The invention relates to a traditional Chinese medicine treating IgA nephrosis and application of the traditional Chinese medicine. The traditional Chinese medicine comprises, by weight, 9-15 parts of rehmannia, 9-15 parts of tortoise plastron, 9-15 parts of glossy privet fruit, 15-25 parts of eclipta prostrate, 5-15 parts of pollen typhae, 12-18 parts of rhizoma atractylodis, 12-18 parts of bighead atractylodes rhizome, 25-35 parts of oldenlandia diffusa, 25-35 parts of semen coicis and 10-18 parts of Chinese yam, or comprises, by weight, 9-15 parts of rehmannia, 9-15 parts of tortoise plastron, 9-15 parts of glossy privet fruit, 15-25 parts of eclipta prostrate, 25-35 parts of oldenlandia diffusa and 5-15 parts of pollen typhae. The drug matching is appropriate, the traditional Chinese medicine has the effects of nourishing the kidney, tonifying the spleen, clearing heat and nourishing yin, the deposition of CD44 in glomerulus can be effectively reduced, and therefore the traditional Chinese medicine can be used for treating the IgA nephrosis and delaying the development of the IgA nephrosis, meanwhile, the number of the herbal medicines in a prescription of the traditional Chinese medicine is small, preparing is convenient, cost is low, the traditional Chinese medicine is prepared through pure traditional Chinese medicine, toxic and side effects do not exist, and the traditional Chinese medicine can be accepted by patients easily.