The invention discloses high-stability water-based ink, and particularly relates to the technical field of ink. Deionized water is added into a dispersion kettle, the mixture is heated to 80 DEG C, then acrylic resin, a defoaming agent and isopropanol are added and stirred for 10 min to be uniformly dispersed, finally, a mixed solution of ammonia water and ethanolamine is added, the mixture is stirred until the resin is dissolved, the proportion of the ammonia water is adjusted, after mixing is completed, phthalocyanine blue, filler, a dispersing agent, a thickening agent and an anti-corrosion and anti-mildew agent are added into the solution to be dispersed in a high-speed dispersion machine in advance, the stirring speed is 900-1100 rpm, the stirring time is 1-2 h, then standing is conducted to the normal temperature, then grinding is conducted, the fineness is detected, the water-based ink can effectively overcome the defects of low drying speed, poor water resistance and low glossiness of the current water-based ink for flexible board printing, and the raw materials adopted in the preparation process of the water-based ink are cheap and easy to obtain, the production process is simple, the ink stability is high, and the water-based ink has very high popularization value in the field of the water-based ink for flexible board printing.