34 results about "Guanidine hcl" patented technology

The invention relates to a method for preparing an uramine-type macromolecule anti-bacterial agent, comprising two steps as follows: A, mixing any one solution of guanidine hcl, Polyhexamethyleneguanidine chloride and polyhexamethylene biguanide hydrochloride with maleic anhydride solution; introducing nitrogen for constant-temperature water bath reaction to obtain functional uramine salt; B, mixing functional uramine salt solution with acrylamide and / or styrene for constant-temperature water bath reaction to obtain ivory-white stringy liquid; depositing soft white solid with solvent for vacuum drying to obtain ivory-white bulk uramine-type copolymer, i.e, uramine-type macromolecule anti-bacterial agent. The uramine-type macromolecule anti-bacterial agent has remarkable effect and simple synthesis process, ensures that the anti-bacterial group is hard to move and the processing thermal stability is excellent through copolymerization on macromolecule long chain. The invention can be widely used in fields of plastic, dope, powder dope, rubber, wood plastic, rubber plastic, spinning, water processing, and the like.

The invention provides a high-efficiency composite guanidine-based paper-making fungicide, which belongs to the technical field of paper-making fungicide production. In parts by weight, the fungicide comprises the following components: 10-30 parts of guanidine-based polymer, N-octyl 5-15 parts of isothiazolinone, 150-450 parts of diethylene glycol, 0.5-1.5 parts of dodecyl dimethyl benzyl ammonium chloride, 0.3-1.8 parts of hydroxymethyl cellulose, o-phenyl Potassium hydrogen diformate 0‑100 parts. The guanidine-based polymer is polyhexamethylene biguanide hydrochloride. Polyhexamethylene biguanide hydrochloride is broad-spectrum antibacterial, has killing ability to Gram-positive bacteria, Gram-negative bacteria, fungi and yeast, and can be used to produce antibacterial paper for health and hygiene products to replace silver-containing libraries At the same time, the polyhexamethylene biguanide hydrochloride solution also improves the physical properties of the paper, water absorption, strength after being wetted with water, and air permeability, so it is a papermaking fungicide with excellent performance. The synergistic effect is a compound TS-302 papermaking fungicide with high efficiency and broad spectrum.

The present invention relates to novel crystalline modifications of N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride, novel N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts and their crystalline modifications and processes of manufacturing and pharmaceutical formulations thereof.

The invention discloses application of polyhexamethylene guanidine in citrus sour rot prevention and treatment, and a citrus antistaling agent containing polyhexamethylene guanidine. The citrus antistaling agent containing polyhexamethylene guanidine comprises: by mass, 0.05 to 0.6% of polyhexamethylene guanidine, 0.05 to 0.2% one or more of imidazole bactericides and benzimidazole bactericides, 0.02 to 0.15% of a polyoxyethylene ether or a quaternary ammonium salt emulsifier, and the balance water. The citrus antistaling agent containing polyhexamethylene guanidine can obviously inhibit decomposition of citrus fruits such as sugar orange fruits and the like in storage, and especially, can inhibit sour rot. If sugar orange fruits treated by the citrus antistaling agent containing polyhexamethylene guanidine is stored at a normal temperature of 15 to 25 DEG C for 40 days, a sour rot incidence of the sugar orange fruits is below 15.4%, wherein a sour rot incidence of a control group is 76%. Therefore, the citrus antistaling agent containing polyhexamethylene guanidine obviously reduces a sour rot incidence of Citrus reticulate Blanco, and greatly improves citrus economic values.

The invention discloses a method for producing adipic acid, hexamethylenediamine hydrochloride and polyhexamethylene (di)guanidine chloride from waste nylon-66 serving as a raw amerial through depolymerization, which is characterized by comprising the following steps of: depolymerizing the waste nylon-66 by using hydrochloric acid to obtain refined adipic acid and hexamethylenediamine hydrochloride; polymerizing the hexamethylenediamine hydrochloride and dicyandiamide (in a molar ratio of 1:1) at the temperature of between 170 and 190DEG C for 1 to 3 hours to obtain a white or pale yellow solid polyhexamethylene diguanidine chloride; and adding dicyandiamide and ammonium chloride powder in a molar ratio of 1:2 into a reactor, performing reaction at high temperature for 1 to 3 hours, slowly adding hexamethylenediamine hydrochloride powder, continuously reacting for 3 to 7 hours to obtain a white or pale yellow solid polyhexamethylene guanidine chloride. The method improves production efficiency, reduces production cost, and solves the problems of difficult separation of the product hexamethylenediamine due to depolymerization, low yield and poor benefit; and the technological process is environment-friendly, simple and convenient, and is suitable for industrial production.

The invention relates to a preparation method for recombinant human granulocyte colony stimulating factor (recombinant human granulocyte colony stimulating factor, rhG-CSF). The refolding solution consists of Guanidine-HCl, Urea, Tris-HCl, Cysteine, Cystine and Glycerol ) and other components. Using the refolding solution to refold rhG-CSF inclusion bodies, the refolding process is simple, and the finished product has high purity and good stability.

The invention relates to a preparation method of polyguanidine adipate hydrochloride. Mix adipic acid and guanidine hydrochloride evenly, heat and melt, heating temperature is 120-160°C; add catalyst; add molecular weight regulator; the whole reaction process is subjected to water separation step, after the reaction is completed, immediately add to absolute ethanol and cool to room temperature , recrystallized, and filtered to obtain polyadipate-based guanidine hydrochloride. The polyguanidine adipate hydrochloride of the present invention improves the structure of the polyguanidine disinfectant, and introduces an electron-withdrawing group acyl group to make the guanidine group more positively charged, so its bactericidal ability is stronger.

A process method for synthesizing 1,5,7-triazabicyclo[5.5.0]dec-5-ene (TBD) in an autocatalytic amphipathic mixed solvent. In the process method in the present invention, di(3-amino propyl)amine and guanidine hydrochloride are used as raw materials, and the TBD is synthesized in the hydrophilic-hydrophobic amphipathic mixed solvent at a high yield by using trace TBD (0.001%-0.005%) as a catalyst. The method has the characteristics that the process operations are simple and convenient, the yield of the target product is high (≥95.0%), and the product purity is high (≥98.0%).

The invention relates to a method for preparing a nano-hydroxyapatite / polyhexamethylene monoguanidine hydrochloride / silica gel composite material. The salt load is prepared on silica gel. First, the silica gel is activated, and then the mass ratio of nano-hydroxyapatite to activated silica gel is 1:5-1:30, and polymethylene monosodium chloride with a concentration of 0.25-1.0% is added. Guanidine hydrochloride solution, ultrasonic vibration, centrifugation, and drying in a vacuum oven to obtain the finished product. The invention is a solid-phase extraction adsorption material, which avoids the disadvantages of easy loss and blockage of pipelines during use of a single nanometer material. The enrichment effect on Cr(Ⅵ) is ideal, and it can be used for speciation analysis of chromium in environmental water samples. Reusable at least 20 times.