385 results about "Bifidobacterium animalis lactis" patented technology

The present invention discloses a traditional Chinese drug microecology composition. According to the present invention, specifically mongolian milkvetch root, largehead atractylodes rhizome, divaricate saposhnikovia, dangshen, coptis chinensis, folium isatidis, weeping forsythia fruit, honeysuckle, heartleaf houttuynia herb, chinese thorowax root, common selfheal spike, cassia and a licorice root extraction liquid are adopted to culture Bacillus subtilis, Bnfillus licheniformis, animal Bacillus bifidus, lactic acid bacteria and Saccharomyces cerevisiae microbe to obtain the composite microecology traditional Chinese drug composition, wherein the composite microecology traditional Chinese drug composition has characteristics of green, safety, low cost, inhibition effects on harmful microorganisms in animal intestines, and improvement of non-specific immune function, provides a certain prevention and treatment effect for viral diseases, can be used as a livestock feed additive, and can further be used separately.

The invention discloses bifidobacterium longum and applications thereof, and belongs to the technical field of microorganisms. The bifidobacterium longum is deposited in the China General Microbiological Culture Collection Center in Institute of Microbiology, Chinese Academy of Sciences at number 3, No.1 yard, Beichenxi road, Chaoyang district, Beijing on December 7, 2017, and the accession numberis CGMCC NO.15032. The bifidobacterium longum has good growth, acid production, and acid resistant properties, and high adhesive capacity, can significantly increase the water content of faeces and the pushing rate of small intestine of mice with constipation, shortens the first black stool evacuation time, relieves inflammation of colonic mucosas, and regulates contents of gastrointestinal peptides related to constipation in serum. A constipation relieving effect of the bifidobacterium longum is equivalent to that of bifidobacterium animalis BB12, but an effect of the bifidobacterium longumon the pushing rate of small intestine is superior to those of bifidobacterium animalis BB12 and phenolphthalein. Accordingly, the bifidobacterium longum strain CCFM760 can be widely applied in various foods or medicine matrixes.

The invention relates to an animal Bifidobacterium and a use method thereof. The animal Bifidobacterium is the Bifidobactrium amimalis Subsp Lactis B174, the CGMCC No. is 4182, the conservation date is September 16, 2010 and the conservation unit is the China General Microbiological Culture Collection Center. The Bifidobactrium amimalis Subsp Lactis B174 can colonize in human body and resist the gastric acid and cholate of human body. Meanwhile, the strain has better inhibitory action on Escherichia coli and can survive for 30 days at the room temperature. The strain and other lactic acid bacteria have better synergic action for growth; the strain has better combination effect with lactic acid bacteria; the product has better flavor, can be used to prepare fermented yoghurt, animal feed additives and antibacterial solution and can be widely used in the fields of other foods and biological products.

The invention provides a method for preparing a traditional Chinese medicine fruit and vegetable enzyme beverage, and relates to the food field. The method comprises the steps: mixing a fruit and vegetable mixture with rock candy according to the mass ratio of 3:(0.5-1.5), placing the mixture in a fermentation tank, and in a sealed state and under a condition of the temperature of 2-30 DEG C, fermenting for 160-200 days, to obtain a fruit and vegetable fermented liquid; mixing the fruit and vegetable fermented liquid with a traditional Chinese medicine decoction liquid, inoculating with one or two or more of lactobacillus delbrueckii subsp.bulgaricus, lactobacillus plantarum subsp.plantarum, yeast and bifidobacterium animalis, and in a sealed state and at the temperature of 35-40 DEG C, fermenting for 3-8 days, to obtain the traditional Chinese medicine fruit and vegetable enzyme beverage. The medicine and food homology and mutual harmony and complementation effects are achieved; the obtained traditional Chinese medicine fruit and vegetable enzyme beverage has the advantages of high total phenol content, high DPPH(.) scavenging rate and high SOD enzyme activity, shows strong antioxidant capacity, can improve the human body gastrointestinal health-care functions, and can be used as a daily drinking health drink.

The invention is applicable within the food and pharmaceutical industry. More specifically, it relates to a novel strain of the species Bifidobacterium animalis subsp. lactis CECT 8145, the cell components, metabolites and secreted molecules thereof, which, incorporated into food and / or pharmaceutical formulations, can be used in the treatment and / or prevention of excess weight and obesity and related diseases such as metabolic syndrome, hypertension, glycemia, inflammation, type 2 diabetes, cardiovascular diseases, hypercholesterolemia, hormonal alterations, infertility, etc.

The invention relates to a multifunctional compound health care solid beverage and a preparation method thereof. The solid beverage is composed of the following components: 50-60% of probiotics, 10-20% of prebiotics, 6-10% of water soluble cellulose, and 10-30% of fruit and vegetable enzyme powder. According to the invention, Lactobacillus acidophilus and Bifidobacterium animalis with definite intestinal flora regulation and immunity enhancing functions are taken as the main raw materials, and can regulate intestinal flora and improve body immunity from different aspects, enhance constitution, and improve the disease resistance of the body. The multifunctional compound health care solid beverage provided by the invention not only has good safety, stability and effectiveness, but also has hangover alleviating and liver protecting effects, and has good taste, thus being suitable for health care of general adults, and also being suitable for health care of the elderly or children.

The invention relates to a high-density culture method of bifidobacterium lactis V9 and a preparation method of a freeze-dried powder of the bifidobacterium lactis V9, and belongs to the field of probiotics fermentation. The bifidobacterium lactis V9 (Bifidobacterium animalis subsp.lactis V9) is acid-resistant and cholate-resistant probiotics which are separated from the intestinal tract of a healthy Mongolian child, and the collection number of the bifidobacterium lactis V9 is CGMCC No.5470. High-density fermentation of the bacteria of the bifidobacterium lactis V9 is realized under the control of an optimized culture medium and optimized fermentation conditions; the viable count in a fermentation liquor can be more than 2.0*10<10>cfu / ml, and the viable count in the freeze-dried powder of the bifidobacterium lactis prepared by using the fermentation liquor can be more than 6.0*10<11>cfu / g, and therefore, the freeze-dried powder of the bifidobacterium lactis can be applied to a probiotic leavening agent or a probiotic preparation.

The invention discloses an infant formula milk powder containing lactoferrin and probiotics, and a preparation method of the milk powder. The infant formula milk powder comprises the following raw material components: 20-40% of whole milk powder, 20-45% of demineralized whey powder, 0-18% of lactose, 0-15% of maltodextrin, 5-25% of mixed vegetable oil, 0-12% of skimmed milk powder, 0-10% of whitegranulated sugar, 1-8% of whey protein concentrate, 0-0.5% of phospholipid, 0.05-0.8% of calcium carbonate, 0.25-0.69% of a compound mineral premix, 0.06-0.07% of a compound vitamin premix, 0.1-1.8% of arachidonic acid powder (AA), 0.005-1.5% of docosahexaenoic acid (DHA), 0-0.09% of inositol, 0-0.08% of L-carnitine-L-tartrate, 0.05-0.13% of L-sodium ascorbate, 0-0.3% of tricalcium phosphate, 0.01-0.1% of lactoferrin, 0.01-0.1% of bifidobacterium animalis (Bb-12), and 0.02-0.07% of nucleotides. The infant formula milk powder prepared by the method of the invention is similar to breast milk innutrient components, meets the nutritional requirements for normal infant development, effectively improves the intestinal environment of infants, and improves the immunity of the infants.

The invention discloses a compound probiotic agent for improving immunity of dogs and reducing incidence of diarrhea as well as a preparation method and application thereof, and belongs to the field of the compound probiotic agent. The compound probiotic agent is prepared by mixing and compounding a lactobacillus plantarum KT-Lp9 microbial agent, a lactobacillus casei zhang microbial agent, a lactobacillus plantarum P-8 microbial agent, a bifidobacterium animalis subsp. lactis V9 microbial agent and a dilution carrier, wherein the quantity of viable bacteria of the four kinds of microbial agents is more than or equal to 2*10<11>CFU / g. The compound probiotic agent with different contents of viable bacteria only can be applied to 96 dogs at different ages for 60 days, so that the immunity of the test dogs can be improved, and the incidence of diarrhea and the sickness degree are reduced. Main representations are that the feed intake and growth rate of the dogs are increased, leukocyte counts, lymphocytes counts and neutrophil counts in blood are controlled, and the contents of four immunologic factors including immune globulin G, interleukin 6, interferon alpha and tumor necrosis factor alpha in the blood can be increased; and meanwhile, the content of secretory immunoglobulin A (SigA) in excrement is increased.

To provide a bacterium belonging to the genus Bifidobacterium which is excellent in a survival ability in the gastrointestinal tract, has an effect of inhibiting the cholesterol absorption in the intestinal tract, and is excellent in lipid metabolism ameliorating effects including decreasing the blood cholesterol level and the like, and shows a high survival rate after storage, and a cholesterol absorption inhibitor using the same. The invention provides a cholesterol absorption inhibitor containing, as an active ingredient, at least one microorganism selected from Bifidobacterium animalis subsp. animalis YIT 10394, Bifidobacterium animalis subsp. lactis JCM 1253, Bifidobacterium animalis subsp. lactis JCM 7117, and Bifidobacterium pseudolongum subsp. globosum.

The invention discloses compound probiotics capable of relieving ulcerative colitis, a preparation method and application thereof, and relates to the technical field of microorganisms. The compound probiotics are characterized by comprising Bifidobacterium longum BL21, Bifidobacterium animalis subsp.lactis BLa80 and Lactobacillus casei LC89. The preparation method comprises the following steps of: respectively preparing freeze-dried powder of the Bifidobacterium longum BL21, the Bifidobacterium animalis subsp.lactis BLa80 and the Lactobacillus casei LC89; and uniformly mixing the three freeze-dried powder in proportion to prepare the compound probiotics. The compound probiotics provided by the invention can prevent and / or treat ulcerative colitis, and have a great application prospect in preparation of products (such as solid beverages) for preventing and / or treating ulcerative colitis.

The invention discloses a probiotic composition for relieving anxiety or depression and an application thereof. The probiotic composition comprises prebiotics, a K-KLJ probiotic combination and functional substances. The K-KLJ probiotic composition contains at least one of lactobacillus plantarum, lactobacillus reuteri, lactobacillus casei, and lactobacillus helveticus, or also contains at least one of lactobacillus rhamnosus, lactobacillus acidophilus, bifidobacterium animalis and bifidobacterium longum. The probiotic composition of the present invention can significantly increase quantity ofbeneficial intestinal flora, improve intestinal discomfort, and reduce chronic inflammation, thereby reducing unhealthy emotion, and preventing emotional diseases such as depression and anxiety. Moreover, according to the invention, the combination of probiotic strains, the prebiotics, the probiotic strains and the functional substances have effect of significant synergistic enhancement.

The invention discloses a novel compound microbial agent used for sludge reduction treatment. The compound microbial agent consists of photosynthetic bacteria, lactic acid bacteria and saccharomycetes, and comprises bacillus subtilis, bifidobacterium animals, bifidobacterium bifidum, bifidobacterium longum, lactobacillus acidophilus, lactobacillus casei, lactobacillus delbrueckii, lactobacillus fermentium, lactobacillus plantarum, lactococcus lactis, rhodopseudomonas palustris, streptococcus thermophilus and saccharomyces cerevisiae which are 13 different microorganisms in total. The compound microbial agent can reduce BOD (biochemical oxygen demand), COD (chemical oxygen demand) and TSS (total suspended solids) to expected values, effectively reduces sludge deposit in a treatment plant, and reduces corrosion on equipment to lower maintenance cost; and besides, bacteria can decompose an organic compound and can generate byproducts beneficial to environment.

Provided is fragrant pig derived cholesterol-assimilating and oxygen-resistant bifidobacterium BZll. The fragrant pig derived cholesterol-assimilating and oxygen-resistant bifidobacterium BZll is Bifidobacterium animalis subsp.Lactis, the pure culture of the fragrant pig derived cholesterol-assimilating and oxygen-resistant bifidobacterium BZll is preserved at the China General Micro-biological Culture Collection Center (CGMCC), China Microbial Culture Preservation Management Committee, the address is Institute of Microbiology, Institution No.3 China Academy of Science, Western Beichen Road No.1 in Chaoyang District of Beijing in China, the postal code is 100101, the preservation number is CGMCC NO.10224, and the Bifidobacterium animalis subsp.Lactis BZll is called for short. The Bifidobacterium animalis subsp.Lactis BZll is high in cholesterol-assimilating capacity, acid resistance and cholate resistance, good in oxygen resisting performance, has probiotic property and can serve as probiotics to be added into a fermentative milk product to produce a functional food, bifidobacterium culture resources are enriched, and development of bifidobacterium health-care products is facilitated.

The invention provides composite probiotic lactobacillus powder as well as a preparation method and application thereof. The composite probiotic lactobacillus powder is prepared by compounding lactobacillus casei Zhang powder, bifidobacterium animalis V9 powder, lactobacillus plantarum P-8 powder, lactobacillus plantarum C2 powder, prebiotics and fruit and vegetable powder. The composite probioticlactobacillus powder has the remarkable protective effect on irritable bowel syndrome, oral infection and nasal infection, has the remarkable prevention effect on occurrence of upper respiratory infection, can improve gastrointestinal symptoms and adjust intestinal flora, and can improve the immunity of the organism.

The invention provides a probiotic composition and a preparation method and applications thereof, and belongs to the technical field of health-care foods. The probiotic composition comprises probiotics and prebiotics. The probiotics comprise lactobacillus acidophilus NCFM, lactobacillus rhamnosus HN001, lactic acid bacteria composite powder GI, lactic acid bacteria composite powder OH, bifidobacterium animalis B94, bifidobacterium bifidum R0071, lactobacillus casei R0215, live bacillus coagulans GBI30,6086 and lactobacillus rhamnosus GG. The prebiotics include fructo-oligosaccharides, resistant dextrins and lactitol. The mass ratio of the probiotics to the prebiotics is (300-350):(1300-1400). The total viable bacteria concentration of the probiotics in the probiotics composition is more than or equal to 9.0x10<9> CFU / g. The probiotic composition provided by the invention can obviously improve sleep quality, and significantly relieve anxiety and depression.

The invention discloses a micro-ecological composition for improving constipation by targeting intestinal flora and a preparation of the micro-ecological composition. The micro-ecological compositioncomprises probiotics, prebiotics and medicinal and edible traditional Chinese medicines, wherein the probiotics are selected from at least one of bifidobacterium animalis, bifidobacterium adolescentis, bifidobacterium longum, bifidobacterium breve, lactobacillus rhamnosus, lactobacillus acidophilus, lactobacillus helveticus, lactobacillus plantarum, lactobacillus reuteri, lactobacillus paracasei and bacillus coagulans; the prebiotics are selected from at least one of stachyose, fructo-oligosaccharide, isomalto-oligosaccharide, galacto-oligosaccharide, inulin, resistant dextrin and xylooligosaccharide; and the medicinal and edible traditional Chinese medicines are selected from at least one of semen sesami nigri, semen cassiae, fructus cannabis, honey, semen lablab album, semen coicis, poria cocos and lotus leaves. The micro-ecological composition can effectively regulate intestinal tract micro-ecology in a targeted mode, and finally the purpose of improving constipation is achieved.

The invention discloses mixed probiotic tablets and a low-temperature coating preparation method thereof and belongs to the field of probiotic tablets. The mixed probiotic tablets are prepared from 2-7 parts of a lactobacillus acidophilus KT-A1 agent, 2-7 parts of a lactobacillus casei Zhang agent, 2-7 parts of a bifidobacterium animalis subsp. lactis V9 agent and 2-7 parts of a lactobacillus plantarum P-8 agent with a low-temperature coating technology. According to the probiotic tablets prepared with the method, bacterium loss of probiotics in a tablet preparation process is avoided, after the tablets are stored for 5 months at the temperature of 37 DEG C, the total viable count of probiotics in the product keeps not lower than 5*10<9> CFU / g; furthermore, storage stability of the probiotics in the shelf life of the product is greatly improved, weight of each tablet is 0.7-0.9 g, the hardness reaches 7 N / cm<2> or higher, the surface is smooth, and the phenomenon of powder falling is avoided. Besides, the mixed probiotic tablets have excellent resistance to gastrointestinal digestive juice, improve capacity of intestinal microbial community structure of a human body and have a regulating function for body immunity.

The invention provides a granulation-resisting lactic acid bacterium preparation and a preparation method thereof. The granulation-resisting lactic acid bacterium preparation comprises lactic acid bacterium; the lactic acid bacterium is one or a combination of more of enterococcus faecalis, enterococcus faecium, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus lactis, lactobacillus buchneri, lactobacillus casei and bifidobacterium animalis; a viable count of the lactic acid bacterium reaches 1.0*10<10> to 1.0*10<11>CFU / g. According to the preparation method of the lactic acidbacterium preparation, provided by the invention, the tolerance of thalli is improved and the loss of bacterium activity in a processing process is avoided.

The invention belongs to the technical field of food and health care products, and particularly relates to a quintuplet probiotic composition for improving intestinal tracts. The quintuplet probioticcomposition comprises the following components in parts by weight: 60-65 parts of polyisomaltose, 25-30 parts of maltodextrin, 15-20 parts of erythritol, 10-12 parts of galactooligosaccharide and 11-25 parts of probiotic, wherein the probiotic comprises lactobacillus rhamnosus R0011, lactobacillus helveticus R0052, lactobacillus rhamnosus GG, animal bifidobacterium B94 and bifidobacterium longum R0175. At the same time, the invention provides a composite solid beverage prepared from the quintuplet probiotic composition. Through a scientific strain ratio, gastrointestinal tracts are promoted toabsorb an effective quantity of viable bacteria; intestinal florae are adjusted; uncomfortable symptoms of the gastrointestinal tracts, such as various uncomfortable symptoms of the gastrointestinaltracts after flora disequilibrium due to bacterial infection and antibiotic related diarrhea, are improved; an intestinal environment is adjusted, so that the immunity is boosted; an immunoreaction ofan allergic disease is adjusted fundamentally; a constitution environment of females can also be improved; and bacterial vaginitis is effectively prevented and treated.

The invention discloses a preparation method of xylooligosaccharide with low DP (degree of polymerization). The preparation method is characterized by comprising steps as follows: (1) wood fiber biomass is taken as a raw material and subjected to diluted acid / diluted base / hot water pretreatment, a liquid is filtered, a solid phase is treated in a high-temperature degrading or steam explosion pretreatment manner, and the wood fiber biomass is cooled for later use; (2) xylanase is added to a pretreatment solution in step (1) for an enzymatic hydrolysis reaction; (3) an enzymatic hydrolysis solution is treated through enzyme deactivation, purification, concentration and drying, and xylooligosaccharide with low DP is prepared. The DP of finally obtained xylooligosaccharide is low by reasonably optimizing each process step, and xylobiose, xylotriose and xylotetraose are taken as main components, so that the functionality of xylooligosaccharide as a bifidus factor is enhanced. Tests verify that prepared xylooligosaccharide has a good proliferative effect on bifidobacterium animalis and lactobacillus casei. The process is simplified, the product quality is improved, and xylooligosaccharide has good application prospect.

The invention discloses a method for preparing large-headed atractylodes rhizome polysaccharide and application. The method for preparing the large-headed atractylodes rhizome polysaccharide comprises the following steps of: 1) soaking large-headed atractylodes rhizomes into water, then decocting the rhizomes, collecting filtrate, and concentrating the filtrate to obtain large-headed atractylodesrhizome extract; 2) adding ethanol into the extract, standing the extract at the temperature of 4 DEG C, centrifuging the extract and collecting sediment, dissolving the sediment, removing the ethanol, small molecular sugar, protein and salt by dialysis, and drying the extract to obtain coarse large-headed atractylodes rhizome polysaccharide; and 3) dissolving the large-headed atractylodes rhizome polysaccharide, then adding Saveg liquid in the volume which is 2 times that of the solution, mixing and shaking the solution uniformly, centrifuging the solution and collecting supernate, then removing chloroform and n-butyl alcohol by dialysis from water, and drying the supernate to obtain the large-headed atractylodes rhizome polysaccharide without containing the protein. Proved by experiments, the large-headed atractylodes rhizome polysaccharide can promote proliferation of probiotics of infants, youth, animal bifidobacterium, plant lactobacillus and the like in vitro, can be used as probiotics for production, has the effect of regulating intestinal flora balance, and can be used as novel functional probiotics for development.

The invention belongs to the field of microbial fermentation, and especially relates to a fermentation metabolite having an effect of protecting skins, and a preparation method and applications thereof. The product is prepared by taking lactobacillus plantarum, lactobacillus casei, lactobacillus lactentis, bifidobacterium animalis and lactobacillus rhamnosus as fermentation strains and taking sucrose, seaweed meal, soybean meal and milk powder as fermentation raw materials through mixing and fermentation. The product contains specific fermentation metabolites, such as malonylgenistin, genistein, hyaluronic acid, irone, Preaustinoid A and daidzein, which are helpful for the enhancement of a skin protection effect; and tartaric acid, malic acid, succinic acid, salicylic acid, vanillic acid, phenylpropionic acid and other organic acid generated by fermentation can control pathogenic bacteria and spoilage microbial flora, so that skin flora balance can be maintained, and a natural antiseptic effect can be achieved. Efficacy tests show that the product has the efficacy of removing wrinkles, increasing skin elasticity, resisting inflammation and repairing skin barriers, and is significant in effect.

The invention discloses bifidobacterium animalis NX-6 and application thereof in preparation of lipid-lowering and weight-losing medicines, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium animalis NX-6 disclosed by the invention is CGMCC (China General Microbiological Culture Collection Center) No. 20114. The uninactivated and inactivated fermentation supernate, bacterial suspension and cell disrupted supernate of novel bifidobacterium animalis NX-6 show good effects of slowing down weight and body length increase, improving body mass index(BMI) and reducing fat area percentage on zebrafish, and have a potential weight losing effect; triglyceride (TG) and total cholesterol (TC) in a zebrafish hyperlipidemia model body can be obviously reduced, and a good hypolipidemic effect is shown. The novel bifidobacterium animalis NX-6 disclosed by the invention has a huge potential application prospect in the aspect of preparing medicines fortreating and / or preventing obesity and hyperlipidemia.

The invention discloses a bifidobacterium animalis and application thereof in preparing a bifidobacterium fermented beverage. The bifidobacterium animalis is bifidobacterium animalis 01, and has the preservation number of CGMCC 1353. The bifidobacterium animalis 01 with the preservation number of CGMCC 1353 can be used for preparing the bifidobacterium fermented beverage. The prepared yacon bifidobacterium fermented beverage has mild color (as shown in figure 1), good mouth feel, good flavor and longer shelf life, and is a health beverage with a good health-care effect.

The application provides compound probiotics powder for treating irritable bowel syndrome (IBS). The compound probiotics powder is prepared from lactobacillus casei Zhang, bifidobacterium animalis subsp. lactis V9 and lactobacillus plantarum P-8; the compound probiotics powder is obtained through optimizing, compounding and combining nutrient substances with different properties; the compound probiotics powder can regulate intestinal flora, effectively treats the IBS, can obviously improve symptoms, and reduces inflammatory responses, thereby solving the problems that existing compound probiotics lactobacillus powder is single in flora composition, low in viable count, and poor in probiotics safety, and is lacking in probiotics preparations which effectively treat the IBS; the compound probiotics powder has wide market prospects.

The invention discloses Bifidobacterium animalis with a bowel relaxing function and application and a preparation of the Bifidobacterium animalis. According to the Bifidobacterium animalis, Bifidobacterium lactis BB-11 is separated from an intestinal content of healthy and long-lived elderly people in Bama, Guangxi, the strain is carried on a spacecraft, finally, a Bifidobacterium animalis MN-Gupwith significantly improved oxygen resistance or significantly enhanced oxygen resisting capacity is screened by space mutagenesis, and evaluation of constipation model mice proves that the strain hasthe good bowel relaxing function and has broad application prospects in bowel relaxing drugs, health foods and foods.

The invention provides a repairing and soothing skin care product containing a postbiotic component and a preparation method thereof. The repairing and soothing skin care product comprises the following components in percentage by mass: 1-5% of the postbiotic component, 1-8% of grease, 3-5% of a skin conditioner, 9-15% of a humectant, 0.5-8% of a surfactant, 0.6-1.2% of a thickening agent and the balance being deionized water. The postbiotic component comprises an antibacterial substance and an active metabolite, has the effects of reconstructing skin cells, improving elastin and updating metabolism of a corium layer, and has an effect of promoting proliferation of cuticle cells, and the prepared skin care product can enhance skin elasticity and has obvious skin soothing and repairing effects. According to the invention, the postbiotic component is a mixed solution obtained by fermenting a variety of strains such as lactobacillus plantarum, lactobacillus casei, bifidobacterium lactis, bifidobacterium animalis and lactobacillus rhamnosus; compared with a postbiotic component obtained by single strain fermentation, the effect of eliminating wrinkles and enhancing skin elasticity is better, and the multi-dimensional skin problem can be solved.