The invention discloses an ammonia-hydrogen mixed gas power system based on hydrogen ignition and an operation control method, the ammonia-hydrogen mixed gas power system comprises a liquid ammonia supply assembly, an evaporator, a storage pressure stabilizing condenser, a hydrogen supply assembly, an ammonia-hydrogen internal combustion engine, an ammonia cracker, a cooling water pump and a radiator, the ammonia-hydrogen internal combustion engine is provided with a fuel gas channel injection device, a fuel in-cylinder injection device and a cooling system; when the ammonia-hydrogen internal combustion engine is started, the temperature of gas in the ammonia cracker is low, ammonia cannot be subjected to cracking reaction, at the moment, the ammonia cracker does not work, the hydrogen supply assembly supplies hydrogen to the injection device in the fuel cylinder, the injection device in the fuel cylinder injects the hydrogen into all air cylinders of the ammonia-hydrogen internal combustion engine, and ignition and combustion supporting of ammonia are achieved; the problems that when the internal combustion engine is started, the exhaust temperature is low, energy needed by ammonia cracking cannot be provided, and the ammonia-hydrogen internal combustion engine is not started smoothly due to the fact that ignition fuel does not exist are solved, and the energy needed by ammonia cracking comes from cooling and exhaust heat sources of the internal combustion engine and a battery system.