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64results about How to "Relatively small molecular mass" patented technology

A kind of separation method of oil sludge sand

The invention discloses a method for separating oily sludge and sands, which comprises the steps of: in the presence of water, carrying out a contact reaction on the oily sludge and sands and a catalyst and an oxidizing agent, and separating to obtain a water phase, a grease phase and sand, wherein the oxidizing agent is a matter capable of oxidizing grease in the oily sludge and sands and reducing the viscosity of the oily sludge and sands, and the catalyst is a matter capable of promoting the oxidizing agent to generate radicals with strong oxidability. According to the method for separating the oily sludge and sands, provided by the invention, the content of oil in oily sludge and sands can be remarkably reduced, therefore, grease, sand and water in oily sludge and sands can be effectively and efficiently separated.
Owner:CHINA PETROLEUM & CHEM CORP +1

Ultrasonic plasticizing capillary rheometer and viscosity test method

An ultrasonic plasticizing capillary rheometer comprises a frame, a rheological test unit, an ultrasonic vibration apparatus, and a tool head moving and loading unit. The ultrasonic vibration apparatus is provided with an ultrasonic tool head capable of extending into a plasticizing chamber along an axial direction, providing extrusion force for polymer in the plasticizing chamber, and providing ultrasonic wave energy required by the polymer for fusion from a solid state to a liquid state. In the ultrasonic plasticizing capillary rheometer, three steps including heating fusion, ultrasonic vibration for fluidity increase, and material extrusion are completed through the ultrasonic tool head and in the plasticizing chamber, thereby simplifying the conveying path. A heating ring providing the required initial temperature for the plasticizing process sleeves a material canister, provides a constant material canister temperature for the rheometer, and reduces the test error. A filter screen is arranged in the material canister, centralizes fused polymer, and improves the test accuracy. During a test process, a viscosity test method is accurate in heating, short in fusion time, and wide in application range, is slightly affected by the external environment, and can provide viscosity data high in accuracy.
Owner:CENT SOUTH UNIV

Wood adhesive prepared by degrading soybean protein by utilizing strong basicity and preparation method thereof

The invention discloses a wood adhesive prepared by degrading soybean protein by utilizing strong basicity and a preparation method thereof, and relates to a soybean protein-based wood adhesive and a preparation method thereof. The invention solves the problems of low content of the soybean protein, high moisture content and large viscosity existing in conventional soybean adhesives or soybean protein adhesives. The product is prepared by performing a degradation reaction of defatted soybean protein powder or soybean protein isolate, strong base and water, then using strong phosphoric acid to adjust the pH value of the obtained solution, and then adding dialdehyde into the obtained solution to mix the solution evenly. The method comprises the steps of: 1, weighing; 2, preparing strong base solution, heating the strong base solution, adding the defatted soybean protein powder or the soybean protein isolate into the strong base solution under stirring, and then cooling the strong base solution to a room temperature after heating reflux; and 3, using the strong phosphoric acid to adjust the pH value, adding the dialdehyde into the solution, and stirring the solution evenly. The adhesive has the advantages of high content of the soybean protein, low moisture content and low viscosity, and can be used for preparing plywood, flakeboards and medium-density fiberboards.
Owner:NORTHEAST FORESTRY UNIVERSITY

Method for manufacturing rose honey-containing collagen polypeptide tea

The invention discloses a method for manufacturing rose honey-containing collagen polypeptide tea and belongs to the technical field of food resource development and processing. The method comprises the following steps of: by taking collagen polypeptide, rose leaching solution leached by combining superfine grinding assist and honey, matching pure water, adding a proper amount of flavoring rose essence and pigment, ultrasonically homogenizing, and manufacturing the rose honey-polypeptide tea; leaching the rose juice by adopting the assisted superfine grinding technology; ultrasonically homogenizing the composite drink; and mixing the tea drink and optimizing the sterilization process. The tea drink mainly comprises honey, rose, collagen and other natural components, so that the tea is enriched in vitamins, mineral substances, proteins, amino acids and the like, the content of fat and heat is low, and the effects of maintaining beauty and keeping young can be achieved. The rose honey-containing collagen polypeptide tea is scientific in formula, rich in nutrition and moderate in sweetness and sourness. The preparation method is reasonable in process, easy to operate, short in production cycle and suitable for industrial production.
Owner:GUANGDONG JIAHAO FOOD +1

Water-based acrylic polyurethane paint and preparation method thereof

InactiveCN105969151AEasy constructionDoes not increase VOC contentPolyurea/polyurethane coatingsWater basedEmulsion
The invention discloses a water-based acrylic polyurethane paint and a preparation method thereof. The water-based acrylic polyurethane paint is prepared from a component A and a component B, wherein the component B is a curing agent; and the component A is prepared from the following components in percentage by weight: 35%-45% of water-based acrylic emulsion, 0.5%-1.2% of a wetting dispersant, 0.1%-0.5% of a defoaming agent, 10%-20% of a pigment, 10%-18% of talc powder, 10%-18% of barium sulfate, 0.3%-0.8% of a flatting agent, 0.1%-0.5% of a rheological aid and 10%-15% of deionized water. The system is low in solvent content and VOC content, and a paint film is rapidly dried and good in rubbing property.
Owner:HEBEI CHENYANG INDAL & TRADE GROUP CO LTD

Nanorealgar-carrying magnetic albumin nanospheres and preparation method thereof

The invention discloses nanorealgar-carrying magnetic albumin nanospheres and a preparation method thereof. The method comprises the following steps of preparing iron oxide nanoparticles and nanorealgar by an improved chemical coprecipitation process; preparing nanorealgar-loaded magnetic albumin nanospheres by a desolvation-crosslinking process. The method is simple and easy to implement, integrates the advantages of thermal therapy, chemotherapy, thermal release control, magnetic targeting and the like through albumin nanospheres, and develops a new idea for tumor therapy. Apart from a therapy carrier, the novel nanocarrier also can be used for the in-vivo magnetic resonance imaging study to provide reliable experimental study data and theoretical basis to the clinical application and study.
Owner:SOUTHEAST UNIV

Staphylococcus aureus enterotoxin A nano antibody A13 and application and kit of nano antibody A13

The invention discloses a staphylococcus aureus enterotoxin A (SEA) nano antibody A13 and application and a kit of the nano antibody A13. The nano antibody has small relative molecular mass, strong stability and high yield, can specifically recognize SEA, and has wider application and stronger specificity than conventional monoclonal antibodies. The invention discloses the nano antibody, a gene sequence encoding the nano antibody, a method for producing the nano antibody and a kit using the nano antibody. The nano antibody can avoid binding with staphylococcus aureus surface protein A, shows high specificity, has good stability and small molecular weight, and can be produced on a large scale.
Owner:NORTHWEST A & F UNIV

Method for reducing viscosity of crude oil

The invention provides a method for reducing the viscosity of crude oil, which comprises the following steps: injecting water into the crude oil and adding a catalyst and an oxidant, then mixing the mixture evenly. By oxidating a part of the crude oil by a catalytic oxidation method, the method reduces the relative molecular mass of the crude oil, thereby reducing the viscosity of the crude oil, ensuring that the crude oil is easy to be displaced, and further increasing the recovery ratio.
Owner:CHINA PETROLEUM & CHEM CORP +1

Bioabsorbable polyphosphoester amino acid copolymer material

The invention discloses a bioabsorbable polyphosphoester amino acid copolymer material, which is formed by preparing caprolactam, alpha-amino acid and phosphate, wherein caprolactam and alpha-amino acid are firstly polymerized to form a polybasic amino acid amide structural polymer; the polybasic amino acid amide structural polymer and phosphate are formed to be polyphosphoester amino acid copolymer. The polyphosphoester amino acid copolymer has good hydrophilia and degradation property, excellent physical performance, and can reduce the pH value of the product to 6.5-7.5 without stimulus response; the effect of internal repair is good, and the clinical application prospect is good.
Owner:SICHUAN GUONA TECH

Wood adhesive prepared by degrading soybean protein by utilizing strong basicity and preparation method thereof

The invention discloses a wood adhesive prepared by degrading soybean protein by utilizing strong basicity and a preparation method thereof, and relates to a soybean protein-based wood adhesive and a preparation method thereof. The invention solves the problems of low content of the soybean protein, high moisture content and large viscosity existing in conventional soybean adhesives or soybean protein adhesives. The product is prepared by performing a degradation reaction of defatted soybean protein powder or soybean protein isolate, strong base and water, then using strong phosphoric acid toadjust the pH value of the obtained solution, and then adding dialdehyde into the obtained solution to mix the solution evenly. The method comprises the steps of: 1, weighing; 2, preparing strong base solution, heating the strong base solution, adding the defatted soybean protein powder or the soybean protein isolate into the strong base solution under stirring, and then cooling the strong base solution to a room temperature after heating reflux; and 3, using the strong phosphoric acid to adjust the pH value, adding the dialdehyde into the solution, and stirring the solution evenly. The adhesive has the advantages of high content of the soybean protein, low moisture content and low viscosity, and can be used for preparing plywood, flakeboards and medium-density fiberboards.
Owner:NORTHEAST FORESTRY UNIVERSITY

Application of biologically absorbable polyphosphate and amino acid copolymer material

The invention discloses application of a biologically absorbable polyphosphate and amino acid copolymer to preparation of a repairing material. The polyphosphate and amino acid copolymer is prepared from caprolactam, alpha-amino acid and phosphate, wherein the caprolactam and the alpha-amino acid are firstly polymerized to form a polymer with a multi-component amino acid amide structure; the polymer with the multi-component amino acid amide structure and the phosphate form the polyphosphate and amino acid copolymer. The invention further discloses a blend formed by the polyphosphate and amino acid copolymer and other materials. The polyphosphate and amino acid copolymer is used as the repairing material and has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing, and can also form the blend with other materials; the polyphosphate and amino acid copolymer has good clinical application prospect.
Owner:SICHUAN GUONA TECH

Novel water-based automobile surface lacquer

The invention discloses a preparation method of a novel water-based automobile surface lacquer. The novel water-based automobile surface lacquer adopts purified water as a solvent and two-component waterborne polyurethane as a bonding material, and is added with a graphene filler, so that through the cooperation of reasonable component ratio and the filler, the prepared water-based automobile surface lacquer not only is friendly to environment, but also further promotes the improvement of a thermal property, a mechanical property and a hydrophobic performance. The surface lacquer is rich in water-based resin, so that the dosage of a toxic nonpolar reagent is reduced, the emission of VOC (Volatile Organic Compounds) is effectively controlled, the adhesive force is high, the surface lacquer is safe and environmentally-friendly, the hardness of a film is high, the weather fastness, the heat resistance and the hydrophobic property of the whole surface lacquer are greatly improved, and the surface lacquer has excellent performances of ultraviolet resistance, acid rain resistance, wear resistance, scratch resistance and the like. The film is bright-colored, clear, attractive and elegant.
Owner:福建格林春天新材料股份有限公司

Staphylococcal enterotoxin B nano antibody B1, application thereof and kit

The invention discloses a staphylococcal enterotoxin B nano antibody B1, an application thereof and a kit. The nano antibody obtained by the invention has the advantages of small relative molecular mass, strong stability and high yield, can specifically recognize SEB, and has wider application and stronger specificity than the conventional monoclonal antibody. The invention discloses the nano-antibody, a gene sequence for encoding the nano-antibody, a method for producing the nano-antibody and a kit applying the antibody. The nano antibody obtained by the invention can be prevented from beingcombined with staphylococcus aureus surface protein A, shows higher specificity, has good stability and small molecular weight, and can be produced on a large scale.
Owner:NORTHWEST A & F UNIV

Method for preparing ACE (Angiotensin Converting Enzyme) inhibitory peptide by hydrolyzing rice protein isolate with complex enzyme

The invention discloses a method for preparing an ACE (Angiotensin Converting Enzyme) inhibitory peptide by hydrolyzing rice protein isolate with a complex enzyme. The method comprises the following steps of: (1) adjusting temperature of rice protein isolate aqueous solution with mass-volume concentration of 5-8 percent to 45-55 DEG C and pH (Potential of Hydrogen) value to 8.5-9.5, and adding alkaline protein enzyme according to an enzyme adding amount of 48-60 AU / kg to hydrolyze for 120-150 min; (2) adjusting system temperature to 36-38 DEG C and pH value to 7-8 and adding trypsin according to an enzyme adding amount of 12.5-25 USP / kg to hydrolyze for 30-60 min; and (3) adjusting the pH value to 5.0-5.5 and performing solid-liquid separation, ultrafiltration membrane screening, desalting, concentration and freeze drying on enzymatic hydrolysate in sequence to prepare the ACE inhibitory peptide product. According to the method, two enzymes act on different enzyme cutting sites respectively; the prepared ACE inhibitory peptide has high yield and strong activity; and the method has the advantages of simple process, mild reaction condition and contribution to industrial production.
Owner:WUHAN POLYTECHNIC UNIVERSITY

Novel polypeptide for tumor targeting and application thereof

The invention belongs to the field of biomedicine, and particularly relates to a novel polypeptide with a targeting effect on human ovarian cancer cells and application thereof. The amino acid sequence of the polypeptide is WNPLLLTRLLPA(SEQ ID No.1), and in the polypeptide molecule, through deletion, insertion or displacement of one or several amino acids, a polypeptide derivative with the same biological function as the polypeptide molecule is obtained. The polypeptide has the advantages of small molecular mass, high permeability, high specificity, low costs and the like, and shows unique advantages in tumor targeting diagnosis and treatment.
Owner:中国医科大学

Chicken marrow-derived dendritic cell (DC) targeting peptide AH and application thereof

The invention discloses a chicken marrow-derived dendritic cell (DC) targeting peptide AH and an application thereof. The amino acid sequence of the chicken marrow-derived DC targeting peptide AH is shown as SEQ ID NO.1. A chicken marrow-derived DC dominant binding peptide AH is sieved by using a phage random peptide library and a whole cell differential screening technology, the peptide can be relatively strongly bound to a chicken marrow-derived DC to show good targeting properties and specificity, and therefore, the targeting peptide can be used as a lead molecule of a drug such as a gene leading carrier to lay the foundation for specific small molecular therapy of a cell or can be combined with a vaccine to increase the immunization efficiency of an avian vaccine and promote organismsto generate immunities in advance.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Hair washing, face cleaning and bathing three-in-one purification cream and method for preparing same

The invention provides hair washing, face cleaning and bathing three-in-one purification cream. The hair washing, face cleaning and bathing three-in-one purification cream comprises laureth disodium stearamido mea-sulfosuccinate, potassium cocoyl glycinate, cocamidopropyl betaine, cocamide MEA (monoethanolamine), polyethylene glycol-14M, hydrolyzed collagen, silk sericin, lycine salicylate, glycol distearate, PEG-150 (polyethylene glycol-150) distearate, allantoin, phenoxyethanol, DMDM (dimethylol dimethyl) hydantoin, bamboo charcoal, peppermint oil, menthol, glycerin, essence, sodium chloride, citric acid, EDTA (ethylene diamine tetraacetic acid) disodium and the balance water. The invention further provides a method for preparing the hair washing, face cleaning and bathing three-in-one purification cream. The hair washing, face cleaning and bathing three-in-one purification cream and the method have the advantages that the production cost can be reduced; fatty alcohol polyether alkyl sulfate is replaced by the laureth disodium stearamido mea-sulfosuccinate and the potassium cocoyl glycinate, and the cleaning power can be enhanced under the synergistic effect of the bamboo charcoal; amino acid surfactant mixed systems are extremely low in irritation, subcutaneous tissues can be effectively nourished by the hydrolyzed collagen and the silk sericin, and the hair washing, face cleaning and bathing three-in-one purification cream which is a product is safe and is convenient to carry.
Owner:佛山市富馨科技实业有限公司

Glue-permeation-free plant protein sucrose-based environment-friendly adhesive for plywood as well as preparation method and application of glue-permeation-free plant protein sucrose-based environment-friendly adhesive

The invention discloses a glue-permeation-free plant protein sucrose-based environment-friendly adhesive for plywood. The adhesive comprises the following components in parts by weight: 100 parts of sucrose; 20-40 parts of ammonium dihydrogen phosphate; 3-4 parts of sodium pyrosulfite; 2-4 parts of sodium carboxymethyl cellulose; 0.03-1 part of sodium dodecyl benzene sulfonate; 4-5 parts of boric acid; 3-5 parts of potassium hydroxide; 0.5-2 parts of citric acid; 10-25 parts of defatted soybean protein; 10-25 parts of dephenolized cottonseed protein and 27-55 parts of water. The invention further discloses a preparation method of the glue-permeation-free plant protein sucrose-based environment-friendly adhesive for the plywood and an application of the glue-permeation-free plant protein sucrose-based environment-friendly adhesive to preparation of the plywood. According to the glue-permeation-free plant protein sucrose-based environment-friendly adhesive for the plywood as well as the preparation method and the application of the glue-permeation-free plant protein sucrose-based environment-friendly adhesive, the glue permeation defect occurring when a traditional sucrose-based adhesive is used for preparing the plywood is overcome, and the problem of glue permeation on the surface of the plywood is obviously solved.
Owner:NANJING FORESTRY UNIV

Eczema ointment and preparation method thereof

The invention discloses an eczema ointment and a preparation method thereof. The method comprises the following steps that 1) periostracum cicada, astragalus membranaceus, angelica sinensis, frankincense, myrrh, realgar and golden larch bark are smashed and immersed, and heat-under-reflux is carried out; filtering is carried out, a solvent is evaporated to obtain a Chinese herbal extract I; 2) decoction is conducted on wormwood and chrysanthemum indicum, and concentration is carried out to obtain a water extract II; 3) the Chinese herbal extract I, the water extract II, lotus seed powder and honey are mixed to prepare a mixed medicament III; 4) glycerin monostearate and aloe vera gel are mixed to be conducted with ultrasonication and heating to obtain a solution IV; 5) tacrolimus and a dispersing agent are mixed with a mixed liquid, and the solvent is evaporated to obtain a crude eczema ointment; 6) after high pressure homogenization is conducted on the crude material, the eczema ointment is obtained. The prepared eczema ointment has the functions of clearing damp, relieving itching, regulating immunity, preventing inflammatory and itch, clearing heart fire, tranquilizing mind by nourishing the heart, activating blood circulation, regulating qi, relieving pain, eliminating swelling, eliminating stagnation, promoting tissue regeneration, turning fester caused by pruritus and empyesis into tissue regeneration, and effecting a radical cure without any side effects.
Owner:陈雨薇

Preparation method and application of UTY antibody nano-particles for fast separation of X/Y sperms of cattle and sheep

The invention discloses a preparation method and an application of UTY antibody nano-particles for fast separation of X / Y sperms of cattle and sheep. The preparation method comprises steps as follows: a monoclonal antibody resisting a Y sperm UTY antigen is prepared from Y sperm UTY antigen recombinant protein; the monoclonal antibody is subjected to enzyme digestion by pepsase, and Fab' fragments resisting an anti-UTY antigen are obtained through separation; calcium phosphate nano-particles containing the Fab' fragments are prepared. The prepared UTY antibody nano-particles have the capacity of performing antigen-antibody reaction on the surfaces of the Y sperms and inside the Y sperms, thereby leading to Y sperm agglutination, the separation efficiency of X / Y sperms reaches 80%-95%, and the UTY antibody nano-particles have the characteristics of simple, fast and cheap X / Y sperm separation, high efficiency and the like and has extremely small damage.
Owner:NORTHWEST A & F UNIV

Multi-component composite peptide solid beverage and preparation method of solid beverage

The invention discloses a multi-component composite peptide solid beverage and a preparation method of the solid beverage, and relates to the technical field of solid beverage preparation. Aiming at the technical problems of few types and single function of the existing peptide beverage, the invention provides the multi-component composite peptide solid beverage which is prepared by carrying out multi-component compounding on bovine bone peptide, sea cucumber peptide and walnut peptide, and adding edible and medicinal Chinese herbal medicines such as chestnuts, wild jujubes, Chinese wolfberryfruits, etc. The multi-component composite peptide solid beverage prepared by the invention can increase bone strength, improve human body immunity, resist fatigue, tonify qi, nourish blood, benefit intelligence and strengthen brain. The solid beverage is simple and convenient to eat, and is a health-care solid beverage with high nutritional value.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Auxiliary-dyeing environmental amphoteric fatliquoring agent and preparation method thereof

The invention discloses an auxiliary-dyeing amphoteric fatliquoring agent preparation method, which includes the following specific steps: firstly esterifying fatty acid with N-methyldiethanolamine; esterifying and modifying a system with maleic anhydride; and then preforming a sulfite sulfonation reaction to obtain a linear amphoteric fatliquoring agent containing carboxyl, sulfonic acid group and tertiary amine in a molecular structure. A fatliquoring result shows that after the blue wet leather is treated by the auxiliary-dyeing amphoteric fatliquoring agent, the depth and concentration ofthe color of the crust leather are improved. The tertiary amine group on the fatliquoring agent can be positively charged after being protonated by acid, can provide more binding points for anionic dyes, and has a hyperchromic effect.
Owner:广东西顿新材料科技有限公司

Preparation method of biologically absorbable polyphosphate and amino acid copolymer material

The invention discloses a preparation method of a biologically absorbable polyphosphate and amino acid copolymer material. The preparation method comprises the following steps: 1) dehydrating alpha-amino acid and caprolactam under the protection of inert gas at 150 DEG C to 200 DEG C; 2) reacting at 190 DEG C to 260 DEG C and finishing polymerization reaction to form a polymer with a multi-component amino acid amide structure; 3) adding phosphate and reacting at 200 DEG C to 260 DEG C for 0.5h to 2h and finishing ring-opening copolymerization reaction; cooling to room temperature under the protection of the inert gas to obtain a product. A polyphosphate and amino acid copolymer prepared by the method has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing and has good clinical application prospect.
Owner:SICHUAN GUONA TECH

High-temperature-curing inorganic anticorrosive coating for automobile brake disc

The invention relates to the technical field of anticorrosive paint, in particular to high-temperature-curing inorganic anticorrosive coating for an automobile brake disc and a preparation method thereof. The inorganic anticorrosive coating comprises the following components in parts by mass: 40-45 parts of inorganic resin, 3-5 parts of modified zinc phosphate, 5-6 parts of composite ferrotitaniumpowder, 3-4 parts of a curing agent, 10-15 parts of water, 20-25 parts of talcum powder, 0.8-2 parts of dispersing agents, 0.5-0.8 part of a defoaming agent, 0.5-1 part of a neutralizing agent and 0.5-1 part of bentonite. According to the inorganic anticorrosive coating, on the premise that coating thickness is 30 microns, salt spray resistance time can reach 1000 hours, and adhesive force is good; different types of dispersing agents are selected, so the influence on the salt spray resistance of a paint film is very outstanding; a hydrophobic ammonium salt forms a good water-resistant film,and a sodium salt hydrophilic dispersing agent is low in relative molecular mass, so the water resistance and salt fog resistance of a coating film are reduced; and the polycarboxylate ammonium salt with a special structure and high relative molecular mass is selected as the dispersing agent, so the corrosion resistance of the coating is remarkably improved.
Owner:Jiangsu Jiunuo Architectural Materials Technology Co Ltd

Surface sterilization antiviral spray as well as preparation method and application thereof

The invention discloses a surface sterilization antiviral spray for oropharynx, face and hands. The surface sterilization antiviral spray is prepared from lysozyme, tetrapyridinium chloride, glycyrrhizic acid, acesulfame potassium, menthol and hydrogen-rich water. The invention also discloses application of the spray as a medicine product on the oropharynx, face and / or hands for surface sterilization and virus resistance, especially resistance to novel coronavirus SARS-CoV-2. The spray has the advantages of broad-spectrum disinfection, extremely strong seepage force, high acting speed, good stability, low toxicity, no corrosion, small irritation and good environment-friendly feature, and is particularly easy to form a layer of invisible protective film on the surface of oral mucosa, face and skin, especially on the surface of a hand, so that the infection from bacteria and viruses is effectively prevented, and the long-time antibacterial and antiviral effects are achieved. Therefore, the surface sterilization antiviral spray has a wide application prospect.
Owner:山东莱博生物科技有限公司

Preparation method of lentinan

The invention belongs to the technical field of biological extraction, and particularly relates to a preparation method of lentinan. The method comprises the following steps: taking pasania fungus, purifying, washing, draining off and cutting; secondly, performing high pressure treatment; thirdly, performing ultrasonic extraction; and fourthly, performing ultrafiltration, concentrating, alcohol precipitation and centrifugation, discarding supernatant, and performing vacuum freeze drying, so as to obtain the lentinan. The lentinan prepared through the method is high in extraction ratio, and various efficacies, such as anticancer efficacy, antioxidant efficacy and blood fat reducing efficacy, of the lentinan can be improved.
Owner:高枫

Novel polypeptide specifically bound with multiple tumor cells and application thereof

The invention belongs to the field of biomedicine, and particularly relates to a novel polypeptide specifically bound with multiple tumor cells and application thereof. The amino acid sequence of thepolypeptide is selected from an amino acid sequence shown as one of SEQ ID NO. 1 to SEQ ID NO. 5. The polypeptide and bioactive fragments and derivatives thereof are applied to tumor diagnosis and treatment as molecular imaging probes and drug target heads. The polypeptide disclosed by the invention has the effects of specifically targeting various cancer cells, and is high in specificity and small in side effect, so that a series of tumor early diagnosis reagents and targeted treatment drugs are developed, and a new direction is opened up for designing and researching novel tumor targeted drugs.
Owner:中国医科大学

Specific antibody of new coronavirus S protein NTD region as well as preparation method and application of specific antibody

The invention relates to an antigen binding protein, an antibody or an antibody active fragment obtained by immunizing a camelidae animal by using an S protein NTD region of SARS-Cov-2. According to the invention, the antibody which specifically recognizes and is combined with the NTD region of the S protein on the surface of the new coronavirus is screened, identified and prepared by virtue of an immune system of a camelidae animal, the obtained antibody is high in affinity and specifically recognizes and is combined with the NTD region, and the region is a part with relatively great difference between the S protein of the new coronavirus and other coronavirus sequences, so that the new coronavirus S protein can be specifically recognized and combined with the NTD region. The method can be used as a marker for distinguishing a new coronavirus from other coronaviruses. The antibody is developed aiming at the NTD region of the S protein, so that the new coronavirus and other coronaviruses are expected to be specifically distinguished, and the diagnosis of patients and the implementation of symptomatic treatment measures are facilitated.
Owner:BIOISLAND LAB +1

An ultrasonic plasticizing capillary rheometer and viscosity testing method

An ultrasonic plasticizing capillary rheometer comprises a frame, a rheological test unit, an ultrasonic vibration apparatus, and a tool head moving and loading unit. The ultrasonic vibration apparatus is provided with an ultrasonic tool head capable of extending into a plasticizing chamber along an axial direction, providing extrusion force for polymer in the plasticizing chamber, and providing ultrasonic wave energy required by the polymer for fusion from a solid state to a liquid state. In the ultrasonic plasticizing capillary rheometer, three steps including heating fusion, ultrasonic vibration for fluidity increase, and material extrusion are completed through the ultrasonic tool head and in the plasticizing chamber, thereby simplifying the conveying path. A heating ring providing the required initial temperature for the plasticizing process sleeves a material canister, provides a constant material canister temperature for the rheometer, and reduces the test error. A filter screen is arranged in the material canister, centralizes fused polymer, and improves the test accuracy. During a test process, a viscosity test method is accurate in heating, short in fusion time, and wide in application range, is slightly affected by the external environment, and can provide viscosity data high in accuracy.
Owner:CENT SOUTH UNIV

Novel polypeptide targeting multiple tumor cells and application of novel polypeptide

The invention belongs to the field of biomedicine, relates to a polypeptide in targeted binding with tumor cells and particularly relates to the polypeptide in specific binding with multiple tumor cells as well as application of the polypeptide in tumor prevention, treatment and diagnosis. An amino acid sequence of the polypeptide is selected from an amino acid sequence shown in one of SEQ ID NO.1-SEQ ID NO.5. The polypeptide and bioactive fragments and derivatives thereof are applied in diagnosis and treatment of tumors as molecular image probes and medicine target heads. The polypeptide hasa function of specifically targeting the multiple tumor cells and is high in specificity and weak in side effects, so that a series of earlier-stage diagnosis reagents and targeted therapy medicines for tumors are developed, and a new direction is opened for design, research and development of novel tumor targeted medicines.
Owner:中国医科大学
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