The invention relates to a comprehensive ferment health care nutriment capable of delaying aging and improving human immunity and a preparation method thereof. The nutriment is prepared from the following raw materials in parts by weight: 0.2 to 0.5 part of poria cocos, 0.2 to 0.5 part of Chinese angelica, 0.5 to 1.5 parts of Chinese yam, 1 to 5 parts of wolfberry, 1 to 4 parts of fleece flower root, 0.5 to 2 parts of licorice, 10 to 30 parts of cherokee rose fruit, 10 to 20 parts of pollen, 0.5 to 2 parts of cortex moutan, 1 to 3 parts of dried radix rehmanniae, 0.5 to 1 part of tea, 0.1 to 0.2 part of black fungus, 1 to 3 parts of pig blood, 2 to 8 parts of dorado, 1 to 3 parts of turtle, 5 to 15 parts of orange, 2 to 6 parts of peach, 30 to 50 parts of honey, 5 to 10 parts of brown sugar, and 5 to 20 parts of yeast. The nutriment has the functions of invigorating the spleen, boosting the stomach, dissipating dampness, eliminating rheumatism, enhancing immunity and endurance, preventing virus, relieving fatigue, and strengthening muscles, can effectively improve the micro-circulations of human body, and improves the human immunity.