The invention relates to high-stability coal water slurry and a preparation method thereof. The coal water slurry contains coal powder, an additive, a stabilizer and water and has the mass concentration of 64-70 percent, wherein antibiotic fungi residues are adopted as the stabilizer, the addition of a fungi residue dry base is 0.1-1.5 percent of the total mass of a coal powder dry base and the fungi residue dry base, the addition of the additive is 1.0-2.0 percent of the mass of the coal water slurry, and the rest is water, and the antibiotic fungi residue comprises lincomycin wet bacteria residues, gentamicin wet bacteria residues and penicillin wet bacteria residues. In the preparation process of the coal water slurry, the antibiotic fungi residues are added, have less viscosity influence on the coal water slurry, but can remarkably decrease the syneresis rate of the coal water slurry and improve the stability of the coal water slurry, the slurry can be placed for a long time, and the requirements for pumping, atomizing, transporting in various modes, combusting and gasifying can be met. The method has low cost, not only can improve the stability of the coal water slurry, but also provides a new path for solving the problem of environmental pollution due to the antibiotic fungi residues.