The invention discloses health wine with a healthcare function. The health wine is prepared from materials including Chinese yam, medlar, poria cocos, fructus crataegi, gineng, radix codonopsis, angelica sinensis, jujubes, gingko, astragalus membranaceus, lucid ganoderma, pericarpium citri reticulatae, semen cassiae, radix puerariae, wine and oligomerization mannose powder. The preparation method includes material preparation, smashing, boiling out, soaking and sealed preservation. The health wine with the healthcare function has obvious effect in protecting the intestinal, improving immunity, relieving insulin burdens, improving insulin action, improving serum, improving microcirculation, and protecting and regulating organ function and has efficacies of replenishing qi and nourishing blood, regulating blood fat, reducing blood sugar and promoting hematopoietic function. Technological parameters for preparation of the health wine are further improved, high-temperature soaking and low-temperature storage are adopted, effective availability of drugs is further increased, taste of the wine is further improved, and greater efficacies can be played. The preparation method is simple in operation, convenient to prepare, low in cost and suitable for industrialized mass production.