2results about How to "Reduce compounding efficiency" patented technology

This invention discloses a bismuth-copper bimetallic coordination nanomaterial, its preparation method, and its applications, belonging to the technical field of biofunctional materials. The prepared bismuth-copper bimetallic coordination nanomaterial can efficiently generate reactive oxygen species (ROS) under ultrasonic stimulation, initiating the sonodynamic therapy (SDT) process; the Cu in this material... 2+ The weakly acidic environment of the tumor microenvironment can also trigger a Fenton-like reaction, generating cytotoxic hydroxyl radicals (•OH) and oxygen in situ, thus initiating the chemokinetic therapy (CDT) process. Through the synergistic effect of sonodynamic therapy (SDT) and chemokinetic therapy (CDT), they jointly inhibit cancer cell proliferation and promote T cell generation.

The invention provides an application of Mn-RuO2 in preparation of a medicine for treating cancer, wherein the cancer is pancreatic cancer. A photoelectrochemical test system proves that Mn-RuO2 has the performance expressions of remarkable fluorescence quenching, longest fluorescence lifetime, relatively low charge transfer resistance and strong photocurrent response, and shows that Mn-RuO2 has excellent carrier separation efficiency and low recombination efficiency. Under ultrasonic irradiation, Mn-RuO2 can effectively improve the hypoxic environment and enhance ROS generation, meanwhile, programmed para-apoptosis and pan-apoptosis signal channels in tumor cells are activated, and the synergistically enhanced anti-tumor effect is shown.