The invention discloses a production process of hafnium disilicide. The production process comprises the following steps: ball-milling and mixing zirconium dioxide powder and silicon powder under a vacuum condition, briquetting by using a hydraulic machine, sintering and finishing in a vacuum sintering furnace, removing white silicon dioxide powder coated on the surface of hafnium, ball-milling ina vacuum ball mill, adding sodium hydroxide, adding distilled water with the temperature of 60 DEG C, and drying to obtain silicon-containing hafnium powder; detecting the content of silicon in the silicon-containing hafnium powder, adding silicon powder according to the content of silicon in the hafnium powder, carrying out ball milling for 5 hours in a vacuum ball mill under the protection of inert argon, putting into a vacuum self-propagating combustion furnace, vacuumizing, heating a thermal electrode, igniting the hafnium powder, making the hafnium powder and the silicon powder carry outa self-propagating combination reaction to obtain hafnium disilicide. Hafnium dioxide powder is used as a raw material, and the raw material cost is lower than sponge hafnium cost; according to the method, the whole process is reasonable in technology and suitable for industrial production, the obtained hafnium disilicide product is high in purity, and the alloying degree can reach 100%.