The invention discloses a micro-needle made of a strong hydrophilic base material, and particularly relates to a micro-needle and a
drug-loaded micro-needle which are prepared by using a composition of
polyvinyl alcohol and a micromolecular
polyhydroxy compound as a base material and have a strong hydrophilic surface, and an application of the micro-needle and the
drug-loaded micro-needle in
disease treatment. The polyhydroxy high-molecular substance
polyvinyl alcohol is compatible with the micromolecular
polyhydroxy compound, the microneedle with the strong hydrophilic surface can be obtained, a
medicine can be strongly adsorbed as long as the microneedle is in contact with the
medicine, the microneedle is unlikely to fall off, a technology is simple,
mass production is easy, a
drug loading capacity is obviously increased,
medicine use efficiency is high, blank microneedle preparation and medicine loading are carried out in different stages, a high temperature is avoided in a drug loading stage, and therefore, the drug-loaded microneedle can be effectively applied to drug loading and
drug release for treating diseases and is easy in
mass production. The microneedle base material composition, the blank microneedle prepared from the microneedle base material composition and application of the blank microneedle to drug loading can keep the inherent surface strong hydrophilic polarity of
polyvinyl alcohol, so that the drug loading capacity of wrapped drug loading and a penetration amount of drugs entering the body are obviously improved.