The invention discloses a Chinese herbal medicine control agent for grape diseases and a preparation method of the control agent and belongs to the technical field of Chinese herbal medicine pesticides. The Chinese herbal medicine control agent is prepared from raw materials as follows: 5-8 parts of fructus nandinae domesticate, 5-8 parts of sheaths of sugarcane, 50-80 parts of baijiu, 1-5 parts of fructus rubi, 2-6 parts of ground ivy, 3-6 parts of lychee seeds, 3-6 parts of semen arecae, 4-7 parts of Chinese ilex, 3-8 parts of orange leaves, 2-7 parts of lycoris radiate, 2-6 parts of hemp leaves, 3-8 parts of mint leaves, 1-3 parts of cassia twigs, 2-6 parts of herba lysimachiae, 3-7 parts of houttuynia cordata, 1-5 parts of herbs of spanishneedles, 2-5 parts of perilla frutescens, 3-5 parts of herba lophatheri, 2-5 parts of leaves of zingiber officinale, 1-3 parts of peach twigs, 2-8 parts of cotton seeds, 3-5 parts of herba portulacae and 2-5 parts of peony. The preparation method of the control agent comprises raw material treatment, extraction, spray drying, drying and packaging. The raw materials of the Chinese herbal medicine control agent for grape diseases are all natural materials, are non-toxic, have no residues and are harmless; the production method of the Chinese herbal medicine control agent is simple, easy to operate, low in production cost and convenient to use.