The invention discloses a preparation method of a Cu-Cr-Zr wear-resistant alloy wire. The method comprises the following steps: S1, powder metallurgy: firstly, preparing a Cu-Cr alloy or Cr-Zr alloy or Cu-Cr-Zr alloy or a combined alloy thereof into powder with the diameter of 50-300 [mu]m, then, carrying out dry pressing or sintering on the powder to prepare a block material, and finally, crushing the block material into particles with the size of 1-10 mm for later use; and S2, smelting: firstly, smelting 50-90% of cast ingot raw materials into an alloy solution under a vacuum condition at the smelting temperature of 1,200to 1,370 DEG C, keeping the vacuum degree at 10<-2> to 10<-5>MPa, keeping the temperature at 1,200 to 1,300 DEG C after complete smelting, and refining to remove impurities and gas. According to the process, the wear-resistant alloy wire with higher tensile strength, better wear resistance, better corrosion resistance and higher conductivity can be prepared, it can be seen from the microscopic structure of the product that the second phase is distributed in a dispersed mode, and the wear resistance and the mechanical property of the material are well improved.