The invention relates to a production method of
erythromycin thiocyanate, which is characterized in that
erythromycin filtrate is treated by bleaching subtraction resin and condensed to 18000u / ml-20000u / ml by a
nanofiltration membrane with molecular weight of 600, strong
ammonia water is introduced when the condensed liquid is condensed and heated to 55DEG C to 56 DEG C, the PH value is controlled from 9.8 to 10.0, the introducing time of
ammonia is 30 minutes to 45 minutes,
erythromycin alkali can be obtained by extracting and filtering a crystalline liquid immediately, and then the erythromycin alkali is dissolved to be a solution of 30000u / ml to 35000u / ml by
butyl acetate,
crystallization is carried out according to a method of
solvent extraction
crystallization, and then the
thiocyanate erythromycin can be obtained by
centrifugal separation. The production method of the
erythromycin thiocyanate uses the method of water-phase crystallizing the erythromycin and then transferring salts by the
solvent, the product quality is good, the unit consumption of the
solvent is low, the yield is similar to the solvent method, moreover, the production
wastewater realizes removing
contamination and shunt, is easy to treat, and has good environmental benefit.