1results about How to "Reduce biomass" patented technology

The application discloses an enzyme-triggered self-assembly peptide hydrogel, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The hydrogel comprises a peptide precursor Nap-YY(p)Y, an antibacterial compound daphnodorin and alkaline phosphatase; the peptide precursor is dephosphorylated under the action of the alkaline phosphatase, self-assembled to form a nanofiber network structure, and encapsulates the daphnodorin in the network structure. The hydrogel has a short gelation time (3-10 minutes), a moderate mechanical strength (a storage modulus G' of 130-170 Pa), a high encapsulation rate (greater than or equal to 75%), presents a biphasic release characteristic in a simulated wound liquid, and can maintain an effective therapeutic concentration for more than 7 days. The hydrogel has a significant synergistic killing effect on methicillin-resistant Staphylococcus aureus and a biofilm thereof, can effectively reduce a bacterial load of a wound and accelerate wound healing.