The invention relates to esthetic gouache color containing nano-pigments and process for preparation, in particular belonging to the technical field of paints. The invention is characterized in that natural peach glue and acacia gum are taken to be added into formula distilled water to be heated, mixed, melted and made into adhesive glue solution. After being added with nano graining paste and pigment powder which are uniformly mixed with the adhesive glue solution, the adhesive glue solution is further added with lithopone, glycerol, sodium benzoate, and phenoxetol to be uniformly mixed, the mixture forms coarse paste which is added into a hopper of a three-roll grinder to be ground, and the ground slurry flows into a storage barrel, thereby achieving finished goods. The invention is powerful and bright in color, good in dyeing force and good in chroma, not only has good usability and bright color, but also has perfect weatherability and chemical durability, which meets the high demands of artists for the gouache color for art purposes.