5 results about "Chloranolol" patented technology

The invention discloses a preparation method of high-purity 2-fluoroethanol, and particularly relates to the technical field of preparation of 2-fluoroethanol, which comprises the following steps: S1, in a dual-catalyst system consisting of a phase transfer catalyst and a Lewis acid catalyst and an organic solvent, carrying out fluoridation reaction on 2-chloroethanol and anhydrous potassium fluoride at 60-120 DEG C for 2-10 hours to obtain 2-chloroethanol; and S2, sequentially carrying out integrated purification of filtration, reduced pressure distillation, adsorption treatment and rectification on the reaction mixture. According to the invention, through synergistic activation and mass transfer of double catalysts, the reaction rate and selectivity are significantly improved, the water segregator is utilized to remove reaction water to push equilibrium movement, the conversion rate is improved, and water and impurities are systematically removed by virtue of composite adsorption and precise rectification of molecular sieves and activated carbon, so that high-quality 2-fluoroethanol with high purity and low moisture is finally obtained. The whole preparation process is mild in condition, high in yield, good in safety and suitable for industrial production.

The invention belongs to the technical field of organic synthesis, and particularly relates to a production and preparation method of 2-chloroethoxyethanol. In the reaction process, chloroethanol is precooled to 0 DEG C, the temperature in the reaction kettle is controlled to be 3-8 DEG C, ethylene oxide is introduced in three stages, the pressure is kept to be 0.3-0.6 MPa, the temperature is low, and ethylene oxide is introduced in stages, so that the local concentration of ethylene oxide can be prevented from being too high, side reactions are reduced, and the reaction selectivity is improved. The used composite catalyst has sufficient active sites and is beneficial to diffusion of reactants and products, the supported phosphotungstic acid is used as a strong acid catalyst and can effectively activate epoxy bonds of ethylene oxide and promote nucleophilic addition reaction of ethylene oxide and chloroethanol, and the supported metal elements are capable of effectively activating the epoxy bonds of ethylene oxide and promoting the nucleophilic addition reaction of ethylene oxide and chloroethanol by adjusting the electronic properties of the catalyst. The catalytic activity and selectivity are improved, and the reaction is promoted together with phosphotungstic acid.

The application relates to the technical field of organic synthesis, and particularly discloses a method for preparing 2-chloroethyloxy ethanol through combined catalysis, which comprises the following steps: under the catalysis of a main catalyst and an auxiliary catalyst, 2-chloroethanol and ethylene oxide are subjected to an alkylation reaction; after the alkylation reaction is completed, the alkylation reaction liquid is heated and desoluted to obtain a concentrated liquid, and 2-chloroethanol is recovered; and the concentrated liquid is distilled to obtain the target product 2-chloroethyloxy ethanol. The main catalyst and the auxiliary catalyst are combined to catalyze, the addition amount of boron trifluoride diethyl ether is greatly reduced, the generation amount of three wastes is reduced, the catalytic reaction rate is controllable, the side reaction is less, and the product has high purity.

The utility model provides a 2-chloroethanol wastewater pretreatment device which comprises a pretreatment tank, a supporting block, a driving motor, a water inlet pipe, a water drainage pipe, a connecting pipe, a supportable turning and stirring spraying disc structure, a sprayable adding storage tank structure and a cleanable circulating auxiliary box structure, supporting blocks are respectively fixed at four corners of the bottom end of the pretreatment tank through bolts; a driving motor is fixed in the middle of the upper end of the pretreatment tank through a bolt. Through the arrangement of the rotating pipe, the H-shaped fixed pipe, the spraying disc, the water supply pipe, the adjusting pipe, the spraying head and the spiral plate, waste water can be turned in the rotating process of the spiral plate in the pretreatment process, water is supplied through the water supply pipe, then spraying is performed through the spraying head, the purpose of foam spraying elimination is achieved, and the waste water treatment efficiency is improved. Meanwhile, by adjusting a valve arranged in the middle of the upper end of the adjusting pipe, the pressure in the spraying process can be conveniently adjusted.

This application discloses a method for targeted modification to improve the activity of halohydrin dehalogenase, belonging to the field of bioengineering technology. The halohydrin dehalogenase mutant obtained by this application is produced by single-point mutation or combination mutation of alanine at position 60 and histidine at position 179 in the sequence shown in SEQ ID NO.1. Compared with the wild-type halohydrin dehalogenase, the mutant obtained in this application shows significantly improved enzyme activity and dehalogenation efficiency in the catalytic preparation of 1-chloro-2-propanol and 2-chloro-1-ethanol. The mutant enzyme activity is increased by 1.78 times, and the dehalogenation efficiency is increased by 77.8%, showing good prospects for industrial application.