128 results about "Cu-Zn Superoxide Dismutase" patented technology

Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.

The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.

The invention discloses river crab feed, which comprises fish meal, vegetable dregs, corn, soya bean meal, inferior meal, soya-bean oil, shrimps, cuttlefish ointment, monocalcium phosphate, mineral substances for crabs, vitamin for the crabs, a binder, 0.7 to 14.0 mg/kg of cordycepin, 131.0 to 2,620.0 mg/kg of cordycepic acid, 0.1 to 2.0 mg/kg of adenosine and 290.0 to 5,800.0 IU/kg of superoxide dismutase. The river crab feed has the high utilization rate, reduces the pollution of feed residues to environment, avoids the negative effects of antibiotic residues and tolerance caused by the antibiotic residues, is safe and harmless to the craps and the environments and can enhance the immunity of the crabs and accelerate the growth of the crabs. The invention also provides a production process of the river crab feed, which has the characteristics of low cost and simple and convenient operation.

The invention discloses a whitening sunscreen cosmetic and a preparation method and application thereof. The whitening sunscreen cosmetic consists of the following components in percentage by weight: 5 to 8 percent of emulsifier, 15 to 25 percent of fat, 0.5 to 1.5 percent of antioxidant, 30 to 50 percent of deionized water, 3 to 6 percent of wetting agent, 0.3 to 0.5 percent of emulsifier, 0.3 to 0.5 percent of stabilizing agent, 0.1 to 0.3 percent of penetrating agent, 10 to 15 percent of sun-screening agent, 0.5 to 4.0 percent of mixed tartaric acid solution, 0.3 to 0.8 percent of retinol, 0.5 to 1.0 percent of lactobacillus/soybean fermented product, 0.1 to 1.5 percent of bacillus fermented product, 0.1 to 0.5 percent of superoxide mutase, 1.0 to 4.0 percent of asafoetida root extract and 0.3 to 0.8 percent of preservative. The whitening sunscreen cosmetic can be used for daily skin beauty care, provides long-term and safe sunscreen effect for skin, has the effects of improving skin gloss, whitening the skin, eliminating facial acnes and diminishing wrinkles, and solves problems of yellow face, no gloss and the like.

The invention provides a herbal composition and an application thereof; the composition includes radix asparagi and rhizoma rehmanniae or also includes ginseng; the composition can improve the activity of superoxide dismutase SOD and hyaluronic acid synthase HAS3 in skin fibroblasts by promoting proliferation of the skin fibroblasts so as to achieve good biological-activity antioxidant anti-aging and moisturizing effects, and can achieve antioxidant anti-aging and moisturizing double effects when added to cosmetics and/or skin care products.

The present invention relates to external liquid and solid kreotoxin (argireline) composite nanometer latex for skin and a preparation method thereof. The weight proportion of each raw material of liquid nanometer latex is 10g of isopropyl myristate, 2g of vitamin E, 0.8g of vitelline lecithin, 0.2g of ginseng saponin, 0.01g of rhodiola element, 0.005g of the argireline, 0.001g of superoxide dismutase, 0.5g of reduction type glutathione, 5g of fetal calf serum, 0.05g of hyaluronic acid, 0.05g of ceramide, 40g of distilled water, 36g of polyethylene glyceride glycol caprylic decanoate and 12g of polyglycerol fatty acid ester; the weight proportion of each raw material of solid nanometer latex is 10g of the isopropyl myristate, 2g of the vitamin E, 0.8g of the vitelline lecithin, 0.2g of the ginseng saponin, 0.01g of the rhodiola element, 0.005g of the argireline, 0.001g of the superoxide dismutase, 0.5g of the reduction type glutathione, 5g of the fetal calf serum, 0.05g of the hyaluronic acid, 0.05g of the ceramide, 40g of the distilled water, 36g of the polyethylene glyceride glycol caprylic decanoate, 12g of the polyglycerol fatty acid ester, 22g of mannitol and 3g of glycin.

The present invention concerns an antibody which specifically binds to an abnormal superoxide dismutase 1 (SOD1), and which neutralizes its pathologic effect when administered to an animal such as a human. The antibody of the invention is a monoclonal antibody produced by hybridoma cell lines deposited with the International Depositary Authority of Canada on Aug. 29, 2006 under accession numbers ADI-290806-01, ADI-290806-02 and ADI-290806-03. The present invention also concerns the use of the antibody of the invention in the treatment, prevention and diagnosis of neurodegenerative diseases such as Amyotrophic lateral sclerosis, Parkinson and Alzheimer in an animal such as a human.

The invention provides a superoxide dismutase fertilizer and a preparation method thereof, relating to the field of fertilizer production. The superoxide dismutase fertilizer is composed of the following raw materials in parts by weight: 30-40 parts of urea, 10-20 parts of potassium chloride, 20-30 parts of monoammonium phosphate, 15-20 parts of ammonium chloride, 0.05-0.15 part of rapin, 0.01-0.03 part of zymoprotein, 4-5 parts of adhesive, 0.5-0.8 part of polyaspartic acid, 0.1-0.2 part of superoxide dismutase, 0.1-0.5 part of microzyme and 0.3-0.5 part of amino acid liquid. The superoxide dismutase can improve the crop metabolism, accelerate the growth and division of cells and promote crop growth, thereby further regulating the metabolism of plants to organic pollutants and lowering the plant contamination risk. The effective addition of the microzyme can prevent roots and fruits from rotting, has favorable antagonistic effect and reduces the consumption of the insecticide. The added polyaspartic acid activates the nutrients nitrogen, phosphorus and potassium in the soil, and also activates calcium, magnesium, molybdenum, zinc and other secondary and micro nutrients, thereby satisfying multiaspect demands for crops, reducing the fertilizer consumption, conforming to the national fertilizer reduction policy and promoting the development of the industry.

The invention relates to functional food white spirit, in particular to white spirit with SOD (superoxide dismutase) added and SOD activity improved and a white spirit preparation process. Activity of SOD in the spirit can be maintained for a long time and kept stable, and the activity of SOD can be improved by adding active substances.

The invention relates to a synchronous repair and sunscreen composite nano emulsion for skin injury from ultraviolet A radiation and ultraviolet B radiation and a method for preparing the same. The product is prepared from the following raw materials in percentage by mass: 9.0 to 13 percent of isopropyl myristate, 25.0 to 33 percent of caprylocaproyl macrogolglyceride, 8.5 to 15 percent of polyglyceryl fatty acid ester, 33 to 46 percent of triple distilled water, 0.002 to 0.004 percent of superoxide dismutase, 0.25 to 0.4 percent of glutathione, 1 to 3 percent of vitamin E, 1.5 to 3 percent of coenzyme Q10, 0.8 to 1.6 percent of 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-diketone, 2.0 to 5.0 percent of ethylhexyl methoxycinnamate, 0.6 to 2.0 percent of 4-methyl benzylidene camphor, 0.03 to 0.2 percent of ethylene diamine tetraacetic acid, 0.05 to 0.3 percent of citric acid and 0.5 to 2.0 percent of sodium citrate. The composite nano emulsion greatly improves the stability, safety and sunscreen effect of the sunscreen functional ingredient, can prevent the skin from being further damaged by the ultraviolet radiation and synchronously achieve the repair effect while serving as sunscreen.

The invention discloses a method for preparing gene recombinant human superoxide dismutase liposome enteric-coated capsules, which prepares Cu-Zn superoxide dismutase liposome enteric-coated capsules by embedding human Cu-Zn superoxide dismutase (specific activity: 18000U/mg) obtained by the fermentation of engineering bacteria into a liposome. The liposome serving as embedding material adopts the mucosa to absorb the phosphatide and cholesterol of an enhancer, the vitamin E of an antioxidant is added into the liposome, and the enteric-coated capsule which can prevent liposome pharmaceuticals from decomposition and destruction by gastric juice is adopted to avoid the destruction of the medicine, so the gene recombinant human superoxide dismutase liposome enteric-coated capsule can strengthen the absorption of the human Cu-Zn superoxide dismutase, improve the blood concentrations and pesticide effect, remove the free radical from human body better, and delay the process of aging. The encapsulation ratio of the human Cu-Zn superoxide dismutase (Cu-Zn SOD) liposome is 80.54 +/- 2.26 percent, and the tolerances of the enteric-coated capsule under the simulated condition of gastric acid, pepsin and pancreatic enzyme in vitro are respectively 95.2 percent, 91.6 percent and 86.2 percent.

This invention relates to compositions which enhance a mammal's immune response to a cytokine by administering therapeutic amounts of catalysts for the dismutation of superoxide which include superoxide dismutase enzyme (SOD) and small molecular weight organic ligand mimics of that enzyme (SOD mimetics or SODms), alone or in combination with a cytokine. These compositions may be used in methods for enhancing a mammal's immune response to a virus such as the hepatitis C virus or the human immunodeficiency virus (HIV) or to a tumor thereby inhibiting the proliferation of the tumor. Relatedly, these compositions may be used in methods of treating mammals infected with HIV or mammals suffering from Hepatitis C or AIDS. This invention also relates to methods of enhancing cancer therapy and methods of preventing and treating hypotension in a mammal resulting from the administration of cytokines by the administration of therapeutic amounts of catalysts for the dismutation of superoxide in combination with a cytokine and catecholamine pressor agents. Also provided are pharmaceutical compositions comprising catalysts for the dismutation of superoxide alone or in combination with cytokines and catecholamine pressor agents for use in the above methods.

The invention relates to a method for extracting superoxide dismutase (SOD) from porcine blood red cells, in the method, anticoagulation treatment is adopted for preventing blood coagulation and breaking of blood cells. Colloid mill breaking and low-temperature swelling are adopted for releasing matters dissolved in the blood cells to the maximum extent so as to get hemolysate. Thermal change is performed on the hemolysate twice for removing impurities, removing hemoglobin and a large number of impurity proteins so as to get SOD crude enzyme liquid, and ultrafiltration concentration, gradient elution, dialysis, salt removal and freeze-drying are further performed on the SOD crude enzyme liquid so as to get an SOD product. The method is simple to operate and easy to master; furthermore, by adopting the method, the product quality can be effectively improved, the production cost can be reduced, the production cycle can be shortened, the production efficiency can be improved, and the method is applicable to industrialized production.

The present invention discloses a medical ray protection spray capable of protecting human body against injury due to radiation ray The effective components of said spray include (by wt%) 0.002-0.3% of superoxide dismutase, 0.01% of pentose, 0.1% of polyethylene glycol 6000, 0.1% of witamin C 0.1% of potassium sorbate and the rest is distilled water. Besides, said invention also provides its preparation method.

The invention discloses a method for extracting superoxide dismutase (SOD) from pig blood. The method comprises the following steps of separating blood cells from blood plasma by a separation-cleaning-disruption integrated one-step separation technology and preparing a blood solution, treating the blood solution by an ethanol-chloroform dissolution and precipitation technology to obtain a crude enzyme solution, treating the crude enzyme solution by an acetone precipitation method to obtain a SOD crude protein, heating supernate obtained by the previous step for degeneration, collecting supernate, removing precipitates, carrying out further separation and purification of the supernate by a spiral gradient elution technology to improve enzyme unit activity and obtain a purified SOD enzyme solution, filtering the purified SOD enzyme solution by a membrane for desalination, and carrying out freeze drying to obtain a purified SOD product. The method simplifies production technology and production equipment, and satisfies requirements of large-scale industrialized production.

Without-make-up essence composite cream and liquid includes without-make-up essence nutrient liquid and without-make-up essence youth cream. The without-make-up essence nutrient liquid includes the following components: an A phase including: 6-8% of glycerin, 2.4-4% of trehalose, 0.1% of methylparaben and the balanced being water; a B phase including: 0.5-0.8% of sodium hyaluronate; a C phase including: 2-4% of hamamelis virginiana extract, 1.5-5% of ceramide-1, 2-3% of hydrolysis elastin, 1.5-2% of caffeine, 1-2% of superoxide dismutase, 0.3-0.5% of dipotassium glycyrrhizinate, 0.3% of bis(hydroxymethyl)imidazolidinyl urea and 0.1% of essence. The without-make-up essence composite cream and liquid has natural make-up sense, is excellent in coating performance on skin, has a refreshing feel and has high cleaning effect, and also has the effects of protecting skin.

The invention discloses a chicken forage containing a raw material acanthopanax senticosus. The chicken forage is prepared from the following raw materials in percent by weight: 300-450 parts of corn, 100-120 parts of soybean meal, 60-80 parts of sorghum, 50-60 parts of wheat middling, 30-40 parts of rice bran, 20-30 parts of shell powder, 20-30 parts of pieris rapae powder, 40-50 parts of sweet potato powder, 10-15 parts of garlic, 12-15 parts of black fungus, 10-15 parts of mulberry leaf powder, 8-10 parts of lotus root starch, 10-15 parts of acanthopanax senticosus and 4-5 parst of a feeding promoting agent. Acanthopanax senticosus contains a large amount of biological activity factors, and is capable of enhancing body immunization capability, improving body circulation environment, balancing glycolipid metabolism; superoxide dismutase SOD compound contained in acanthopanax senticosus has extremely good antioxidation capability; and additionally, acanthopanax senticosus is abundant in vitamins, mineral matters and multiple amino acid, is capable of well supplementing nutrition of the forage, improving production performance of egg-laying chicken, laying rate of the egg-laying chicken and the weight of laid eggs, and prolonging egg-laying period as well as enhancing immunization capability.

The invention provides an essence used for treating whelks and pigmentation spots and whitening. The essence comprises the following components in parts by mass: 1-3 parts of a trace element composition, 3-5 parts of collagen, 25-35 parts of hydrogen-rich oxygen-rich water, 0.1-0.5 part of hyaluronic acid and 1-5 parts of superoxide dismutase, wherein the trace element composition is one or two of zinc gluconate and sodium selenite, the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-rich water. The specific activity of the superoxide dismutase is 1000-2000 IU/mg. The essence of the invention has small irritation and no toxic and side effects, is capable of effectively removing whelks and pigmentation spots, and also has whitening effect.

The invention discloses a stauntonvine enzyme rich in superoxide dismutase SOD and a preparation method thereof. The content of the stauntonvine enzyme rich in superoxide dismutase SOD is 300-800U/mLprot. The preparation method comprises the following steps: quickly freezing the pretreated stauntonvine under low temperature and then breaking and pulping; adopting a complex enzyme preparation for performing low-temperature enzymolysis; lastly, adding a compound fermenting agent and fermenting under an ultrasonic-assisted condition, thereby acquiring the product, wherein the fermenting period ofthe whole preparation technology is 8-10 days. According to the invention, preparing the stauntonvine enzyme rich in superoxide dismutase SOD by taking stauntonvine as a raw material not only can effectively shorten the fermenting period of the enzyme but also can extremely keep bioactive components of stauntonvine; the acquired stauntonvine enzyme tastes delicious, is rich in nutritional ingredients and is high in concentration of bioactive components; the stauntonvine enzyme can be used as an intermediate product for producing stauntonvine oral liquid, beverage, wine, tea, tablet, capsule,power and food additive.

The invention provides a cordyceps sinensis three-animal-penis wine and a method for producing the cordyceps sinensis three-animal-penis wine. The problems of decreasing resources of the existing wild cordyceps sinensis, severe disordered mining phenomenon, seriously damaged environment, severe soil erosion and expensive use price are solved. The cordyceps sinensis three-animal-penis wine comprises the following material constituents : white sprit, 0.001-50 parts of cultured cordyceps militaris and 0.01-0.15 parts of three-animal penis. By adopting the cultured cordyceps militaris, the problems of decreasing resources of the existing wild cordyceps sinensis, severe disordered mining phenomenon, seriously damaged environment, severe soil erosion and expensive use price are effectively solved; the cordyceps militaris contains cordycepic acid, cordycepin, cordyceps polysaccharide, superoxide dismutase (SOD) and microelement selenium, so that the health protection and rehabilitation actions of the three-animal-penis wine are greatly enhanced; in addition, the cost is lower than that of the wild cordyceps sinensis, the action can completely replace the wild cordyceps sinensis, and the environment is effectively protected.

The invention discloses medical ray protection spray. The protection spray is prepared from active ingredients including SOD (superoxide dismutase), curcumin, sodium alginate, potassium sorbate and sorbitol, and purified water. For the ingredients adopted by the medical ray protection spray, curcumin has the efficacies of resisting bacteria, resisting inflammation and easing pain, potassium sorbate can inhibit the microbial growth, sorbitol has the moisturizing function, meanwhile, sodium alginate is large in molecular weight, the interior of the space structure of sodium alginate contains many loose micropore structures which can wrap SOD in the gel form, and moreover, sodium alginate has the capacity of forming gel, thus improving the stability of SOD (superoxide dismutase). After the protection spray is sprayed to the skin surface of a patient, sodium alginate can control SOD, so that SOD is slowly released, and therefore, the drug action of the product is prolonged and improved.

The invention relates to the technical field of steam hot compress eye patch heating packets, and discloses a formula of a novel steam hot compress eye patch heating packet. The steam hot compress eyepatch heating packet is prepared from 85 g of non-woven fabric, 450 g of vermiculite, 2,800 g of iron powder, 150 g of salt, 980 g of water, 10 g of resin, 2 g of superoxide dismutase, 15 g of hyaluronic acid, 3 g of natural plant extract essence, 6,200 g of activated carbon, 4 g of transparent thin films and 3 g of sleep-helping sachets. The non-woven fabric is divided into two layers, wherein an LMDK-PET drenching and coating cloth is adopted as the lower layer, a T650 breathable cloth is adopted as the upper layer, the natural plant extract essence is composed of lavender, chamomile and rose essence, and the ratio of the lavender to the chamomile to the rose essence is 3:3:4. According to the formula, through the arrangement of the dual-layer non-woven fabric, powder raw materials canbe effectively packaged, and the air inlet amount is controlled; it is guaranteed that heat quantity cannot be increased to the maximal value (about 90 degrees) for raw materials which can be reacted,and the eyes are prevented from being harmed; meanwhile, the temperature can be increased to the temperature of 50 DEG C or so which is most comfortable to the eyes within the shortest time, and it can also be guaranteed that the steam volatilization quantity can achieve the best effect.

The invention discloses an imidazolyl copper complex and a preparation method and application thereof. The imidazolyl copper complex is a binuclear imidazolyl copper complex shown by formula (I) or a mononuclear imidazolyl copper complex shown by formula (II); the chemical formula of the binuclear imidazolyl copper complex is [Cu2(HL)2(L)2](ClO4)2, and the chemical formula of the mononuclear imidazolyl copper complex is [Cu(HL)2(Phen)](ClO4)2, wherein HL represents N-methyl-2-hydroxymethyl imidazole, L represents the group formed by removing H from the hydroxyl of the hydroxymethyl on the site 2 of HL, and Phen represents 1,10-o-phenanthroline. By adopting the method disclosed by the invention, the structure of the prepared imidazolyl copper complex is similar to the unique imidazole bridging copper-zinc hetero-binuclear structure of the SOD (superoxide dismutase) active center of bovine red blood cells, and then the complex can be used as a water-soluble mimic superoxide dismutase for efficiently clearing superoxide anion free radicals.