The invention discloses meal replacement powder. The meal replacement powder is prepared by mixing the following seven powder materials in parts by weight: brassica campestris powder, five-cereal powder, vegetable powder, fruit powder, shelled melon-seed powder, fructo-oligosaccharide powder and medicinal and edible powder. The meal replacement powder disclosed by the invention has the beneficialeffects that the meal replacement powder is rich and diverse in variety, comprehensive and balanced in nutrition and free of any additive, so that various nutrients required by a human body can be guaranteed, and sub-health is prevented; and the meal replacement powder disclosed by the invention contains rich dietary fiber, and the content of fat, carbohydrates and protein is not high, so that long-term eating not only can make the indexes including weight, blood pressure, blood fat, blood sugar and the like further increase, but is conducive to weight loss, blood fat reduction and blood pressure reduction, and accordingly, the body basic metabolism is improved, various diseases are prevented from being induced, so that the meal replacement powder can be eaten as three meals a day.