The invention discloses a manufacturing method of a fireproof insulation board. The manufacturing method of the fireproof insulation board is characterized in that a plurality of holes are punched in a polystyrene foam board; 2) a fireproof insulation pouring material is prefabricated, wherein the fireproof insulation pouring material is prepared from the following components in parts by weight: 100-200 parts of Portland cement, 10-20 parts of fluorite slag powder, 10-20 parts of superfine slag powder, 40-60 parts of cinder aggregate, 40-50 parts of aluminum oxygen chamotte, 20-30 parts of asbestos fiber, 5-10 parts of calcined diatomite, 5-10 parts of simethicone, 2-4 parts of liquid paraffin, 2-4 parts of aluminium hydroxide, 2-4 parts of asbestos fiber, 3-5 parts of cellulose ether and 2-3 parts of brucite powder; 3) the prefabricated pouring material is added in the holes, the holes are sealed by a fireproof sealant after adding the pouring material, and the product is dried. According to the manufacturing method of the fireproof insulation board, the anti-burning property of the insulation board is greatly improved, the smoke volume and the smoke toxin produced by the polystyrene foam board are greatly reduced, and the fireproof insulation board further has an excellent thermal insulation effect and a waterproof property.