The invention discloses a nano-soft-sensitive detoxifying cream. The nano-soft-sensitive detoxifying cream comprises water, a hamamelis virginiana extract, hydrogenated jojoba oil, 1,2-butanediol, squalane, a rose extract, glyceryl stearate, avocado oil, glycerol, stearyl alcohol, 1,2-pentanediol, an aloe extract, polyglutamic acid, beta-glucan, nicotinamide, a chamomilla recutita flower extract, an European golden sunflower extract, a paeonia albiflora root extract, a lonicera japonica extract, an European dandelion stem/root extract, a herba violae extract, aloe barbadensis leaf juice, polysorbate-60, piperitol, polyacrylamide, ferric oxide class, titanium dioxide, aloe vera powder, 1,2-hexanediol, ascorbic acid, xanthan gum, ceramide, tripeptide-3, hyaluronic acid, a bitter root extract and a hippophae rhamnoides extract. The nano-soft-sensitive detoxifying cream can give long-standing moisturizing performance and is anti-aging, anti-oxidative and anti-radiation, and free radical is removed; toxin is removed, and blood microcirculation is improved.