The invention discloses a comprehensive treatment process and a device for electroplating wastewater containing heavy metal ions, Cr6+, Cu2+ and Ni2+. The process includes the steps of completely converting the Cr6+, Cu2+ and Ni2+ ions into hydroxide precipitate, solid-liquid separation by sedimentation, liquid treatment, solid treatment and the like. The device comprises a water collection tank, a chemical reaction tank, a physical sedimentation tank, a filter column, a pH regulating tank, an ion exchanger and a reservoir, which are connected in sequence. The comprehensive treatment process and the device have the advantages that the process guarantees treated wastewater containing the heavy metal ions to meet national standard at lowest consumption of resources, Cr6+ is not larger than 0.2mg/L, Cu2+ is not larger than 0.5mg/L, Ni2+ is not larger than 0.5mg/L, emission is safe, the treatment process is simple, device requirements are low, production cost is saved effectively, daily effectively treating capacity for wastewater is enhanced, requirements of enterprises are met, and environment is protected.