The invention relates to a method for preparing a kilogram grade thermistor material. In the method, automatic hydrothermal kettles having volumed of 2L, 5L or 10L, different in volume, are adopted asreaction vessels, and wet chemical synthesis is performed under different packing conditions including 60%, 70% or 80%. A material system adopts Co-Mn-O as matrix, electrical properties and stabilityare regulated through Fe and Zn doping, and influences of optimum reaction conditions including reaction temperature, reaction time, the stirring speed, the degree of packing and a sintering processon material performance are explored. The kilogram grade thermistor material prepared by the method has uniform grain size and high density, and electrical performance parameters are that: B<25/50> is3865-4403 K, Rho<25> is 9.8-26 k[Ohm].cm, and the resistance drift rate is 2.0%-0.2%. The method lays a good foundation for synthesis of heat-sensitive materials in the hydrothermal field and for theengineering application of thermistor elements.