6-7, and filtering to obtain the pearl hydrolysate. According to the invention, bromelain is adopted to carry out enzymolysis at 50 DEG C for 150 minutes under the addition amount of 30wt%, so that the obtained pearl hydrolysate has the highest amino acid content and the best hydrolysis effect. By adopting a hydrolysis method of firstly carrying out enzyme hydrolysis and then carrying out acid hydrolysis, the obtained pearl hydrolysate has high amino acid content, is easily absorbed and used by a human body, is combined with active components of other skin care products for use, and has relatively high stability. The application range of the pearl hydrolysate is expanded, and the using effect after application is optimized.
Owner:GUANGZHOU AURORA BOREALIS BIOTECHNOLOGY CO LTD

Preparation method of rhodomyrtus tomentosa fruit extract and product and application of rhodomyrtus tomentosa fruit extract

The invention relates to a preparation method of a rhodomyrtus tomentosa fruit extract as well as a product and application of the rhodomyrtus tomentosa fruit extract. The preparation method comprises the following steps: mixing a rhodomyrtus tomentosa fruit raw material with a compound enzyme for enzymolysis, adding an ethanol aqueous solution into an enzymolysis reaction solution after enzymolysis is completed, performing negative pressure cavitation extraction, filtering and collecting filtrate to obtain the rhodomyrtus tomentosa fruit extract, the compound enzyme comprises a combination of cellulase, bromelain, alpha-amylase and tannase. According to the method, the effective components in the longan pulp are extracted by adopting the specific compound enzyme, the related components in the rhodomyrtus tomentosa fruits can be efficiently extracted, a potential synergistic relationship exists among bromelain, alpha-amylase and tannase, the extraction effect can be remarkably improved after the bromelain, the alpha-amylase and the tannase are combined, and the method is suitable for industrial production. The prepared extract product has the effects of resisting inflammation, relieving, resisting oxidation and the like.
Owner:GUANGDONG MARUBI BIOLOGICAL TECH CO LTD

Preparation method of immunoglobulin powder and application thereof

PendingCN122255259Aresolve failureretain activityPowder deliveryMilk immunoglobulinsMilk SerumIntravenous gammaglobulin
The present application relates to a kind of preparation method of immunoglobulin powder and its application, the preparation method includes the following steps: collecting bovine colostrum, using cell survival technology is frozen;Frozen bovine colostrum is thawed, carries out milk fat separation, and obtains defatted bovine colostrum;Defatted bovine colostrum and composite rennet are mixed and are curdled, and then broken, obtain whey;The composite rennet includes aspartic protease, papain and bromelain;Whey is ultrafiltrated, and immunoglobulin solution is obtained;Immunoglobulin solution is vacuum freeze-dried, and the immunoglobulin powder is obtained.The preparation method provided by the present application is low temperature all the way, the activity of immunoglobulin is retained to the greatest extent, the use of composite rennet solves the problem of curd failure, and each link cooperates to improve the curd effect, realizes the preparation of high-efficiency, high-purity and high-quality immunoglobulin powder.
Owner:INNER MONGOLIA MENGNIU DAIRY IND (GROUP) CO LTD

Method for treating and / or improving inflammatory intestinal disease

A method for treating and / or improving inflammatory intestinal disease includes administering a composition to a patient suffering from inflammatory intestinal disease to be capable of effectively inhibiting the patient's intestinal bleeding, intestinal inflammation, and capable of achieving efficacies of repairing intestinal cells and intestinal wall structure. The composition contains an effective amount of bromelain and / or an effective amount of Bidens pilosa extract.
Owner:TUNGHAI UNIVERSITY

Efficient tenderization method for livestock and poultry byproducts

The invention belongs to the technical field of livestock and poultry by-product processing, and particularly relates to an efficient tenderization method for livestock and poultry by-products. The method comprises the following steps: preparing a papain solution and a bromelain solution by taking natural small molecule water as a solvent, and tenderizing the livestock and poultry byproducts by adopting the papain solution and the bromelain solution. Natural small molecule water is used for dissolving papain and bromelain for directional efficient tenderization, the problem of processing quality of livestock and poultry byproducts can be solved, and uniformity of internal and external taste of the byproducts is effectively achieved.
Owner:HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY +3

Whey protein peptide with high anticoagulant activity and blood fat reducing effect and preparation method thereof

The invention discloses a whey protein peptide with high anticoagulant activity and a blood fat reducing effect and a preparation method thereof. The preparation method comprises the following steps: firstly carrying out pulsed electric field pretreatment on a whey protein aqueous solution, then hydrolyzing the pretreated whey protein aqueous solution by using bromelain, and freeze-drying to obtain the whey protein peptide. According to the method, bromelain is selected to carry out enzymolysis on the whey protein aqueous solution, and the whey protein aqueous solution is pretreated by using the pulsed electric field before enzymolysis, so that the use of the pulsed electric field is beneficial to promoting the exposure of peptide chain segments with anticoagulation and blood fat reduction functions, and the anticoagulation and blood fat reduction capabilities of the whey protein peptide are remarkably improved. The method breaks through the limitation of the traditional process, and overcomes the problems of low efficiency and limited active peptide release of a single enzymolysis method through the synergistic effect of the pulsed electric field pretreatment and the enzymolysis technology. The non-thermal effect of the pulsed electric field can directionally change the space structure of the whey protein, more enzyme cutting sites are exposed, and meanwhile protein denaturation caused by high-temperature treatment is avoided.
Owner:NINGBO UNIV

Toothpaste and preparation method thereof

The invention discloses toothpaste and a preparation method thereof. The toothpaste is prepared from components in percentage by mass as follows: 8%-15% of bamboo salt, 0.03%-0.15% of o-cymene-5-alcohol, 1%-5% of polyglycerol fatty acid ester, 0.5%-3% of calcium salt, 0.05%-0.3% of lysozyme, 0.2%-1% of bromelain, 15%-28% of a friction agent, 0.4%-1.2% of a thickening agent, 0.1%-2% of a pH buffer system, 10%-35% of a humectant, 1.5%-4% of a foaming agent and the balance of water. Glycyrrhizic acid is replaced by polyglycerol ester / calcium ion micelles, so that the problem of IPMP inactivation is thoroughly solved while the pH conflict is avoided.
Owner:ZUNYI MEDICAL UNIVERSITY

Method for efficiently extracting bromelain based on magnetic chitosan microspheres

The invention discloses a method for efficiently extracting bromelain based on magnetic chitosan microspheres, and relates to the technical field of biochemical engineering, and the method comprises the following steps: preparation of magnetic chitosan microspheres, extraction of bromelain, and purification and detection of bromelain. According to the preparation method disclosed by the invention, the magnetic chitosan microspheres with excellent performance are prepared by performing surface modification on the nanoscale ferroferric oxide particles and accurately controlling glutaraldehyde reaction and ultrasonic dispersion, and the adsorption performance is improved by 60%. The microspheres are used for specifically adsorbing bromelain, the extraction efficiency is improved by more than 30% in combination with optimized conditions, the operation time is shortened by 50% through magnetic separation, and the cost is reduced. An adsorption mechanism is defined, conditions are optimized, and the purity of bromelain is improved by 20% or above. A protective agent is added during adsorption and desorption, the retention rate of enzyme activity reaches 90% or above, the product quality and the application value are guaranteed, the application range is expanded, and good application prospects and economic values are achieved.
Owner:GUANGDONG OCEAN UNIVERSITY

A method for preparing and using a bromelain composition

The application provides a preparation method and application of a bromelain composition, and belongs to the technical field of biotechnology.The composition contains bromelain, superoxide dismutase, amino acids and complex polysaccharides extracted from aloe, sturgeon collagen peptide and hamamelis extract; the aloe amino acid polysaccharide, sturgeon collagen peptide and hamamelis extract are high-efficiency products obtained through special enzymolysis or fermentation and purification. The various components are used in combination, can remove dead skin cells, remove wrinkles, keep the skin firm and elastic, have good whitening and anti-wrinkle effects, and have few component types, do not cause absorption burden to the skin, and are safe and efficient.
Owner:广州柏为科技有限公司

A quercetin-eucalyptus oil composition for clearing and protecting the lungs

PendingCN122439875ABiotechnologyPerillaldehyde
The application discloses a quercetin-eucalyptus oil composition for clearing and protecting lungs, and relates to the technical field of functional food. The composition comprises an active functional component and a three-phase layered targeting delivery system. The active functional component is composed of quercetin 5-20 parts, eucalyptus oil 1-8 parts, bromelain 2-10 parts, dihydromyricetin 10-30 parts, perillaldehyde 1-6 parts, icariin 3-15 parts and ultralow-molecular-weight sodium hyaluronate 1-5 parts in terms of weight fraction. The three-phase layered targeting delivery system comprises three independent embedding units, namely enteric-soluble protective microspheres for wrapping bromelain, nano-mixed micelles for wrapping quercetin, dihydromyricetin and icariin, and slow-release microcapsules for wrapping eucalyptus oil and perillaldehyde. The application solves the problems of component compatibility conflict and component inactivation in traditional compositions by scientifically matching seven active functional components and combining the three-phase layered targeting delivery system, improves the utilization rate of components, can be produced on a large scale, and improves the storage stability of the composition.
Owner:ENWEIDA (HAINAN) CONSULTING SERVICES CO LTD

Preparation method of highland barley protein peptide with hypoglycemic activity

The invention discloses a preparation method of highland barley protein peptide with hypoglycemic activity, and belongs to the field of biotechnology and functional food. According to the preparation method, highland barley protein is extracted from highland barley powder by adopting an alkali-solution and acid-isolation method, then the highland barley protein peptide is prepared by sequentially adopting alkaline protease and bromelain to carry out step-by-step enzymolysis, and the complementary and synergistic effects of different restriction enzyme cutting sites are realized through a step-by-step enzymolysis strategy of'alkaline protease-bromelain 'in a specific sequence. Aromatic and hydrophobic amino acids are preferentially cut by the alkaline protease, the space structure of the protein is opened, and more effective sites are provided for bromelain, so that small molecular peptide fragments with hypoglycemic activity are more efficiently released, and in-vitro experiments show that the inhibition rate of the bromelain on alpha-amylase is up to 52.49%, and the inhibition rate of the bromelain on the bromelain is up to 52.49%. The inhibition rate of alpha-glucosidase reaches up to 73.35%, which is far better than that of a single enzymolysis product.
Owner:JIANGNAN UNIV +1

A quercetin-eucalyptus-oil composition for clearing and protecting the lungs

PCT designated stageWO2026115530A3BiotechnologyPerillaldehyde
The present invention discloses a quercetin-eucalyptus-oil composition for clearing and protecting the lungs, relating to the technical field of functional foods. The composition comprises active functional components and a three-phase layered targeted-delivery system. The active functional components comprise, in parts by weight, 5-20 parts quercetin, 1-8 parts eucalyptus oil, 2-10 parts bromelain, 10-30 parts dihydromyricetin, 1-6 parts perillaldehyde, 3-15 parts icariin, and 1-5 parts ultra-low-molecular-weight sodium hyaluronate. The three-phase layered targeted-delivery system comprises three independent encapsulation units, namely enteric-protective microspheres encapsulating bromelain, nano mixed micelles encapsulating quercetin, dihydromyricetin, and icariin, and sustained-release microcapsules encapsulating eucalyptus oil and perillaldehyde. By scientifically combining the seven active functional components with the three-phase layered targeted-delivery system and by improving the preparation process, the present invention solves the problems of component incompatibility and easy inactivation in conventional compositions, improves ingredient utilization, enables large-scale production, and enhances the storage stability of the composition.
Owner:ZIRAOUI NOUR-EDDINE

Medicine for skin regeneration and repair and preparation method thereof

The present application relates to a kind of skin regeneration repair medicine and preparation method thereof, belong to biological medicine technical field, and medicine includes oil palm extraction peptide, tiger palm silver ear extract, Gangdeng root-milletia nitida-Siberian milkvetch composite extract and pomegranate peel polyphenol etc.Oil palm extraction peptide is oil palm sequentially by cellulase, alpha-chymotrypsin and ficin enzymolysis, then by G-50 dextran gel column purification and obtain the product above 1kDa;Tiger palm silver ear extract is tiger palm silver ear fruit body by cellulase and bromelain common enzymolysis, and obtain the product below 3kDa;Gangdeng root-milletia nitida-Siberian milkvetch composite extract is Gangdeng root, milletia nitida and siberian milkvetch by gradient extraction of ethanol aqueous solution and obtain extract, sequentially by polyamide resin column adsorption and LH-60 dextran gel column purification and obtain the product.Multiple components construct good repair system, accelerate wound repair healing.
Owner:HUBEI SHUANGXING PHARMA CO LTD

Composite bromelain and application thereof in medicine for improving dyspepsia

PendingCN120714012APeptide/protein ingredientsDigestive systemDigestionIndigestion symptoms
The invention belongs to the technical field of protease, and particularly relates to composite bromelain and application thereof in a medicine for improving dyspepsia. The invention discloses compound bromelain. The compound bromelain is prepared by mixing bromelain, rhamnosidase and lipase according to the mass ratio of (1: 3)-(7: 1). The compound bromelain disclosed by the invention has a synergistic effect and can effectively enhance gastrointestinal motility, accelerate transmission and emptying of food in gastrointestinal tracts and improve dyspepsia symptoms caused by insufficient gastrointestinal motility, such as abdominal distension, early satiety and the like. Besides, the compound bromelain disclosed by the invention not only can maintain the self enzymatic activity, but also can synergistically promote the activity of other digestive enzymes and enhance the capability of decomposing various components in food, so that macromolecules in the food can be more effectively decomposed into micromolecular nutrient substances, the digestion efficiency is improved, and the digestion effect is improved. The dyspepsia caused by insufficient secretion or low activity of digestive enzymes is solved.
Owner:NANNING DONG HIGHER BIO TECH