106 results about "3-Mercaptopropionic Acid" patented technology

The invention discloses vesicles consisting of amphiphilic polymer and application of the vesicles. A main chain of the amphiphilic polymer consists of a hydrophilic chain segment and a biodegradable hydrophobic chain segment, wherein the molecular weight of the hydrophilic chain segment is 4 to 6kDa; the molecular weight of the hydrophobic chain segment is 3 to 5 times that of the hydrophilic chain segment; the hydrophobic chain segment is formed by performing random copolymerization on a monomer A and a monomer B in a molar ratio of (5-20):1; the monomer A is trimethylene carbonate or cyclic carbonate; the monomer B is acrylate-based carbonate or vinyl sulfone-based carbonate; the hydrophobic chain segment is grafted with a short branched chain; the grafting position is a double bond of the monomer B; a monomer forming the short branched chain is 3-mercaptopropionic acid, cysteamine hydrochloride or cysteine; and the grafting rate is 0.3 to 1. The vesicles are directly prepared from the amphiphilic polymer in an aqueous solution and used as a carrier and a release system of a protein medicine, the encapsulating efficiency and bioavailability of the protein medicine can be improved, and the stability of the encapsulated protein is enhanced.

The invention discloses fluorescent wide chroma test paper for visually detecting copper ions as well as a preparation method and application of the test paper. The preparation method comprises the following steps: by taking a three-color ratio fluorescence probe as ink and taking filter paper as a solid-phase carrier through an inkjet printer, uniformly printing, thereby obtaining the test paper capable of visually detecting the copper ions, wherein the three-color ratio fluorescence probe refers to blue carbon dots, green quantum dots and red quantum dots, and the quantum dots are all modified by 3-mercaptopropionic acid. The three-color ratio fluorescence test paper is constructed to be used for visually detecting the copper ions by utilizing double-quenching principle first, the prepared detection test paper has the advantage that the color change range is wide compared with the conventional double-ratio fluorescence test paper, and along with addition of the detection object, test paper colors can be obviously identified by naked eyes from light scarlet, light flesh color, deep orange, grass green, dark olive green, slate blue, royalblue to cyanic color (Figure 4).

The invention relates to a preparation method of 3-mercaptopropionic acid. Sodium hydroxide solution, sodium hydrosulfide and sodium polysulfide (as catalyst) are mixed, then acrylonitrile is dripped into the mixture at the temperature of 20-70 DEG C to produce under insulated temperature the mixed solution of a plurality of intermediates, then hydrochloric acid is added for acidification and iron powder is added for deoxidization, thus acquiring the solution of 3-mercaptopropionic acid. The raw material sodium hydrosulfide selected in the reaction is cheap, reducing the production cost; hydrogen sulfide gas that is produced after the hydrochloric acid is added can be recycled to produce hydrogen sulfide nano, the production cost is further reduced; the final waste liquid mainly contains surplus hydrochloric acid and ammonia chloride, which is easy to be disposed; pollution is hardly caused during the whole reaction process.

The present invention provides a process for the preparation of (6-per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin) sodium salt, comprising the steps of:reacting γ-cyclodextrin (SM1) with iodine in the presence of triphenylphosphine in an organic solvent to afford an intermediate, 6-per-deoxy-6-iodo-γ-cyclodextrin (abbreviated as SGMD-1);adding methanol solution of sodium methoxide into the reaction system followed by the addition of acetone without removal of the solvent under reduced pressure to obtain the crude SGMD-1 as a solid after filtration;purifying the crude SGMD-1 by recrystallization;reacting a obtained recrystallized intermediate (SGMD-1) with 3-mercaptopropionic acid in basic medium e.g., sodium hydride, to obtain the crude 6-per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt (abbreviated as SGMD);purifying the crude SGMD by passing through adsorbents followed by recrystallization.

The invention discloses the production method and use for imidacloprid artificial hapten, artificial antigen and specific antibody, wherein the production method comprises, using imidacloprid (1-(6-chlorine-3-picolyl)-N-nitro-2-imidazoline imine) as raw material for reaction with 3-mercaptopropionic acid under alkaline condition, thus synthesizing hapten 1-(6-(2-carboxyethyl) sulfo-3-picolyl)-N-nitro-2-imidazoline imines (IM), then coupling with proteins through carbodiimide method and mixed anhydride method to prepare artificial antigens (immunogens and peridium antigens).

The present invention provides aqueous amphiphilic emulsion copolymer compositions comprising one or more aqueous phase copolymer, a residue of one or more hydrophilic chain transfer agent, and a residue of one or more hydrophobic chain transfer agent, as well as methods of making such copolymers in water or an aqueous liquid by copolymerizing a monomer component of from 20 to 80 wt. %, based on the weight of the monomer component, of a hydrophilic group-containing monomer and the remainder of a copolymerizable ethylenically unsaturated monomer or prepolymer in the presence of a mixed chain transfer agent component comprising a hydrophilic chain transfer agent, such as 3-mercaptopropionic acid, and a hydrophobic chain transfer agent, such as N-dodecyl mercaptan. The aqueous amphiphilic emulsion copolymers of the present invention are storage stable and exhibit excellent viscosity control even in high solids compositions, e.g. from 50 to 80 wt. % of the composition. The high solids compositions can be diluted at the point of use, thus reducing shipment costs.

The invention belongs to the field of pharmacy, and especially relates to a preparation method for green and environmentally friendly sugammadex sodium. The preparation method obtains a crude productof sugammadex sodium through preparation for the first time by taking 3-mercaptopropionic acid, alkali and 6-deoxy-6-perhalogeno-gamma-cyclodextrin as raw materials; and high purity sugammadex sodiumcan be obtained after desolvation through recrystallization and column chromatography purification. Compared with the prior art, a reaction solvent of the preparation method can replace organic solvents like N,N-dimethylformamide used by traditional methods by only using water, so that disadvantages of hard recovery and large pollution caused by large amount of high boiling organic solvents can beimproved; and the sugammadex sodium is clean and environmentally friendly, green and efficient, has advantages of being mild in reaction condition, high in product purity, simple in post-treatment step, high in product yield, low in cost and convenient for industrialization, and has good application prospects.

The invention discloses a method for preparing 3-mercaptopropionic acid, comprising the following steps of: (1), after mixing thiourea and hydrochloric acid, stirring; (2), dropping acrylic acid; keeping temperature at 80-90 degrees centigrade; and keeping the reaction for 1-7 h; (3), adding sodium hydroxide solution; hydrolyzing; generating sulphur sodium propionate and urea; and (4), acidizing by adding hydrochloric acid; preparing solution containing 3-mercaptopropionic acid; and, after extracting through an organic solvent, decompressing and distilling to obtain the 3-mercaptopropionic acid. Reaction liquid contains a few by-products. The extraction process is easily carried out. The product is good in colour and high in content. After being extracted, waste liquid can be separated and recycled by simply distilling and filtering. Residual liquid can be added to new waste liquid to be further treated. The zero emission of the three wastes (waste gas, waste water and industrial residue) can be basically realized.

A composition for permanent hair shaping comprising: (i) about 0.5% by weight to about 30% by weight of a N-alkyl-2-mercaptoacetamide of formula or the salt thereof, wherein R1 is a straight chain alkyl residue with about 3 to about 6 carbon atoms or a straight chain hydroxyalkyl with about 3 to about 6 carbon atoms, R2 and R3 are, independently from each other, hydrogen or straight chain alkyl residues with about 1 to about 3 carbon atoms; (ii) about 0.1% by weight to about 20% by weight of at least one further hair keratin reducing agent selected from the group consisting of thioglycolic acid, thiolactic acid, 3-mercaptopropionic acid, 2-hydroxy-3-mercaptopropionic acid, cysteine, cysteamine, alkyl- or acylcysteamine with about 1 to about 4 carbon atoms in the alkyl residue, or the salt thereof; cysteine-(2-hydroxyethyl)ester, L-cysteine glycerine ester, and glycerine mono thioglycolate; and (iii) about 5% by weight to about 95% by weight of water and a method of permanently shaping hair using said composition.

The invention provides an LSPR (Localized Surface Plasmon Resonance) sensing chip for detecting plasmid DNA (deoxyribonucleic acid) containing an oncogene C-myc antigen fragment on the basis of LSPR. The LSPR sensing chip is characterized in that one DTT (Dithiothreitol) unimolecule layer (2) is assembled on the surface of a gold film (1) of the LSPR sensing chip; a gold nanoparticle layer (3) is accessed; the surface of the gold nanoparticle layer (3) is furnished with a 3-mercaptopropionic acid unimolecule layer (4); then DMAP-EDC [4-Dimethylamino pyridine-1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide] activation ensures that the 3-mercaptopropionic acid unimolecule layer (4) is combined with a C-myc monoclonal antibody (5); and the immune response combination of the C-myc monoclonal antibody (5) and the plasmid DNA (6) containing the C-myc antigen fragment causes that the surface of the gold nanoparticle generates the displacement of a local surface plasma resonance absorption peak so as to detect the content of the plasmid DNA (6) containing the C-myc antigen fragment in canceration tissues. The invention has the beneficial effects that the LSPR sensing chip has the advantages of multiple-path detection, high sensitivity and good selectivity and repeatability, is simple and convenient to assemble and is quick to quantify. The LSPR sensing chip is superior to the LSPR sensing chip manufactured with the traditional chromatin immunoprecipitation (ChIP) method.

The invention relates to a nucleation water-phase preparation method of ZnSe:Mn quantum dots, belonging to the technical field of composite nano microcrystal materials. The inner core of the product is MnSe quantum dots, and the outer layer is ZnSe quantum dots. The preparation method comprises the following steps: reacting sodium borohydride (NaBH4) and selenium powder to prepare sodium hydrogen selenide (NaHSe), injecting the sodium hydrogen selenide into a manganese acetate / 3-mercaptopropionic acid solution of which the pH value is regulated by sodium hydroxide so as to react to generate a MnSe quantum dot solution, and adding a zinc acetate / 3-mercaptopropionic acid solution of which the pH value is regulated by sodium hydroxide into the MnSe quantum dot solution to form ZnSe:Mn quantum dots. The product obtained by the method provided by the invention has the advantages of uniform dispersion, high stability and less aggregation, and can be used in the fields of biological fluorescence labeling, drug isolation and some photoelectric devices.

The invention discloses an electrochemical immunosensing method for detecting Listeria monocytogenes, belonging to the field of the biotechnological detection. The surface of a gold electrode is activated electrochemically and then is immersed in 1% of 3-mercaptopropionic acid ethanol solution to be self-assembled to form a monomolecular film, a capture antibody is combined to the surface of the electrode after activation, an enzyme amplification signal is introduced by a sandwich method, and an enzymatic electroactive substance is subjected to oxidation reduction to obtain a current response signal, therefore, a method for detecting the Listeria monocytogenes by use of the electrochemical immunosensor adopting three electrodes as a system is established; the method has good sensitivity, specificity and stability; the detection system is small, the reagent is saved, the detection cost is reduced remarkably, the method has great potential in application and practical sample detection due to no influence from the turbidity of the sample.

The present invention relates to a method for producing 3-mercaptopropionic acid and carbonic acid ester composition having mercapto group using same, and a method for producing thiourethane-based optical materials. The method for producing 3-mercaptopropionic acid according to the present invention does not include a post-processing treatment, which is necessitated by generation of a dimer such as thiodipropionitrile, thereby the process is simple and economical, and exhibits superior yield rate. Additionally, the carbonic acid ester composition produced with 3-mercaptopropionic acid produced using the method exhibit superior purity and coloring, and allows production at a low cost, and thus has the benefit of being usable as an inexpensive resin composition for urethane-based optical materials, and ptical materials thus produced exhibit excellent coloring. Thiourethane-based optical lenses having good coloring, obtained by means of the present invention, can replace existing lenses and be widely used in diverse fields.

The invention belongs to the technical field of nano magnetic materials and biology and in particular relates to composite magnetic nanoparticles Fe3O4@Au / MPA / NTA-Ni<2+> as well as preparation and application thereof. BSA (Bull Serum Albumin) surface sulfhydrylation magnetic Fe3O4 nanoparticles and gold nanoparticles are self-assembled under the action of a disulfide bond to form superparamagneticFe3O4@Au nanoparticles; after surfaces of the superparamagnetic Fe3O4@Au nanoparticles are carboxylated by adopting MPA (3-mercaptopropionic acid), coupling with an affinity ligand NTA-Ni<2+> throughan amide bond effect; the prepared Fe3O4@Au / MPA / NTA-Ni<2+> composite magnetic nanoparticles have superparamagnetic performance, the average hydration particle diameter is 100nm to 1000nm, the averageZeta potential is 0 to -25mv and the dispersity is good; when the composite magnetic nanoparticles are applied to protein separation and purification, a process is simple and the separation is rapid;after being circularly used for 6 times, the composite magnetic nanoparticles still have relatively high separation and purification efficiency.

The invention belongs to the technical field of preparation of environmental materials, and relates to a preparation method and uses of a MoS2 / BiVO4 composite photocatalyst synthesized by a hydrothermal method. The preparation method comprises: preparing MoS2 nano-sheets; adding bismuth nitrate and polyvinylpyrrolidone into ethylene glycol, and ultrasonically dispersing and dissolving to obtain amixed solution A; adding NH4VO3 into deionized water, and ultrasonically dispersing and dissolving to obtain a mixed solution B; slowly adding the MoS2 nano-sheets, 3-mercaptopropionic acid and the mixed solution B into the mixed solution A under magnetic stirring, transferring the mixed solution into a high-pressure kettle, and carrying out a constant-temperature reaction; and centrifuging aftercompleting the reaction, washing the obtained precipitate, and drying to obtain a MoS2 / BiVO4 composite photocatalyst. According to the present invention, the method has characteristics of simple and convenient operation, safety and environmental protection; and the morphology of the catalyst shows the characteristics of 0D BiVO4 / 2DMoS2, the active specific surface area of the catalyst is large, and the catalyst is used for degrading harmful substances in environmental wastewater.

The invention provides a preparation method of a metal quantum dot plasma coupler color filter. The preparation method comprises the steps that 1) metal nanoparticles (1) are prepared by utilizing a polyol method; 2) metal / SiO2 core / shell composite particles (3) coated by silicon dioxide shell layers (2) of different thicknesses are prepared; 3) amination of the surface of the metal / SiO2 core / shell composite particles is performed by utilizing 3-aminopropyltriethoxysilane; 4) oil phase red light quantum dots and green light quantum dots (4) are prepared by utilizing a high temperature thermal decomposition method and surface ligands are replaced by 3-mercaptopropionic acid; 5) the metal / SiO2 core / shell composite particles are connected with the quantum dots by utilizing a self-assembling method so that a metal quantum dot plasma coupler (5) is formed; 6) ethyl orthosilicate is catalyzed to be hydrolyzed by utilizing ammonia to prepare SiO2 sol; 7) the metal quantum dot plasma coupler is mixed with the SiO2 sol so that metal quantum dot plasma coupler dispersion liquid is formed; and 8) metal quantum dot plasma coupler dispersion liquid is enabled to form a pixel image by utilizing a spraying method.

The invention provides a method for rapidly preparing a thick-wall CdTe / CdS quantum dot with the controllable shell thickness, belonging to the field of nanometer material synthesis. The method is characterized in that a CdTe quantum dot is used as a raw material, 3-mercaptopropionic acid is used as a stabilizing agent and a sulphur source, water is used as a solvent, cadmium salt and the 3-mercaptopropionic acid are prepared into a solution at according to certain proportions, and the CdTe / CdS core-shell type quantum dot with different CdS shell thicknesses can be obtained by controlling reaction conditions through a microwave heating reaction. The method has advantages that the reaction conditions are mild, the operation is simple and convenient, the reaction time is short, the CdS shell with the controllable thickness can grow, the light-emitting wavelength range of the prepared core-shell quantum dot is continuous and adjustable, and the core-shell quantum dot has strong light stability.

The invention provides a method for fixing a protein on the surface of polydimethylsiloxane. The method is characterized in that a biotinylated polydimethylsiloxane film is prepared on the solidified surface of polydimethylsiloxane, a protein is fixed on the surface of polydimethylsiloxane by chemical technologies of biotin-avidin and water-soluble carbodiimide and a technology of 3-mercaptopropionic acid stabilized gold nano-particles, and beta-D-dodecyl-N-maltose and bovine serum albumin are utilized respectively for blockading the non-specific adsorption of a protein on the surface of polydimethylsiloxane and activated residual carboxylic groups on the surface of a 3-mercaptopropionic acid stabilized gold nano-particle. In the invention, the surface of a 3-mercaptopropionic acid stabilized gold nano-particle contains multiple carboxylic groups which can combine molecules of multiple proteins needing to be fixed thus multiple proteins needing to be fixed can be fixed on the surface of polydimethylsiloxane and a sensitivity of a subsequent enzyme-linked immuno sorbent assay (ELISA) is improved effectively.

The invention discloses a preparation method and application of a parathion-methyl artificial hapten, a parathion-methyl artificial antigen and a parathion-methyl specific antibody, and belongs to the technical field of pesticide immunologic chemistry. The method comprises the following steps of: introducing spacer arms and active groups into a methoxyl site of parathion-methyl by taking 3-mercaptopropionic acid as a functional group reagent to synthesize O-methyl-N-(2-carboxyethyl) sulfo-O-(4-nitrobenzophenone) phosphorothioate (MP for short) serving as the hapten; and coupling the hapten with protein in a mixed anhydride method and an active ester method to prepare the artificial antigen. In the method, the parathion-methyl antibody with high affinity and high specificity is prepared by immunizing an animal through an immunogen, and enzyme-linked immunosorbent assay (ELISA) established by the antibody can be used for detecting trace quantity of parathion-methyl residues in a sample quickly.

The invention discloses a polyurethane photochromic lens and a preparation method thereof. The lens comprises the raw materials: polyester diol, isophorone diisocyanate, 2,2-dimethylol propionic acid,methyl methacrylate, styrene, an initiator, glycerol, 3-mercaptopropionic acid, methylbenzene, p-toluenesulfonic acid, a photochromic material and a UV adsorbent. The preparation method comprises thesteps: firstly, mixing glycerol, 3-mercaptopropionic acid, methylbenzene and p-toluenesulfonic acid to carry out a reaction to prepare a curing agent; then, adding polyester diol, isophorone diisocyanate and 2,2-dimethylol propionic acid into a mixed solution of methyl methacrylate and styrene, carrying out mixing, then, adding the curing agent, the photochromic material and the UV adsorbent, andcarrying out stirring to prepare mixed slurry; and pouring the mixed slurry into a die, and placing the die into an air curing furnace to carry out primary curing and secondary curing to obtain the polyurethane photochromic lens. The prepared lens has excellent photochromic and mechanical properties and can be widely applied.

The invention relates to a water-phase preparation method of ZnSe:Ag quantum dots, belonging to the technical field of composite nano microcrystal materials. The preparation method comprises the following steps: reacting sodium borohydride (NaBH4) and selenium powder to prepare sodium hydrogen selenide (NaHSe), and injecting the sodium hydrogen selenide into a zinc nitrate / 3-mercaptopropionic acid solution of which the pH value is regulated by sodium hydroxide so as to react, thereby obtaining a light-brown transparent ZnSe:Ag quantum dot solution. The product obtained by the method provided by the invention has the advantages of uniform dispersion, high stability and less aggregation, and can be used in the fields of biological fluorescence labeling, drug isolation and some photoelectric devices.

The invention discloses a near-infrared copper-indium-selenium quantum dot and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving cupric chloride or copper acetate, indium acetate, sodium hydrogen selenide and 3-mercaptopropionic acid according to the molar ratio of 1:2.5-5:4-8:24-26, so as to obtain a mixed solution, wherein the concentration of cupric chloride or copper acetate is 0.7-0.9 mmol / L; and (2) adjusting the pH value of the mixed solution obtained in the step (1) to 8-9, then heating the mixed solution at 93-98 DEG C for reaction for 60-90 min, and cooling to room temperature, so as to obtain the near-infrared copper-indium-selenium quantum dot. The prepared quantum dot has the advantages of being nontoxic, simple in method, mild and controllable in reaction conditions, short in reaction time, good in reappearance and the like. The prepared quantum dot is widely applicable to cell and tissue imaging as a fluorescent marker, and also is applicable to in vivo imaging research.

The invention discloses a preparation method of surface-carboxylation gold magnetic core shell nano-composite particles, and belongs to the field of biomedical engineering. According to the preparation method, magnetic Fe<3>O<4> nano particles are prepared by means of a solvothermal method at first, surface modification is conducted on the magnetic Fe<3>O<4> nano particles by means of tetraethyl orthosilicate and silane coupling agent with carboxyl modified, the magnetic Fe<3>O<4> nano particles subjected to surface modification are subjected to surface sulfhydrylization with bovine serum albumin (BSA), then gold nano particles prepared with a sodium citrate reduction method are added, Fe<3>O<4> @ Au core shell nano-composite particles are obtained through formation and assembly of disulfide bonds, finally the nano-composite particles are subjected to surface carboxylation by means of 3-mercaptopropionic acid (MPA), and the surface-carboxylation gold magnetic core shell nano-compositeparticles are obtained. The surface-carboxylation gold magnetic core shell nano-composite particles are good in dispersity, high in stability and high in magnetic performance, the average hydration particle size is 860.2 nm, the distribution coefficient PDI is 0.103, the average Zeta potential is -30.1 mv, meanwhile the result of infrared spectroscopy indicates that the surfaces of the nano-composite particles contain carboxyl groups which can be further functionalized, and the application potential of the nano-composite particles in the biomedical field of targeted drug controlled release, thermal therapy, cell and protein separation and the like is expanded.

The present invention provides a process for the preparation of (6-per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin) sodium salt, comprising the steps of:reacting γ-cyclodextrin (SM1) with iodine in the presence of triphenylphosphine in an organic solvent to afford an intermediate, 6-per-deoxy-6-iodo-γ-cyclodextrin (abbreviated as SGMD-1);adding methanol solution of sodium methoxide into the reaction system followed by the addition of acetone without removal of the solvent under reduced pressure to obtain the crude SGMD-1 as a solid after filtration;purifying the crude SGMD-1 by recrystallization;reacting a obtained recrystallized intermediate (SGMD-1) with 3-mercaptopropionic acid in basic medium e.g., sodium hydride, to obtain the crude 6-per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt (abbreviated as SGMD);purifying the crude SGMD by passing through adsorbents followed by recrystallization.

A method for preparing 3-mercapto-propionate is as below: subjecting a main raw material of 3-mercaptopropionic acid and an alcohol compound to a heating esterification reaction in the presence of an acidic catalyst to prepare a 3-mercaptopropionic acid ester compound crude product; and then extracting and purifying the target product by using the differences in solubility of 3-mercaptopropionate and 3-mercaptopropionic acid residue and catalyst to choose the appropriate solvent. Compared with the prior art, the invention has the beneficial effects that the preparation process of 3-mercaptopropionic ester avoids the defects of dangerous operation of hydrogen sulfide introduction under high pressure and difficult treatment of wastewater in the traditional production process of 3-mercaptopropionate. The method provided by the invention is a green chemical synthesis method, which has no pollution and high raw material utilization rate.

A method for producing 3-mercaptopropionic acid and methods using same for producing a carbonic acid ester compound having a mercapto group and a thiourethane-based optical material. The present invention improves a process during the production of 3-mercaptopropionic acid, significantly increases yield, and reduces the temperature and time during vacuum distillation, thereby preventing the destruction of a product and significantly increasing productivity. The present invention allows high-purity 3-mercaptopropionic acid having an excellent color to be finally yielded; accordingly, by using same, a high-purity carbonic acid ester compound having an excellent color and a mercapto group can be inexpensively obtained. A thiourethane-based polymeric composition and a thiourethane-based optical material obtained by polymerizing same can likewise be inexpensively obtained by using said carbonic acid ester compound. Such carbonic acid ester compound can be used for the production of inexpensive thiourethane optical lenses; consequently, inexpensive optical lenses having an excellent color can be obtained.

The invention belongs to the field of synthesis of sulfhydryl compounds and in particular relates to a synthesis method of 3-mercaptopropionic acid. The method comprises the following steps: (1) adding acrylic acid into a gasification chamber according to a pre-set flow; introducing hydrogen sulfide and acrylic acid into a mixer according to a certain mol ratio and uniformly mixing; (2) starting a plasma reactor filled with a catalyst and introducing mixed gas into the plasma reactor to react; controlling reaction temperature and pressure; (3) after reaction is finished, cooling and rectifying to obtain the 3-mercaptopropionic acid. The method provided by the invention can be used for effectively synthesizing the 3-mercaptopropionic acid; a whole synthesis process is carried out under -0.05MPa to 0.1MPa; a technology is simple and can realize continuous operation. An experiment result shows that the average yield of the method provided by the invention on the 3-mercaptopropionic acid is 78.77 percent.