The invention is a feed additive containing microbe and bio-enzyme, and its character: it is composed of beneficial bacteria, functional enzyme, mineral trace elements, and feed carrier. It has multielements to cooperate with one another, and thus it has good synthetic effect, and its microbes are obtained by solid fermentation, and thus the device investment is low, the low-temperature drying effectively assures the nutrient constituents, and the variety and activity of the microbes and bio-enzymes from not being lost, and simultaneously reduces enzyme extraction procedures, and extremely reduces the production cost; the product meets the dispersion of various effective constituents in the raw materials on the carrier as far as possible, so as to fully use them to achieve the best effect. It uses the addition of beneficial bacteria to regulate the balance of bacteria crowd in the stomach intestine of the domestic animal and fowl, improves the micro-ecological environment, and makes the domestic animal and fowl keep naturally healthy physique; inhibits and prevents the occurrence of the bacterial diseases, such as Escherichia coli disease, salmonella disease, etc, reducing antibiotic usage, reducing therapeutic expenses and improving the productivity of the animal.