47 results about "Oxalate salt" patented technology

A preparation method of N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate enzyme belongs to the field of medical intermediates, and comprises the following steps: step 1, preparing a buffer solution of a compound enzyme preparation; step 2, adding (2S)-2-benzyloxy-3-pentanone into a solvent A, and then adding a buffer solution of the compound enzyme preparation for reaction; 3, filtering, and carrying out an activation reaction on the filtrate; 4, filtering, removing the solvent, adding the obtained solid into a solvent B, and then adding formylhydrazine for reaction; 5, filtering, removing the solvent, adding the obtained solid into a solvent C, and then adding oxalic acid for reaction; and 6, drying the solid obtained by filtering to obtain the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate. According to the method, the yield of the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate can be increased, and the production cost is effectively reduced.

The present application relates to a kind of recycling method of avibactam intermediate production waste liquid, belong to pharmaceutical chemical technology field;The present application will be in the 5-benzyloxyamine piperidin-2S-formic acid ethyl ester oxalate in avibactam intermediate production waste liquid by desalination into free state, under the condition of ethyl acetate as solvent, using the dilute solution of m-chloroperbenzoic acid drop, homogeneous reaction in organic solvent, effectively improve the utilization of raw material, with the advantage of less by-product, and have higher recovery rate than prior art, in addition, the present application also prepares a kind of activated carbon loaded sodium triacetoxyborohydride, can play the role of catalytic sodium triacetoxyborohydride reduction amination reaction, improve the utilization of sodium triacetoxyborohydride, and prevent sodium triacetoxyborohydride from contacting with water.

The present application relates to a kind of preparation methods of pressurized water reactor MOX fuel powder, comprising the following steps: by mixed actinide salt and urea solid preparation mixed actinide eutectic, mixed actinide eutectic is directly obtained by deamination, denitrogenation / decarbonation, reduction, MOX fuel powder;The mixed actinide salt is hexavalent actinide nitrate and tetravalent actinide oxalate;When the mixed actinide salt is uranyl nitrate hexahydrate solid and thorium oxalate hexahydrate solid, the MOX fuel powder is (U x Th 1‑x )O2;When the mixed actinide salt is uranyl nitrate hexahydrate solid and plutonium oxalate hexahydrate solid, the MOX fuel powder is (U x Pu 1‑x )O2.The method provided by the present application has simple raw materials, can greatly simplify the preparation process of MOX fuel powder composed of UO2 and PuO2 (or ThO2), reduce the use of process reagent, and does not produce any process waste liquid, thereby providing a simple, high production efficiency, waste liquid-free, more economical and green MOX fuel powder preparation method.

Provided herein are methods for preparing Inonotus obliquus (chaga mushroom) extracts that are substantially free of oxalic acid or oxalate, and to food products containing such extracts.

To provide a crystal of 2 - (4-acetylbenzyl) - 3 - ((4-fluorophenyl) amino) - 577 - trimethyl-7, 8-dihydro-pyrazolo-imidazo [1, 2-a] 2H [4, 3-e] pyrimidin-4 (5H) - one.SOLUTION: Provided is a crystal of an acid addition salt form selected from, for example, succinate form, citrate form, adipate form, tartrate form (e.g., L-tartrate form), malate form, gluconate form (e.g., D-gluconate form), maleate form, fumarate form, aspartate form (e.g., L-aspartate form), hippurate form, sebacate form, glycolate form, galactarate form, benzoate form, pamoate form, oxalate form and malonate form.SELECTED DRAWING: None

This application provides a method for preparing high-whiteness aluminum hydroxide based on oxalate filter cake, belonging to the field of aluminum hydroxide preparation. The method includes: adding sodium oxalate circulating seed to the Bayer process seeding mother liquor to obtain an oxalate filter cake containing aluminum hydroxide; adding sodium carbonate to the oxalate filter cake to adjust the alkali ratio to 0.85–1.15, and adding lime to the oxalate filter cake to obtain a mixture; sintering the mixture to obtain sintered clinker; dissolving the sintered clinker to obtain a sodium aluminate solution; and seeding the sodium aluminate solution to obtain high-whiteness aluminum hydroxide. This application, through precise coupling of process parameters and a full-process design of the impurity control chain, simultaneously achieves deep removal of key impurities such as Fe and Si during the oxalate removal process, transforming the oxalate filter cake from waste into a high-quality raw material for high-whiteness aluminum hydroxide, thus combining the removal of organic matter from oxalate and the preparation of high-whiteness aluminum hydroxide in the Bayer process alumina production.

Provided in the embodiments of the present application is a preparation method for an MOX fuel powder. An MOX fuel powder comprises a plurality of actinide nuclide oxides. The method comprises the following steps: S1, mixing different actinide nuclide salts with urea to form a mixed actinide eutectic system, the actinide nuclide salts being one of hexavalent actinide nitrates, tetravalent actinide nitrates, hexavalent actinide oxalates and tetravalent actinide oxalates; S2, heating the mixed actinide eutectic system obtained in step S1 to a first preset temperature for performing deamination treatment on the mixed actinide eutectic system, so as to remove the urea therein; and S3, heating the product obtained after the deamination treatment in step S2 to a second preset temperature for performing denitrification and / or decarburization treatment on the product obtained in step S2, so as to obtain a plurality of actinide nuclide oxides. Provided in the embodiments of the present application is the preparation method for an MOX fuel powder, which is simple, does not produce a waste liquid, is more economical and environmentally friendly, and can obtain a completely uniform MOX fuel powder.

A lithium primary battery 10 disclosed herein comprises a positive electrode 1, a negative electrode 2, and a non-aqueous electrolyte. The positive electrode 1 contains manganese dioxide. The negative electrode 2 contains at least one among metallic lithium and a lithium alloy. The non-aqueous electrolyte contains: at least one compound selected from the group consisting of oxalate salts, sulfonylimide salts, and isocyanate compounds; and a cyclic imide compound.

The invention relates to the technical field of surface treatment, and discloses a gold plating solution, a preparation method thereof and an electroplating process. According to the total volume of the gold plating solution, the gold plating solution comprises the following components by concentration: 1-20 g / L of gold salt; 100 to 230 g / L of citrate; 20 to 50g / L of oxalate; 0.5-5 g / L of a transition metal additive; 4-10 g / L of an antioxidant; 1-5 g / L of a surfactant; wherein the pH value of the gold plating solution is 4-4.8, and the specific gravity of the gold plating solution is 10-15; the citrate comprises potassium citrate and citric acid; the transition metal additive is selected from at least one of cobalt salt, nickel salt and ferric salt. The preparation method is simple, and the prepared gold plating solution is used for the steps of base material pretreatment, electroplating treatment and aftertreatment in the electroplating process, so that the prepared gold plating product has excellent binding force, wear resistance, corrosion resistance and the like.

The application belongs to the technical field of adsorbing materials, and particularly relates to a high-selectivity strontium adsorbing material, a preparation method and application. The preparation method of the high-selectivity strontium adsorbing material comprises the following steps: loading rare earth ions on collagen fibers to obtain an intermediate material; and reacting an oxalate salt and a dimethylamine cation mixed solution with the intermediate material to generate a MOF crystal material with cavities in situ. The application takes dimethylamine cations as exchange ions, and the crystal structure formed by the coordination of rare earth ions and oxalate ions has a cavity size matching the hydrated ion radius of strontium, and has high selectivity to strontium ions, so that the strontium ions can be removed with high selectivity in the presence of various ions.

The application belongs to the technical field of compound preparation, and particularly relates to a preparation method of an alkali metal salt of an oxalate chelate structure, at least comprising the following steps: mixing tris(trimethylsilyl) phosphate, an oxalate and a phosphorus-containing or boron-containing fluorine compound in a first organic solvent, stirring and heating to obtain lithium phosphate, trimethyl fluorosilane gas, and difluorobisoxalate phosphate or difluorooxalate borate, filtering the reaction solution to obtain lithium phosphate solid and a difluorobisoxalate phosphate solution or a difluorooxalate borate solution; adding a second organic solvent for recrystallization after concentration; and obtaining difluorobisoxalate phosphate or difluorooxalate borate solid after filtration, and drying the solid under reduced pressure to obtain a finished product. The process is simple, and the cost is low. By-products lithium phosphate, potassium fluoride and hexamethyldisiloxane can be directly sold as products after purification. Therefore, the application has an atomic utilization rate close to 100%, no invalid waste, less three-waste emissions, and is friendly to the environment.

Battery comprising: a positive electrode plate, a negative electrode plate, a separator and an electrolyte, wherein: the negative electrode plate has a porosity φ in the unit %; the separator has a thickness t in the unit µm and a pore size R in the unit µm; a ratio of the total mass of the electrolyte to the discharge capacity of the battery N in the unit g / Ah; and the electrolyte comprises an electrolyte additive, wherein the electrolyte additive comprises a sulfate ester compound and a first lithium salt additive, wherein the first lithium salt additive comprises an oxalate-containing lithium salt and the sulfate ester compound has a structure represented by formula I: Formula I, wherein: R1 and R8 are each independently selected from hydrogen or C1 to C5 hydrocarbyl; R2, R3, R4, R5, R6, and R7 each independently from C1- to C3-alkylenes, C1- to C3- alkoxy, an oxygen atom, or are selected; and n is an integer in the range of 0 to 4, and a mass fraction of the sulfate ester compound in the electrolyte C in the unit %; and the battery corresponds to formula A: 0.01 ≤ φ × N × C 10 4 × t × R ≤ 0.5

The invention belongs to the technical field of hydrometallurgy and water treatment, and relates to a method for removing potassium from a lithium-potassium mixed solution with high selectivity and application of the method. The method comprises the following steps: adding oxalate into a lithium-potassium mixed solution, reacting, and carrying out solid-liquid separation; dropwise adding soluble magnesium salt into the filtrate, and reacting; synchronously dropwise adding a sodium dihydrogen phosphate solution and an alkali solution into the solution, controlling the proportion of the sodium dihydrogen phosphate solution and the alkali solution through the dropwise adding speed, and maintaining the pH value of a reaction system to be 8.8-9.2 in the whole process by utilizing an automatic pH control system; and after the reaction is completed, carrying out solid-liquid separation to obtain a low-potassium solution and a potassium magnesium phosphate precipitate. According to the method, low-temperature, synchronous dropwise adding and multi-protection synergistic processes are combined, so that the potassium ions can be efficiently removed, the loss rate of the lithium ions can be reduced to an extremely low level, and the method is suitable for the scenes with extremely high requirements on the retention rate of the lithium ions, such as salt lake lithium extraction and waste lithium battery recovery liquid.

The invention relates to oxalate high-purity barium titanate powder and a preparation method thereof. The method comprises six steps of preparation of a titanium salt stabilizing solution, preparation of a barium salt solution, preparation of a dispersant modified solution, a dispersant synergistic homogeneous precipitation reaction, microwave drying purification and microwave gradient calcination. The purity of the prepared barium titanate powder is greater than or equal to 99.9%, the average particle size is 30-60nm, the aggregate content is less than or equal to 1.5%, the dielectric property is excellent, the barium titanate powder can be widely applied to high-end electronic components such as multilayer ceramic capacitors, the process is stable and controllable, and industrial production is easy.

The invention discloses a preparation method of landiolol hydrochloride, and belongs to the technical field of medicine synthesis. The method comprises the following steps: carrying out condensation reaction on S-3-chloro-1, 2-propylene glycol and acetone under the protection of nitrogen and the action of a catalyst, adding alkali, and concentrating to generate an intermediate I; the method comprises the following steps: adding p-hydroxyphenylpropionic acid, alkali and a phase transfer catalyst into a solvent, and reacting to generate salt; then adding the intermediate I, and reacting to generate an intermediate II; dissolving the intermediate II, R-(-)-epichlorohydrin, alkali and a phase transfer catalyst in a solvent, and reacting to generate an intermediate III; dissolving N-(2-aminoethyl)-4-morpholine amide oxalate in water, adjusting the alkali, adding the intermediate III, and reacting to generate a landiolol crude product; the method comprises the following steps: dissolving a landiolol crude product in a solvent, and adding oxalic acid to react to generate oxalic acid landiolol; and after alkali adjustment, hydrochloric acid ethyl acetate is added to generate landiolol hydrochloride. The method has the characteristics of simplicity and convenience in operation, high yield, stable product quality and environmental friendliness, is good in process repeatability and is suitable for industrial large-scale production.

The application belongs to the field of non-oxide ceramic powder, and discloses a porous high-entropy carbide powder, a preparation method and application thereof. The porous high-entropy carbide powder is prepared by the following steps: adding mixed powder of ammonium metavanadate, ammonium chromate, ammonium niobate oxalate, ammonium molybdate, ammonium metatungstate and ammonium citrate into deionized water, heating in a water bath at 70-80 DEG C until the powder is completely dissolved, drying the obtained ammonium salt aqueous solution at 45-75 DEG C to obtain a high-entropy carbide ammonium salt precursor; then drying and pressing the high-entropy carbide ammonium salt precursor into a blank body, performing heat treatment in a nitrogen atmosphere, heating to 1500-1600 DEG C and keeping the temperature, and cooling after the temperature is finished. The high-entropy carbide powder has a single high-entropy carbide phase, and the surface has a porous structure; the powder particle size is 0.47-0.79 mu m; and the powder is applied in aerospace parts or chemical catalysis.

The invention relates to the technical field of high-temperature alloy precision casting, and discloses a gas turbine blade high-temperature alloy casting method which comprises the following steps: sequentially carrying out lanthanum nitrate dip-coating pretreatment and ammonium carbonate curing treatment on the inner wall of a shell, and converting lanthanum nitrate into a lanthanum carbonate solid interface layer in situ; sequentially dip-coating lanthanum borate surface layer slurry and gadolinium oxide isolation layer slurry on the curing layer to complete shell preparation; dewaxing, sintering and curing the shell at high temperature; high-temperature alloy molten metal is poured into the shell, and metallurgical bonding is formed between the lanthanum borate surface layer and the surface of the casting; keeping the lanthanum borate active layer on the surface of the leaf after shelling; and oxalate-phosphate composite sealing treatment is carried out on pores in the surface layer of the blade. According to the method, integration of casting forming and CMAS-resistant protective layer forming is achieved, the protective layer and the blade base body are metallurgically bonded, the bonding strength is high, micropores in the surface layer of the blade are effectively sealed, and a CMAS permeation channel is blocked.

The invention belongs to the technical field of agricultural biology, and particularly relates to application of ningnanmycin salt to prevention and treatment of tobacco mosaic virus diseases. Derivatives of ningnanmycin salts are developed on the basis of ningnanmycin, and the derivatives comprise ningnanmycin acetate, ningnanmycin lactate, ningnanmycin phosphate, ningnanmycin sulfate, ningnanmycin citrate, ningnanmycin benzoate, ningnanmycin oxalate, ningnanmycin hydrochloride, ningnanmycin nitrate and the like. When the ningnanmycin salts are applied to prevention and treatment of the tobacco mosaic viruses, experiments show that compared with ningnanmycin, the ningnanmycin salts have the advantages that the prevention and treatment effect on the tobacco mosaic viruses is remarkably improved, the prevention and treatment effect of moroxydine hydrochloride can be achieved or even exceeded, and the application prospect is good.

The present application relates to a manufacturing process for a supported transition metal catalyst, a supported transition metal catalyst, and its use in the synthesis of high-carbon ketones by acyloin condensation of α-hydrogen-containing ketones and alcohols. The manufacturing process of the supported transition metal catalyst comprises adding a porous catalyst support to a solution of a transition metal salt, dissolving, standing, drying, calcining, and reducing. The transition metal salt is selected from one or more of the transition metal nitrate, transition metal formate, transition metal oxalate, and transition metal acetate. The transition metal is selected from the transition metal elements of Group VIIB, VIII, IB, or IIB, and the transition metal is not a non-precious metal. The raw materials for the catalyst according to the present application are readily available and inexpensive to produce.The acyloin condensation of α-hydrogen-containing ketones and low-molecular-weight alcohols allows for the highly selective production of desired high-carbon ketones without the need for solvents or hydrogen sources during the reaction. The catalyst is also stable under long-term operating conditions and therefore has good prospects for industrial applications.

The application relates to the technical field of precision casting of high-temperature alloys, and discloses a high-temperature alloy casting method for a gas turbine blade, which comprises the following steps: sequentially performing lanthanum nitrate immersion coating pretreatment and ammonium carbonate solidification treatment on the inner wall of a mold shell, converting the lanthanum nitrate into a lanthanum carbonate solid interface layer in situ; sequentially immersing and coating lanthanum borate surface layer slurry and gadolinium oxide isolation layer slurry on the solidification layer to complete mold shell preparation; performing dewaxing and high-temperature sintering on the mold shell; pouring high-temperature alloy liquid into the mold shell, forming metallurgical bonding between the lanthanum borate surface layer and the surface of the casting; leaving the lanthanum borate active layer on the surface of the blade after shell removal; and performing oxalate-phosphate composite sealing treatment on the surface layer pores of the blade. The application realizes the integration of casting and the formation of a CMAS-resistant protective layer, the protective layer is metallurgically combined with the blade substrate, the combination strength is high, the surface layer micropores of the blade are effectively sealed, and the CMAS infiltration channel is blocked.

This invention belongs to the fields of medicinal chemistry and organic synthesis, specifically relating to a stable 3-aminocyclobutane-1,1-dicarboxylic acid diethyl oxalate and its application in the preparation of 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid. This invention effectively solves the technical bottlenecks of poor stability, difficulty in purification, and storage by converting unstable free 3-aminocyclobutane-1,1-dicarboxylic acid diethyl oxalate into a specific organic acid salt form. More importantly, this invention discovers that this organic acid salt can be directly used as a reaction intermediate, and can be used efficiently in subsequent amide condensation reactions with cholic acid or its active derivatives without the separation of free amines. This method significantly improves the purity and yield of the key intermediate and its downstream product 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid. The process is stable and simple to operate, providing a stable, controllable, and economical preparation route for the industrial production of 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid, a key active pharmaceutical ingredient in the liver cancer prodrug LLC-202.

The application belongs to the technical field of crystal form drug molecules, and relates to zolpidem salts, and a preparation method and application thereof. The application specifically provides zolpidem oxalate, zolpidem fumarate, zolpidem malonate and zolpidem-5-sulfosalicylate methanol compound. The method for preparing the zolpidem salt provided by the application is simple to operate, and the prepared crystal has high purity. The zolpidem salt provided by the application has good chemical stability and good solubility.

This invention discloses a solid waste-based highly active carbon material and its preparation method. It uses industrial waste distiller's grains and spent lithium-ion battery cathode materials as raw materials. The distiller's grains are crushed into particles, while the cathode materials are separated by acid dissolution and oxalate precipitation to obtain a lithium-ion solution and a transition metal oxalate precipitate. Cerium metal salt is added to the precipitate to obtain a non-lithium multi-metal precursor. The resulting distiller's grain particles and multi-metal precursor are then mixed and activated to modify the carbon material with transition metals. Finally, the carbon material is impregnated in the obtained lithium-ion solution and calcined at high temperature to obtain the final solid waste-based highly active carbon material. This invention uses solid waste as raw material and can fully utilize the various active metal components in spent lithium-ion batteries. The resulting solid waste-based highly active carbon material has good capture efficiency for organic molecules in high-temperature exhaust gases, thus possessing promising prospects for large-scale industrial preparation and application.

The invention discloses a chemical synthesis method of avibactam sodium, which comprises the following steps: with (2S)-5-[(benzyloxy) imino] piperidine-2-carboxylic acid ethyl ester as a starting material, carrying out selective reduction under the action of a hand-shaped inducer and a reducing agent to construct 5-site chiral carbon, and carrying out oxalic acid resolution to obtain high-purity oxalate, and then carrying out five-step reaction, namely intramolecular ureization, acylase catalytic hydrolysis amidation, debenzylsulfonic acid esterification salification and sodium ion exchange, so as to obtain the avibactam sodium. According to the method, the chiral inducer is adopted to induce selective reduction, and the acylase catalytic ammonolysis process is optimized, so that the content of isomer impurities in the product is remarkably reduced, and the purity and the overall yield of the product are improved. Wherein the acylase catalytic ammonolysis reaction conditions are mild, and the process safety risk is greatly reduced while the energy consumption is reduced.

The invention relates to the technical field of water pollution control, in particular to a manganese-based composite material and a preparation method and application thereof. The manganese-based composite material comprises a manganese sesquioxide base material and acid radical ions bonded on the surface of the manganese sesquioxide base material. The invention also provides a preparation method of the manganese-based composite material, which comprises the following steps: dissolving an inorganic manganese salt in an inorganic solvent to obtain a solution A; dissolving oxalate in an inorganic solvent to obtain a solution B; adding the solution A into the solution B, carrying out stirring reaction, and carrying out solid-liquid separation to obtain a manganese oxalate precursor; and calcining the manganese oxalate precursor to obtain porous manganese sesquioxide, immersing the porous manganese sesquioxide into an ammonium salt solution, stirring at normal temperature, standing to obtain manganese sesquioxide impregnated with ammonium salt, and calcining to obtain the manganese-based composite material. The invention also provides an application of the manganese-based composite material prepared by the preparation method as a catalyst. The problem that the oxidative degradation capacity of periodate on organic pollutants is limited when periodate is directly used as an oxidizing agent is solved.

This invention belongs to the field of battery recycling, specifically disclosing a coupled electrodialysis recycling method for LFP-LMO cathode materials. The method involves coupled electrodialysis treatment of LFP and LMO cathode materials in an electrodialysis apparatus. The electrodialysis apparatus includes an electrolytic cell and a monovalent permeable cation exchange membrane dividing the electrolytic cell chamber into a cathode chamber and an anode chamber. The cathode chamber contains a cathode, and the anode chamber contains an anode. LFP cathode material and sulfate electrolyte are added to the anode chamber, while LMO and oxalate source electrolyte are added to the cathode chamber. The cathode and anode are electrically connected to the negative and positive terminals of a power source, respectively, for coupled electrodialysis. During the coupled electrodialysis, the pH in the anode chamber is controlled at 1.5–3, and the voltage range is 1–3V. After the coupled electrodialysis is completed, a lithium-rich solution is separated from the solution in the cathode chamber, and M-metal oxalate is separated from the cathode chamber. Iron phosphate is separated from the anode chamber. This invention achieves efficient coupled treatment of LFP and LMO.

The present application relates to a kind of oxalate high-purity barium titanate powder and its preparation method, which comprises six steps of titanium salt stabilizing liquid preparation, barium salt solution preparation, dispersant modification liquid preparation, dispersant synergistic homogeneous precipitation reaction, microwave drying purification and microwave gradient calcination.The purity of barium titanate powder prepared by the present application is ≥99.9%, the average particle size is 30-60nm, the agglomerate content is ≤1.5%, and the dielectric performance is excellent.The present application can be widely applied to high-end electronic components such as multilayer ceramic capacitor, and the process is stable and controllable, easy to industrial production.

The present invention relates to a complementary herbal composition for the treatment of oxalate kidney stones, urinary tract infections (UTIs), and sexual dysfunctions. The composition comprises a synergistic blend of herbal ingredients, including Rumex obstusifolius, Lessertia frutescens, Hypoxis hemerocallidea, Gunnera perpensa, Achillea millefolium, Echinacea purpurea, Taraxacum officinale, Epimedium sagittatum, and Rosa canina L., in specific quantities. The formulation is administered in a water base and preserved with Potassium sorbate. PHYTOCASD offers natural, multi-targeted therapeutic benefits, including dissolving oxalate kidney stones, preventing and treating UTIs, and improving sexual function. The invention is intended for use as a complementary medicine, leveraging the diuretic, antimicrobial, anti-inflammatory, and aphrodisiac properties of its ingredients to provide a comprehensive and safe treatment option for individuals suffering from these conditions.

The invention relates to a device and method for promoting continuous operation of oxalate precipitation through ultrasonic assistance, the device comprises a reactor and a mixer, a stock solution pump and a precipitant pump are respectively connected with the top and the left end of the mixer through pipelines, the mixer is connected with an inlet of the reactor, an outlet of the reactor is connected with an alternate filter, and the alternate filter is connected with a mother liquor storage tank; a nitrate solution and an oxalic acid solution are respectively sent into a mixer for mixing through a stock solution pump and a precipitant pump, and then sent into a reactor for precipitation reaction, slurry is transferred into a filter, and solid-liquid separation is realized through vacuum filtration. The ultrasonic technology is applied to the continuous flow tubular reaction device, formation of oxalate is promoted through the ultrasonic enhancement technology, the reaction liquid mixing effect is further improved, the reaction time is shortened, slurry obtained after reaction is directly filtered, aging time is not needed, and continuous operation of the device is achieved. Meanwhile, the ultrasonic enhancement technology can effectively prevent the pipeline from being blocked, long-term stable operation of the device is achieved, and automatic operation is completed.

The present invention relates to Adagrasib Oxalate of Formula I la in Crystalline Form A: (IIa) The present invention further relates to a process for the preparation of Adagrasib dicarboxylate salt in Crystalline Form, in particular a process for the preparation of Adagrasib Oxalate in Crystalline Form A.