96 results about "Melibionic acid" patented technology

The invention discloses vesicles consisting of amphiphilic polymer and application of the vesicles. A main chain of the amphiphilic polymer consists of a hydrophilic chain segment and a biodegradable hydrophobic chain segment, wherein the molecular weight of the hydrophilic chain segment is 4 to 6kDa; the molecular weight of the hydrophobic chain segment is 3 to 5 times that of the hydrophilic chain segment; the hydrophobic chain segment is formed by performing random copolymerization on a monomer A and a monomer B in a molar ratio of (5-20):1; the monomer A is trimethylene carbonate or cyclic carbonate; the monomer B is acrylate-based carbonate or vinyl sulfone-based carbonate; the hydrophobic chain segment is grafted with a short branched chain; the grafting position is a double bond of the monomer B; a monomer forming the short branched chain is 3-mercaptopropionic acid, cysteamine hydrochloride or cysteine; and the grafting rate is 0.3 to 1. The vesicles are directly prepared from the amphiphilic polymer in an aqueous solution and used as a carrier and a release system of a protein medicine, the encapsulating efficiency and bioavailability of the protein medicine can be improved, and the stability of the encapsulated protein is enhanced.

The invention relates to a method for preparing a silane polycarboxylate water-reducing agent, relates to a water-reducing agent in a concrete admixture and belongs to the technical field of building materials. The silane polycarboxylate water-reducing agent is prepared from polyoxyethylene ether macromonomer, sodium acrylate or a derivative monomer thereof, chain transfer agents, initiators, a silane functional monomer, 2-acryloyl amino-2-methyl-1-propane sulfonic acid and deionized water. The chain transfer agents are thioglycolic acid, mercaptopropionic acid, sodium methallyl sulfonate and sodium allylsulfonate. The initiators are sodium persulfate and ammonium persulfate. Silane monomer maleic anhydride and triethoxy silane propylamine are prepared through amidation. The silane polycarboxylate water-reducing agent is novel in molecular structure design, high in sulfate resistance and good in concrete material adaptability. The product has an obvious sulfate resistance effect while having a high performance water-reducing effect.

The invention discloses a polycarboxylate water reducer with a defoaming function and a preparation method of the water reducer. The water reducer is prepared from the following raw materials: polyoxyethylene ether macromonomers, acrylic acid or derivative monomers of acrylic acid, a chain transfer agent, an initiator, defoaming monomers and de-ionized water, wherein the chain transfer agent is selected from thioglycollic acid, thiohydracrylic acid, sodium methallylsulphonate and sodium allysulfonate; the initiator is selected from hydrogen peroxide, ascorbic acid, sodium persulfate and ammonium persulfate; the defoaming monomers are polyoxyethylene-polyoxypropylene block copolymers. The preparation method comprises the following steps of pouring the polyoxyethylene ether macromonomers and the de-ionized water into a three-mouth flask, and adding the chain transfer agent; dissolving the initiator in the de-ionized water to prepare a solution A; dissolving acrylic acid or the derivative monomers of acrylic acid and the defoaming monomers in the de-ionized water to prepare a solution B; dropwise adding the solution A and the solution B by adopting a constant flow pump at the same time, performing insulation reaction, naturally cooling, and adjusting the pH value to obtain the water reducer. The water reducer has a defoaming function while having a high-performance water reducing effect.

The invention belongs to the field of pharmacy, and especially relates to a preparation method for green and environmentally friendly sugammadex sodium. The preparation method obtains a crude productof sugammadex sodium through preparation for the first time by taking 3-mercaptopropionic acid, alkali and 6-deoxy-6-perhalogeno-gamma-cyclodextrin as raw materials; and high purity sugammadex sodiumcan be obtained after desolvation through recrystallization and column chromatography purification. Compared with the prior art, a reaction solvent of the preparation method can replace organic solvents like N,N-dimethylformamide used by traditional methods by only using water, so that disadvantages of hard recovery and large pollution caused by large amount of high boiling organic solvents can beimproved; and the sugammadex sodium is clean and environmentally friendly, green and efficient, has advantages of being mild in reaction condition, high in product purity, simple in post-treatment step, high in product yield, low in cost and convenient for industrialization, and has good application prospects.

The invention discloses a method for preparing a polycarboxylic acid water reducing agent by using sodium methyl acryl sulfonate as a chain transfer agent. The method comprises the following steps of: firstly, adding water, sodium methyl acryl sulfonate and modified polyether in a reaction kettle; then mixing sodium methyl acryl sulfonate and acrylic acid with water to prepare an acrylic acid solution, mixing water with ammonium persulfate to prepare an ammonium persulfate solution; when the temperature of materials reaches 60 DGE C+ / -2 DEG C, simultaneously dropwise adding the ammonium persulfate solution and the acrylic acid solution; and carrying out heat insulation reaction for 1-3 hours and when cooling below 45 DEG C, adding 32% liquid caustic soda for neutralization so as to obtain the polycarboxylic acid water reducing agent having the PH value of 6-7 and 40% of solid content. Because sodium methyl acryl sulfonate is used as the chain transfer agent instead of mercaptoacetic acid or mercaptopropionic acid in the preparation process of the polycarboxylic acid water reducing agent, environment pollution and toxic action on a human body caused by stink odor and strong corrosivity of mercaptoacetic acid or mercaptopropionic acid can be avoided.

The invention relates to a process for the catalytic synthesis of bisphenol fluorene by using concentrated sulphuric acid. Concentrated sulphuric acid is taken as catalyst, beta-mercapto propionic acid is taken as cocatalyst, phenol is taken as reactant and solvent, reaction with fluorenone is fully carried out under mild condition, one organic polar solvent and water are added, so as to cause unreacted phenol and product are layered with concentrated sulphuric acid; water phase is removed, the obtained organic phase is washed by alkaline solution and softened water step by step, condition is controlled and reduced pressure distillation is carried out to obtain the organic polar solvent and phenol respectively, temperature reduction is carried out, then recrystallization solvent is added for recrystallization, thus obtaining bisphenol fluorine white solid the purity of which is more than 99.0%. The process has low reaction temperature, short time, high productivity more than 90% and high purity more than 99.0%; besides, the used catalyst concentrated sulphuric acid and cocatalyst beta-mercapto propionic acid are low in cost, concentrated sulphuric acid consumption is low, phenol is easy to recycled, recovery rate reaches 80%, and environmental pollution is less, thus the method is applicable to industrialized production.

The present invention provides a process for the preparation of sugammadex sodium involving the step of: reacting 6-perdeoxy-6-per-halo-gamma-cyclodextrin with 3-mercapto propionic acid in the presence of alkali metal alkoxide in an organic solvents. The invention also provides a process for purifying the sugammadex or its pharmaceutically acceptable salts using water and organic solvents.

The invention discloses a preparation method of a high-performance solid polycarboxylic acid water reducer. The preparation method comprises the following steps of: preparing materials: firstly, pumping acrylic acid and thiohydracrylic acid into a first metering tank through a pump as a material A for later use, and then pumping a vitamin C aqueous solution into a second metering tank as a material B for later use; adding water and methyl allyl polyethenoxy ether into a reaction kettle. And heating the mixture till the methyl allyl polyethenoxy ether is dissolved; a polymerization reaction: adding an active protecting agent, a viscosity modifier and an ammonium persulfate aqueous solution into the reaction kettle, and dropwise adding the materials A and B at the same time, and after dropwise addition, keeping the temperature and performing the polymerization reaction on the materials to obtain a liquid polycarboxylic acid water reducer; cooling and slicing: cooling and slicing the liquid polycarboxylic acid water reducer in a slicer; crushing: cooling and slicing the sliced polycarboxylic acid water reducer; and automatically packaging the crushed solid polycarboxylic acid water reducer in a packaging machine. By means of body polymerization-low-temperature slicing and crushing, reduction of performance due to damage of organic structures of active ingredients by high-temperature drying is effectively reduced; in the production process, the water consumption is small and the energy consumption is low.

The invention provides a method for fixing a protein on the surface of polydimethylsiloxane. The method is characterized in that a biotinylated polydimethylsiloxane film is prepared on the solidified surface of polydimethylsiloxane, a protein is fixed on the surface of polydimethylsiloxane by chemical technologies of biotin-avidin and water-soluble carbodiimide and a technology of 3-mercaptopropionic acid stabilized gold nano-particles, and beta-D-dodecyl-N-maltose and bovine serum albumin are utilized respectively for blockading the non-specific adsorption of a protein on the surface of polydimethylsiloxane and activated residual carboxylic groups on the surface of a 3-mercaptopropionic acid stabilized gold nano-particle. In the invention, the surface of a 3-mercaptopropionic acid stabilized gold nano-particle contains multiple carboxylic groups which can combine molecules of multiple proteins needing to be fixed thus multiple proteins needing to be fixed can be fixed on the surface of polydimethylsiloxane and a sensitivity of a subsequent enzyme-linked immuno sorbent assay (ELISA) is improved effectively.

The embodiment of the invention relates to the field of synthesis of sulfhydryl compounds, in particular to a preparation method of 3-mercaptopropionic acid. The preparation method includes the stepsthat sodium acrylate and sodium bisulfide or sodium sulfide are mixed and have a reaction; the sodium sulfide is added (or the sodium sulfide and powdered sulfur are added), and the reaction is continued; crystallization and acidification by adding acid are conducted, and a 3-mercaptopropionic acid solution is obtained. According to the preparation method, the costs of raw materials are low, the yield of the 3-mercaptopropionic is high, the purity of the 3-mercaptopropionic is high, solid waste and a solvent can be separated and recycled, a sodium salt is used as an industrial product after crystallization, the solvent is distilled, recycled and reused, and three wastes are easy to process.

The invention discloses a sorbitol acrylate citric acid modified polycarboxylic acid water reducing agent. The water reducing agent is a copolymer formed by polymerizing sorbitol acrylate citric acid,acrylic acid, an unsaturated polyether macromonomer, an initiator and a chain transfer agent through a free radical copolymerization reaction; the unsaturated polyether macromonomer is one or two ofallyl polyoxyethylene ether, methylallyl alcohol polyoxyethylene ether and isoamylene polyoxyethylene ether; the initiator is at least one of hydrogen peroxide, ammonium persulfate and potassium persulfate, or any one of hydrogen peroxide, ammonium persulfate and potassium persulfate in combination with at least one of ascorbic acid, sodium formaldehyde sulfoxylate and ferrous sulfate; the chain transfer agent is at least one of mercaptopropionic acid, thioglycolic acid, mercaptoethanol, mercaptoethylamine, sodium methallyl sulfonate, sodium hypophosphite and sodium allylsulfonate. According to the sorbitol acrylate citric acid modified polycarboxylic acid water reducing agent, a hydration film can be generated on the surface of cement particles, and the slump retaining capability of the water reducing agent and the adaptability to the mechanical sand of different flooring materials and the retarding effect on the concrete can be further improved.

The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6- per-halo-[gamma]-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.

A process for preparing sugammadex sodium comprising:reacting a γ-cyclodextrin of formula I with a halogenating agent in the presence of N-methyl-2-pyrrolidone to provide a compound of formula II; andreacting the compound of formula II with 3-mercapto propionic acid in the presence of a sodium base and an organic solvent to provide sugammadex sodium formula III:wherein X in formula II is halo.

The invention belongs to the field of macromoleclar polymerization and relates to a method for preparing a branched polymer by using a vinyl benzene monomer containing polymerizable double bonds and chain transfer sulfydryl. In the method, vinyl benzyl sulfydryl propionate serving as a functional monomer and a vinyl monomer such as vinyl benzene undergo polymerization at 60 to 135 DEG C in methylbenzene, benzene or dimethylbenzene serving as a solvent in the presence of azodiisobutyronitrile (AIBN) serving as an initiator to form the branched polymer successfully. The branch degree of the branched polymer can be regulated by regulating the molar ratio of the branched monomer and the polymer monomer, polymerization temperature and polymerization time. In the method, the vinyl benzyl sulfydryl propionate with high storage stability is used as the branched monomer to form the branched polymer under a conventional free radical polymerization condition successfully, the polymerization conditions are mild, the operation is simple and easy to implement, the monomer conversion rate is high, and the degree of branching of the polymer is controllable; and the method has high adaptability for synthesizing branched polymers by using various monomers.