The invention discloses a 2Cr11MoVNbN forge piece for a steam turbine and a manufacturing method of the forge piece. The method comprises the steps that firstly, discharging is carried out; secondly, the charging temperature is raised and controlled to be smaller than 600 DEG C, preheating is carried out for 2 hours, the temperature is raised to 830 DEG C to 850 DEG C at the rising speed smaller than or equal to 150 DEG C/h, the temperature is kept for 3 hours, the temperature is raised to 1160 DEG C to 1200 DEG C at the rising speed smaller than or equal to 150 DEG C/h, the temperature is kept for 5 hours, and cooling is carried out; thirdly, forging is carried out; fourthly, annealing after forging is carried out; fifthly, preheat treatment is carried out, and incomplete annealing is achieved; sixthly, quenched-tempered heat treatment is carried out, wherein the temperature is raised to 1050 DEG C to 1070 DEG C at the rising speed smaller than or equal to 180 DEG C/h, the temperature is kept for quenching for 8.5 h, medium water cooling is carried out, the temperature rises to 620 DEG C to 640 DEG C at the rising speed smaller than or equal to 150 DEG C/h, the temperature is kept for one-time tempering for 16 h, air cooling is carried out, the temperature rises to 620 DEG C to 640 DEG C at the rising speed smaller than or equal to 150 DEG C/h, the temperature is kept for secondary tempering for 16 h, and air cooling is carried out; seventhly, stress relief annealing is carried out. In the forging and heat treatment process, a blank is not prone to cracking, high-temperature durability is good, and the mechanical property of products meets the requirement.