The invention relates to a high-precision drilling multi-pore clamping device which comprises a bottom plate, a drill bushing bracket and one group of drill bushing, wherein a vertical slab is arranged on the bottom plate, a positioning block is fixedly arranged on the bottom plate at the right side of the vertical slab, a workpiece positioning region is formed between the positioning block and the vertical slab, the drill bushing bracket is arranged at the upper part of the vertical slab, and one group of drill bushing positioned above the workpiece positioning region is arranged on the drill bushing bracket. The high-precision drilling multi-pore clamping device has the advantages of simple structure, scientific design, simpleness in use, capability of completing multiple procedures through once clamping, high machining speed, high efficiency, high precision and the like.