The invention discloses a production method of a high-moisture-proof and medium-density fiber wardrobe special plate. The production method comprises the following steps of (1) raw materials pretreating, (2) screening, (3) cooking and softening, (4) grinding, (5) gluing and drying, (6) prepressing, (7) hot pressing, (8) sawing and sanding, (9) veneering and hot pressing, (10), edge sealing, and afinished wardrobe special plate is obtained. According to the production method, barks and branches of eucalyptus and waste leftover materials left in the plate manufacturing process are taken as mainraw materials, then pine wood, basswood, birch wood, weeping willow wood, zelkova wood, aceraceae wood, willow wood and the like are added, the waste is changed into wealth, and the wood resources can be fully and effectively utilized; the produced medium-density fiber wardrobe special plate has the advantages of being good in moisture-proof performance, good in water resistance, low in formaldehyde content, high in strength and good in toughness, and the wardrobe special plate is safe, environment-friendly, attractive, wear-resistant and practical.