79results about How to "Easy to implement industrial production" patented technology

The invention discloses a new chemical synthesizing method of yipisidin, which comprises the following steps: ammonifying 6-chloromethyl-11-dihyrogen-dibenz [b,e] aza to generate 6-aminomethyl-11-dihydrogen-dibenz [b,e] aza; reducing the 6-aminomethyl-11-dihydrogen-dibenz [b,e] aza into 6-aminomethyl-6,11-dihydrogen-5H-dibenz [b,e] aza; generating the product through cyanogen bromide to loop. The invention simplifies the making method with little by-product, which improves the receiving rate by 69% with high purity (HPLC. 99. 0%) for industrial manufacturing.

The invention provides a preparation method for preserved meat, relating to the preparation method for healthcare food, which is characterized in that the food is prepared by the steps of selecting materials, washing, crushing, boiling, pickling with ingredients, loading into a die, slicing, roasting, dehydrating, packing and sterilizing. The preparation method for the preserved meat has the beneficial effects that, the food is a pure natural green food, which has general equilibrium nutritionally; the preparation agrees with the nation-specified sanitary standards; the food fully utilizes the raw material, which is easy for industrial production; and the preserved meat prepared by the method has perfect natural muscle fiber, favorable texture and taste, which is not only suitable for the life rhythm of modern people, but also leads to better absorption of human body.

The invention provides rice-shaped precipitation calcium carbonate, a preparation method and the application thereof. The preparation method comprises the steps that: (1) crystal control agent is added into calcium hydroxide aqueous suspension to obtain mixture; (2) the mixture of the first step is communicated with carbon dioxide for carbonization reaction until the pH value of the mixture reaches 6.5-8.5 and the rice-shape calcium carbonate is collected from the reaction products; the crystal control agent is soluble carbonate. The rice-shape calcium carbonate of the invention has moderate length diameter ratio, which is easier to be maintained in paper fiber than ordinary light calcium carbonate, and increases the smoothness of the paper at the same time; furthermore, the invention not only preserves the printing quality of the paper, but also reduces the consumption of filler and increases retention rate, meanwhile, the manufactured paper has superior characteristics of high stiffness and high smoothness and has no problems of alkali recycling and discharging, being easy for implementing industrialized production.

The invention provides a method for preparing a 16a-hydroxyl prednisolone product. The method comprises the steps: firstly, subjecting 17a-deshydroxy prednisolone acetate, which serves as a starting raw material, and organic peroxy acid to an epoxidation reaction at 16,17 sites in a first organic solvent, so as to prepare epoxide; subjecting the epoxide and glacial acetic acid to a ring-opening reaction under the catalysis of an acid catalyst in a second organic solvent, so as to prepare 16a,21-diacetoxyl prednisolone; then, dissolving the 16a,21-diacetoxyl prednisolone in a third organic solvent, and hydrolyzing acetate of two positions under the catalysis of a solid-phase alkali catalyst, so as to prepare 16a-hydroxyl prednisolone; finally, subjecting the crude 16a-hydroxyl prednisoloneobtained through solid-phase alkali-catalyzed hydrolysis to heated refluxing, decoloring and recrystallization by low carbon alcohols of C4 or less, thereby obtaining the 16a-hydroxyl prednisolone product. The 16a-hydroxyl prednisolone is prepared by the efficient, environment-friendly and cheap method.

The invention discloses a process for extracting organic acid from fermentation liquor through film method, which consists of the steps of fermentation liquor preparation, ultrafiltration, nano filtration, deionization and concentration. The invention has the advantages of simple operational process, low cost of production, high yield, and complete de-sugaring.

The invention provides an instant pork skin crystal, relating to a preparation method for healthcare food, which is characterized in that the food is prepared by the steps of selecting materials, washing, undergoing acid and alkali treatment, boiling, chopping, puffing, drying, preparing into product, packing and sterilizing. The instant pork skin crystal has the beneficial effect that, the method for preparing the edible pork skin crystal has the advantages of high temperature and long term infusion saving, simple technology, time and labor saving, full utilization of large amount of pork skin resources, and industrial treatment. The product has nutritionally general equilibrium, full utilization of raw materials and easy industrial production, and the preparation of which agrees with the nation-specified sanitary standards. The pork skin crystal prepared by the method has perfect natural muscle fiber, favorable texture and taste, which is not only suitable for the life rhythm of modern people, but also leads to better absorption of human body.

The invention relates to the field of industrial casting, in particular to a moulding sand additive suitable for an iron casting piece. The moulding sand additive suitable for the iron casting piece is prepared from mixing the following raw materials in percentage by mass: 20 to 40 percent of aluminosilicate powder, 10 to 19 percent of graphite powder, and 50 to 70 percent of bentonite, wherein the aluminosilicate powder is prepared from mixing the following raw materials in percentage by mass: 55 to 80 percent of SiO2, 7 to 40 percent of Al2O3, 0.5 to 6 percent of Na2O, 0.5 to 6 percent of K2O and 0.5 to 9 percent of Fe2O3. The additive is prepared from inorganic composite materials, is incombustible so as not to produce toxic and hazardous waste gas during a production process, and is green and environmental-friendly. The moulding sand additive mainly replaces pulverized coal in wet type clay sand, has excellent clay sand resistance, and is used for the iron casting piece, so that the wettability of a casting mould and a metal liquid is reduced, the casting piece cannot stick sand, and the occurrence of the defects such as scab of the casting piece is reduced.

The invention discloses a tin dioxide/polypyrrole nanocomposite. A tin tetrachloride solution and urea are taken as raw materials, and nano tin dioxide is prepared through a hydrothermal method in a microemulsion system including CTAB (cegtyl trimethyl ammonium bromide), n-pentanol and n-hexane; and then in the microemulsion system, ferric trichloride is taken as an oxidizing agent, and the material is prepared through microemulsionin situ polymerization to a pyrrole monomer. According to the composite material, nano tin dioxide is dispersed in loose conductive polypyrrole matrix, so that electrical contact between tin dioxide particles can be guaranteed effectively, and the nanocomposite is enabled to combine advantages of polypyrrole and tin dioxide, is expected to be an excellent Lithium-ion battery material, and is widely applied to the fields of micro-electronics, sensing, energy and the like. Meanwhile, the preparation method combines the advantages of the hydrothermal method and the microemulsion method, and has the advantages of easily obtained synthesis raw materials, simple synthesis and low cost.

The invention discloses a spherical shell laminar magneto-electric composite material structure and a manufacturing method, and relates to the design and manufacture method of an isotropic magneto-electric effect laminar magneto-electric composite material structure. The method comprises the following steps: hemispherical shell piezoelectric ceramic is achieved through compression molding and sintering, after the high-temperature polarizing is performed, metallizing is performed by adopting the chemical plating method, two metallized piezoelectric ceramic hemispherical shells are bonded into a complete piezoelectric ceramic hemispherical shell through the strong glue, and then the shell is laid in the prepared electroplating solution to be electroplated till a magnetic layer with the required thickness is electroplated, thereby the spherical shell laminar magneto-electric composite material is achieved. Compared with the prior simple laminar composite material, such as a flat plate, because the dimensions of the structure in the three-dimensional direction are identical, the magneto-electric performances of the structure in all directions are identical, and by adopting the isotropic magneto-electric performance, the spherical shell laminar magneto-electric composite material can be applied to the magnetic field detection in the unknown directions.

The invention belongs to the field of pharmaceutical synthesis, and provides a dabigatran etexilate mesylate preparation method, which comprises: carrying out a ring closure reaction on 3-[(3-amino-4-methylaminobenzoyl)(pyridine-2-yl)amino] ethyl propionate and chloroacetic anhydride to generate N-[[2-(chloromethyl)-1-methyl-1H-benzimidazole-5-yl]carbonyl]-N-2-pyridyl-beta-alanine ethyl ester, carrying out a condensation reaction on the N-[[2-(chloromethyl)-1-methyl-1H-benzimidazole-5-yl]carbonyl]-N-2-pyridyl-beta-alanine ethyl ester and 4-aminobenzamidine dihydrochloride to obtain 3-({2-[(4-amidino-phenylimino)-methylene]-1-methylene-1H-benzimidazole-5-carbonyl}-pyridine-2-imine)-ethyl propionate, carrying out ester forming on the 3-({2-[(4-amidino-phenylimino)-methylene]-1-methylene-1H-benzimidazole-5-carbonyl}-pyridine-2-imine)-ethyl propionate and hexyl chloroformate to obtain dabigatran etexilate, and carrying out salt forming on the dabigatran etexilate and methanesulfonic acid to obtain dabigatran etexilate mesylate. According to the present invention, the route of the method has characteristics of high yield, mild condition and convenient intermediate purification, and meets the requirements of industrial production.

A method for manufacturing a bimetallic composite strip, comprising the steps of surface pretreatment, rolling composite, heat treatment of the composite strip, and the like. This method also adds surface initial adsorption after surface pretreatment, and nitrogen is sprayed on the clean metal surface to form a nitrogen adsorption film on the metal surface. The rolling compounding of this method adopts rapid electric heating and non-isothermal rolling compounding. This method has the advantages of simple process, convenient operation, significantly reduced cost, improved composite strength, favorable interface bonding, and improved reprocessing performance of the composite plate.

The invention discloses a preparation method of flurogestone acetate. The preparation method comprises the following steps: using 9a-cortisone bifluoride as a raw material, dissolving 9a-cortisone bifluoride into an organic solvent, and reacting with acyl chloride under the existence of an acid-binding agent to obtain a 9a-cortisone bifluoride-21-O-ester; then reacting the ester with sodium iodide and a sulfur-containing reducing agent in the organic solvent for deesterification, and synthesizing flugestone; and finally reacting the flugestone with acetylchloride or acetic anhydride in the organic solvent, and synthesizing flurogestone acetate. According to the preparation method, 9a-cortisone bifluoride is used as the raw material, flurogestone acetate is synthesized through three-step reaction of 21-site esterification, then reduction and de-esterification and finally 17-site ethyl esterification, and compared with a traditional synthetic method for using a mold removal object acquired through diosgenin processing as a raw material, the preparation method has the advantages such as wide raw material source, short synthetic route, simple, convenient and environmentally-friendly process, few invested equipment and high product yield, and the production cost in the method is reduced by 25% to 30% as compared with a traditional method; and a solvent used in the production can be recycled and circularly used, and is easy for industrial production.

The invention relates to the technical field of packaging materials for photovoltaic modules, and provides a high-strength hydrophobic high-reliability packaging adhesive film. The high-strength hydrophobic high-reliability packaging adhesive film comprises an EVA adhesive film layer, a high-strength hydrophobic layer, a water absorption bonding layer and a polyolefin adhesive film layer which are sequentially arranged from top to bottom. Transverse and longitudinal grooves are formed in the upper surface of the EVA adhesive film layer and the lower surface of the polyolefin adhesive film layer and form #-shaped pattern surfaces; a plurality of regular first arc structures are arranged on the lower surface of the high-strength hydrophobic layer; and a second arc structure matched with the first arc structure is arranged on the upper surface of the water absorption bonding layer. The invention further provides a preparation method of the high-strength hydrophobic high-reliability packaging adhesive film. The front surfaces of the composite high-strength hydrophobic layer and the water absorption bonding layer functional film are compounded with the transparent EVA adhesive film, the back surfaces are compounded with a transparent polyolefin film, and then the upper surface and the lower surface are subjected to #-shaped embossing and rolling. The packaging adhesive film is good in water blocking effect and high in tensile strength, the mechanical performance of a packaging assembly can be effectively improved, and the lightweight design of the packaging assembly is promoted.

Disclosed is a method for preparing a dehydrogenated intermediate product for aclomethasone dipropionate. The method comprises the steps that with 16a-methyl pihydrocortisone as a raw material, a crude dehydrogenated intermediate product for aclomethasone dipropionate is synthesized through a six-step reaction of 21-site propionic acid esterification, 7,11-site double-oxidation into diketone, 17-site propionic acid esterification, 3-site enolization etherification protection, 7,11-site diketone reduction and acid hydrolysis deprotection and 1-site DDQ dehydrogenation, then the dehydrogenated intermediate product for aclomethasone dipropionate is obtained through refining. By means of the method, with 16a-methyl pihydrocortisone as the raw material, the dehydrogenated intermediate product for aclomethasone dipropionate is synthesized through the six-step reaction; the process has the advantages of being short in synthesis route, economical, environmentally friendly, simple in productionoperation, high in product yield and the like; a solvent used in production can be recycled and applied, and industrial production is easy to implement.