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35 results about "Cutting agent" patented technology

A cutting agent is a chemical used to "cut" (dilute or adulterate) recreational drugs with something less expensive than the drug itself.

Bridged cycle‑based inhibitors of DNA‑dependent protein kinase and compositions and application in gene editing

PCT designated stage expiredWO2025049253A1Organic chemistryEnzymesPharmaceutical drugA-DNA
The present disclosure is directed to DNA-PK inhibitors having the Formula (I), (I) or a pharmaceutically acceptable salt, stereoisomer, solvate, prodrug, or tautomer thereof, methods of preparing the foregoing, and compositions thereof, as well as methods of use for the compounds of Formula (I), in combination with a DNA cutting agent.
Owner:JUNO THERAPEUTICS INC

6,6-core silacycle based inhibitors of DNA-dependent protein kinase and compositions and application in gene editing

PCT designated stage expiredWO2025049250A1Silicon organic compoundsHydrolasesA-DNAStereoisomerism
The present disclosure is directed to DNA-PK inhibitors having the Formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, prodrug, or tautomer thereof, methods of preparing the forgoing, and compositions thereof, as well as methods of use for the compounds of Formula (I), in combination with a DNA cutting agent.
Owner:JUNO THERAPEUTICS INC

5,6-core silacycle based inhibitors of DNA-dependent protein kinase and compositions and application in gene editing

PCT designated stage expiredWO2025049247A1Silicon organic compoundsHydrolasesA-DNAStereoisomerism
The present disclosure is directed to DNA-PK inhibitors having the Formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, prodrug, or tautomer thereof, methods of preparing the forgoing, and compositions thereof, as well as methods of use for the compounds of Formula (I), in combination with a DNA cutting agent.
Owner:JUNO THERAPEUTICS INC

Preparation method and application of environment-friendly flame-retardant coolant

The invention relates to the technical field of flame-retardant cutting agents, in particular to a preparation method and application of an environment-friendly flame-retardant cooling agent. Comprising the following steps: 1, carrying out an esterification reaction on 2, 2, 2-trichloroethanol and 2, 4, 6-tri (aminocaproic acid)-1, 3, 5-triazine to obtain a triazine polycarboxylic acid ester; (2) grafting the triazine polycarboxylic acid ester and DOPO (9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) to obtain triazine polycarboxylic acid ester-DOPO; (3) under an alkaline condition, carrying out a hydrolysis reaction on the triazine polycarboxylic acid ester-DOPO, and then carrying out acidizing treatment to obtain triazine polycarboxylic acid-DOPO; step two, (1) reacting hydroxyl-terminated fluorosilicone oil with epoxy chloropropane, and epoxidizing the hydroxyl-terminated fluorosilicone oil to obtain epoxy-terminated fluorosilicone oil; (2) reacting the epoxy-terminated fluorosilicone oil with diethylenetriamine to obtain hyperbranched hydrophilic fluorosilicone oil; and 3, mixing the triazine polycarboxylic acid-DOPO, the hyperbranched hydrophilic fluorosilicone oil and other raw materials to obtain the environment-friendly flame-retardant coolant.
Owner:JIANGSU YINGJIE ENERGY TECHNOLOGY CO LTD

Sled brake

Semi-automated cable stripping device comprising a mechanical mount, a clamping system wherein the clamping system is fixedly arranged on the mechanical mount, a stripping carriage wherein a cutting system is arranged on the stripping carriage, wherein the cutting system comprises at least one cutting means and wherein the cutting system is closed when the stripping carriage moves in a stripping direction and is open when the stripping carriage moves in an approach direction, a displacement carriage wherein a displacement cam is arranged on the displacement carriage, wherein the displacement cam is configured for actuating the clamping system, a drive system wherein the drive system is configured for moving the stripping carriage and / or for moving the displacement carriage, preferably by means of rotation of a drive spindle, a deceleration system wherein the deceleration system at least temporarily inhibits movement of the stripping carriage.wherein the delay system is activated when the pull-off carriage moves in the approach direction and is released when the pull-off carriage moves in the pull-off direction.
Owner:GLW GMBH

Organopolysiloxane composition as well as preparation method and application thereof

The invention relates to the technical field of structural bonding and sealing, in particular to an organopolysiloxane composition as well as a preparation method and application thereof. The organopolysiloxane composition comprises the following components in parts by weight: 80-100 parts of organopolysiloxane of which each molecule at least comprises two alkenyl groups; 2 to 25 parts of organopolysiloxane, each molecule of which at least contains two Si-H bonds; 0.001 to 2 parts of a complexing type platinum catalyst; and 0.5-5 parts of a low-temperature adhesion promoter. The composition disclosed by the invention can be quickly bonded and strengthened within 5-10 minutes at the temperature of 80 DEG C or above by matching a complexing platinum catalyst with a low-temperature bonding accelerant, 80% or above of complete curing is achieved, and meanwhile, the composition can be kept for more than 48 hours at room temperature; in addition, the anti-interference and anti-poisoning capacity is obviously improved, and under the condition that a scaling powder or a water cutting agent exists, the degree of influence on the bonding strength after the snap-cure process is obviously reduced.
Owner:YANTAI DARBOND TECH

An anti-220 deg. c saturated salt environment-friendly water-based drilling fluid and a preparation method and application thereof

The application provides an anti-220 DEG C saturated salt environment-friendly water-based drilling fluid and a preparation method and application thereof.The anti-220 DEG C saturated salt environment-friendly water-based drilling fluid comprises the following raw materials in parts by weight: 100 parts of water, 1-4 parts of a composite soil cutting agent, 0.2-0.6 parts of sodium hydroxide, 3-6 parts of an anti-high-temperature and anti-salt zwitterionic polymer, 2-4 parts of an anti-high-temperature and anti-salt anionic polymer, 3-5 parts of an alcohol amine inhibitor, 6-10 parts of organic-inorganic hybrid microsphere plugging agent, 2-4 parts of a strong adsorption anti-sloughing plugging agent, 3-4 parts of a composite oil lubricant, and 0.5-1 parts of a system stabilizer.The water-based drilling fluid can maintain good rheological properties, filtration loss, plugging and anti-sloughing properties under the condition of 220 DEG C or above, saturated sodium chloride and 3% calcium chloride.The drilling fluid system does not contain sulfonated materials, the treatment agent used has strong high-temperature and high-salt resistance, is not decomposed under high-temperature and high-salt conditions, and has good environmental protection performance.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)

Waste gas treatment device of cutting agent production line

The utility model relates to the technical field of cutting agent production, in particular to a waste gas treatment device of a cutting agent production line, which not only treats waste gas by using various modes such as centrifugal separation, alkaline solution and activated carbon, enhances the treatment effect, but also accelerates the flow rate of the waste gas and improves the treatment efficiency. Comprising a treatment cylinder; the waste gas treatment device further comprises a gas inlet mechanism, a gas extraction mechanism, a dust removal mechanism, a spraying mechanism and a cleaning mechanism, the gas inlet mechanism is installed on the treatment barrel and conveys waste gas into the treatment barrel, the gas extraction mechanism is installed on the treatment barrel and accelerates exhaust of the treated waste gas, and the dust removal mechanism is installed on the gas extraction mechanism and separates dust in the waste gas. The spraying mechanism is mounted on the treatment cylinder and neutralizes acid gas in the waste gas, and the cleaning mechanism is mounted on the spraying mechanism and flushes the dust removal mechanism.
Owner:DALIAN AIDUOWEI STEEL SURFACE TECH CO LTD

Hydrophobic monomers, high molecular weight polymers, methods of making the same, and water-based drilling fluids and applications

The application relates to the field of petroleum drilling aids, in particular to a hydrophobic monomer, a high-molecular polymer and a preparation method thereof, and a water-based drilling fluid and application, and provides the hydrophobic monomer with a structural formula shown in formula (I) and a preparation method thereof, on the basis of which a high-molecular polymer and a preparation method thereof are provided, and a water-based drilling fluid and application are provided. The high-molecular polymer provided by the application is used as a high-cutting agent for the water-based drilling fluid, can improve the dynamic cutting force of the drilling fluid while showing a lower tackifying effect, can be used as an ideal flow pattern regulator, has outstanding temperature resistance and salt resistance, has better weather resistance, and is environment-friendly.
Owner:CHINA PETROLEUM & CHEMICAL CORP +1

Aluminothermic high heat cutting agent, its preparation method and application

ActiveCN117483937BPtru catalystSlag
The application provides a high-heat cutting agent based on an aluminothermic agent and a preparation method and application thereof, and belongs to the technical field of high-heat cutting agents. The high-heat cutting agent is prepared by taking a composite aluminothermic agent as a heat-producing agent, taking a composite of NaCl, KCl, CaF2, AlCl3 and Na3AlF6 as a diluent, taking a composite of Katoxin and Ni powder as a combustion catalyst, taking BaO2 as a gas-producing agent, and taking a composite of NC and GAP as an energetic binder. The high-heat cutting agent has the advantages of intense combustion, high heat, and short melting time of steel plates, and has the advantages of little amount of slag after melting the steel plates and no hole blocking phenomenon.
Owner:ZHONGBEI UNIV

Organic ultraviolet ray cut agent capsules having an effect of increasing ultraviolet ray cut efficiency

The present invention relates to an inorganic encapsulation technology for an organic ultraviolet absorber with enhanced temporal stability and ultraviolet cut-off efficiency, and a method for producing the same. In the present invention, an organic UV filter is encapsulated by an encapsulation reaction of an encapsulation component, and at the same time, stabilization conditions of the produced microcapsule emulsion are realized, and high-temperature and temporal stability can be ensured.
Owner:エルジー·エイチアンドエイチ·カンパニー·リミテッド

Pyrazolopyridine based inhibitors of DNA-dependent protein kinase and compositions and application in gene editing

PCT designated stage expiredWO2025049254A1Organic active ingredientsOrganic chemistryA-DNAStereoisomerism
The present disclosure is directed to DNA-PK inhibitors having the Formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, prodrug, or tautomer thereof, methods of preparing the forgoing, and compositions thereof, as well as methods of use for the compounds of Formula (I), in combination with a DNA cutting agent.
Owner:JUNO THERAPEUTICS INC

An oil-based fluid loss additive, its preparation method and its use in drilling fluids

PendingCN122302844ACompound aPhysical chemistry
This application provides an oil-based cutting agent, obtained by reacting a polybasic acid sequentially with an amino compound A, an amino compound B, an amino compound C, and a long-chain alkyl acid, followed by dilution. The amino compound A is an alkenyl polyamine; the amino compound B is an alkyl diamine; and the amino compound C is an alkyl alcoholamine. This application also provides a method for preparing the oil-based cutting agent and a drilling fluid. This application involves sequentially reacting an alkenyl polyamine, an alkyl diamine, and an alkyl alcoholamine with a polybasic acid, followed by chain extension with a long-chain alkyl acid, and finally dilution to obtain an oil-based cutting agent that can effectively improve the shear force of oil-based drilling fluids, has minimal impact on the viscosity of the drilling fluid system, improves the flow pattern, enhances the rock-carrying capacity and barite suspension stability of oil-based drilling fluids, and is more beneficial for field operations.
Owner:SINOPEC OILFIELD SERVICE CORPORATION +2

Aluminothermic flame cutting agent as well as preparation method and application thereof

The invention belongs to the technical field of flame cutting agents, and particularly relates to an aluminothermic flame cutting agent as well as a preparation method and application thereof. The thermit type flame cutting agent is prepared from the following raw materials in percentage by weight: 28.85 wt% of aluminum powder, 41.15 wt%-61.15 wt% of ferric oxide powder, 5 wt%-15 wt% of copper oxide powder and 5 wt%-15 wt% of bismuth oxide powder, wherein the sum of the weight percentages of the raw materials is 100%. By compounding the copper oxide powder and the bismuth oxide powder in a traditional thermit type cutting agent Al / Fe2O3 system, the obtained thermit type flame cutting agent has the characteristics of high combustion temperature, high gas yield, high combustion rate and low melting point, and overcomes the technical defects of the traditional thermit type cutting agent Al / Fe2O3 system; and the problems of low structural strength and low energy release efficiency caused by poor component contact in the prior art are solved.
Owner:NORTHWESTERN POLYTECHNICAL UNIV +1

A solid-free anti-collapse drilling fluid

The present invention discloses a non-solid phase anti-collapse drilling fluid, comprising: a plugging and anti-collapse inhibitor, a stabilizer, a viscosity enhancing and shearing agent, a reservoir bridging agent, a fluid loss reducer, a weighting agent, a lubricant and water. The plugging and anti-collapse inhibitor has a particle size distribution between 50 and 310 nm, can effectively plug nano-sized pores in the mud shale layer well wall, inhibit the surface hydration of clay minerals, thereby effectively stabilizing the well wall and preventing collapse, and the preparation method thereof is reliable in principle and has broad market prospects; the non-solid phase anti-collapse drilling fluid of the present invention has good performance in terms of rheology, inhibition and plugging under mud shale formation conditions.
Owner:HAINAN BRANCH OF CHINA NATIONAL OFFSHORE OIL (CHINA) CO LTD +1

Low solid phase high temperature resistant formate drilling and completion fluid and preparation method thereof

The present invention belongs to the field of oil drilling exploration and development, and relates to a high-temperature resistant low-solid composite formate drilling and completion fluid and a preparation method thereof. The low-solid-phase high-temperature resistant formate drilling and completion fluid of the present invention comprises water, a high-temperature resistant shearing agent, a high-temperature resistant filtrate reducer, a buffer, a high-temperature resistant acid-soluble plugging agent and a weighting agent. The low-solid-phase high-temperature resistant drilling and completion fluid of the present invention has the characteristics of high density, low solid phase, high temperature resistance and a wide range of applications, and can be widely used in high-temperature and high-pressure deep well exploration and development where the production layer is blocked due to leakage.
Owner:CHINA PETROLEUM & CHEMICAL CORP +1

Pyrazole-based inhibitors of DNA-dependent protein kinase and compositions and applications in gene editing

The present disclosure is directed to DNA-PK inhibitors having the Formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, prodrug, or tautomer thereof, methods of preparing the forgoing, and compositions thereof, as well as methods of use for the compounds of Formula (I), in combination with a DNA cutting agent.
Owner:JUNO THERAPEUTICS INC

Cutting agents, their preparation methods and applications, and oil-based drilling fluids

PendingCN122302268AThermodynamicsOil drilling
This invention relates to the fields of petroleum drilling technology and chemical technology, specifically to a cutting agent, its preparation method and application, and an oil-based drilling fluid. The cutting agent comprises: structural unit A provided by a polyfatty acid as shown in formula (I), structural unit B provided by a polyetheramine, and structural unit C provided by an alkanolamine compound; formula (I), in which R1 and R2 are each independently selected from H or Cl-C. 18 The alkyl group, m is a natural number greater than 1. The cutting agent in this invention has temperature-responsive characteristics, that is, the cutting performance of the cutting agent is different at different temperatures, and it can achieve the effect of cutting at high temperature and not thickening at low temperature; in addition, the cutting agent also has high temperature resistance.
Owner:CHINA NAT PETROLEUM CORP +1

High-temperature-resistant completion fluid viscosity-shear improving agent based on covalent bond-secondary bond double bond cooperation and preparation method of high-temperature-resistant completion fluid viscosity-shear improving agent

The invention discloses a high-temperature-resistant well completion fluid viscosity-shear improving agent based on covalent bond-secondary bond double bond cooperation and a preparation method of the high-temperature-resistant well completion fluid viscosity-shear improving agent, and belongs to the technical field of oil and gas resource exploration. On one hand, the viscosity and shear improving agent can form a new methylene bridge covalent bond crosslinking point, and on the other hand, the viscosity and shear improving agent can form a supramolecular association system through intermolecular hydrogen-bond interaction, and a structural system of an effective suspension stable high-density solid phase weighting agent can be formed without ultra-high molecular weight. The improvement of the crosslinking degree can effectively counteract the thermal degradation effect of high temperature on the polymer, and the high-pressure environment of the deep well can obviously enhance the stability of hydrogen bonds, so that the polymer body and a supramolecular association system formed by the polymer body are not easily damaged by the high-temperature effect, and the viscosity and cutting improving performance of the polymer in the completion fluid is further ensured.
Owner:CHINA NAT PETROLEUM CORP +1

Method for manufacturing metal material for dumbbell by utilizing metallurgical solid waste

The invention relates to the technical field of powder metallurgy, and provides a method for manufacturing a metal material for a dumbbell by utilizing metallurgical solid waste, which comprises the following steps: S1, uniformly mixing initial raw materials to obtain a mixture; and S2, the mixture is subjected to compression molding and then sintered, and the metal material for the dumbbell is obtained, the initial raw materials comprise the following raw materials in parts by weight: 70-80 parts of pig iron powder, 20-30 parts of wrought iron powder, 0.45-0.55 part of a lubricant, 0.3-0.6 part of modified graphite and 0.4-0.6 part of a cutting agent; wherein the modified graphite is obtained by modifying graphite with 6-hydroxy-2-naphthyl methyl ester. Through the technical scheme, the problem of low hardness of metal materials for dumbbells in related technologies is solved.
Owner:HEBEI JINMO SPORTS GOODS CO LTD

An adsorbent, its preparation method and application, and a method for carbon dioxide hydration adsorption

The present invention belongs to the field of carbon dioxide capture, and relates to an adsorbent, a preparation method and application thereof, and a method for carbon dioxide hydration adsorption. The preparation method of the adsorbent comprises the following steps: S1. Hydrothermally reacting graphene oxide and a nitrogen-containing compound in water, and the conditions of the hydrothermal reaction enable the graphene oxide to be nitrogen-doped and cut into quantum dots to obtain nitrogen-doped graphene oxide quantum dots; S2. Mixing the nitrogen-doped graphene oxide quantum dots, tetrabutylammonium fluoride and cyclopentane to obtain the adsorbent. The key of the present invention lies in using a nitrogen-containing compound as a cutting agent and a doping agent to prepare graphene oxide quantum dots. On this basis, the obtained nitrogen-doped graphene oxide quantum dots are used in combination with tetrabutylammonium fluoride and cyclopentane as a carbon dioxide hydration adsorbent, which can effectively improve the separation efficiency of carbon dioxide.
Owner:XIAMEN UNIV +1

Curing material for thin uniform-thickness solidified soil diaphragm wall and construction method

The invention discloses a curing material for a thin equal-thickness cured soil diaphragm wall, the curing material comprises 60-80% of a cutting agent and 20-40% of a curing agent, the cutting agent is obtained by uniformly mixing 20-50 parts of an anti-permeability component, 3-8 parts of a drag reduction component, 600-800 parts of a low-activity filler component, 5-12 parts of a water reduction component and 0-150 parts of a dispersion component; the curing agent is obtained by uniformly mixing 50-100 parts of a gelling component, 200-400 parts of a medium-high activity component, 10-20 parts of an excitation component, 2-5 parts of a water reducing component and 0-2 parts of a defoaming component. The invention further provides a construction method of the stabilized soil diaphragm wall, the cutting agent and the curing agent are both added into the soil body in the form of slurry, the cutting agent is firstly used for secondary cutting and stirring, then the curing agent is used for stirring and curing to form the wall, and the thickness of the stabilized soil diaphragm wall can reach 300-500 mm. Through wide improvement of curing materials, the construction thickness and the water adding amount of the cured soil diaphragm wall are reduced, the anti-seepage performance, the curing strength and the construction efficiency of the diaphragm wall are improved, and the economical efficiency and the safety of the diaphragm wall are greatly improved.
Owner:TIANJIN ZHONGYAN DADI MATERIAL TECH CO LTD +5

A high-efficiency, ultra-high temperature-resistant, rock-carrying water-based drilling fluid

This invention provides a high-efficiency, ultra-high temperature-resistant, rock-carrying water-based drilling fluid. The water-based drilling fluid includes a cutting agent and a filtration loss reducer. The cutting agent is made from sepiolite and silica. This water-based drilling fluid exhibits excellent rheological properties and superior filtration loss reduction capabilities, meeting the requirements for reducing filtration loss under ultra-high temperature conditions. This satisfies the needs of drilling in ultra-high temperature formations and is of great significance for the development of hot dry rock.
Owner:PETROCHINA CO LTD +1

Ultrahigh-temperature-resistant efficient rock-carrying water-based drilling fluid

The invention provides an ultrahigh-temperature-resistant efficient rock-carrying water-based drilling fluid, the water-based drilling fluid comprises a shear strength improving agent and a filtrate reducer, and the shear strength improving agent is prepared from sepiolite and silicon dioxide. The water-based drilling fluid has good rheological property and excellent filtrate loss reduction capacity, can meet the requirement for reducing the filtrate loss under the ultrahigh-temperature condition, meets the requirement for ultrahigh-temperature formation drilling, and has important significance on development of hot dry rocks.
Owner:PETROCHINA CO LTD +1

Preparation method and application of ultra-microporous COF membrane with adjustable pore channel structure

The invention belongs to the technical field of covalent organic framework membrane materials, discloses a preparation method of an aperture-adjustable ultra-microporous membrane constructed on the basis of ethynyl functionalized COF, and explores application of the aperture-adjustable ultra-microporous membrane in ion separation. The method comprises the following steps: firstly, constructing a COF membrane with an alkynyl structure by adopting a liquid-liquid interfacial polymerization mode, and then realizing precise cutting and functional modification of a COF pore channel structure through a copper-catalyzed azide-alkynyl cycloaddition reaction, so as to obtain the ultra-microporous COF membrane with adjustable pore diameter. By selecting azidation cutting agents with different structures, flexible regulation and control on the pore diameter structure of the membrane can be realized, and the separation selectivity on lithium and magnesium ions is remarkably improved. According to the membrane structure, the diffusion rate of magnesium ions is effectively reduced and the flux and selectivity of lithium ions are improved while the original frame crystallinity is maintained. The prepared cutting type COF film has good crystallinity, a uniform film surface structure and controllable aperture adjusting capability. The method is easy and convenient to operate, mild in condition and wide in application range, and the obtained membrane material has high stability and high selectivity and has good application prospects in efficient lithium extraction and separation of salt lake water resources with the high magnesium-lithium ratio.
Owner:CHINA THREE GORGES UNIV

Cleaning method for automobile gear parts

The invention discloses a cleaning method for automobile gear parts. The cleaning method comprises the steps that S1, the automobile gear parts are placed in a first tank containing a reagent 1 to be cleaned; s2, the part is transferred into a second tank containing a reagent 2 to be cleaned; s3, the parts are transferred into a third tank containing water to be cleaned; s4, the part is transferred into a fourth tank containing a hydrocarbon water cutting agent to be soaked; s5, the part is transferred into a fifth tank containing a hydrocarbon cleaning agent B to be cleaned; s6, the part is transferred into a sixth groove containing a hydrocarbon cleaning agent B to be cleaned; s7, the parts are transferred into a seventh tank to be subjected to vacuum steam cleaning; the reagent 1 is composed of a semi-water-based cleaning agent A and water in a mass ratio of (48-52): (48-52); the reagent 2 is composed of a semi-water-based cleaning agent A and water in a mass ratio of (5-10): (90-95); according to the method, efficient cleaning is achieved by improving the formula of a semi-water-based cleaning agent A and adopting a multi-stage cleaning process, and the appearance white spot reject ratio of gear products is controlled to be lower than 1%.
Owner:GUANGDONG SUN GLOBE CLEANING TECH CO LTD

Inertial navigation metal part heat treatment dehydration device and method based on water cutting agent

The invention relates to a part dehydration device, in particular to an inertial navigation metal part heat treatment dehydration device and method based on a water cutting agent, and aims to solve the problems that the water cutting agent and water are difficult to separate and a used container is not beneficial to discharge and replacement of the water cutting agent when a water cutting agent dehydration method is adopted in the prior art. The included angle theta between the bottom surface of the dewatering box body and the horizontal plane is more than or equal to 10 degrees and less than or equal to 20 degrees; a partition plate connected with the side wall and parallel to the horizontal plane is arranged in the dewatering box body, and the height of the partition plate is equal to that of the highest position of the bottom surface of the dewatering box body; a space defined by the lower surface of the partition plate, the upper surface of the bottom surface of the dewatering box body and the inner side wall of the dewatering box body forms a water storage space; the side wall of the water storage space is provided with a water drainage port with a water drainage valve and an observation pipe, and the observation pipe is used for observing the position of the interface of water and the water cutting agent in the water storage space.
Owner:XIAN AEROSPACE PRECISION ELECTROMECHANICAL INST

Bridged cycle-based inhibitors of DNA-dependent protein kinase and compositions and application in gene editing

The present disclosure is directed to DNA-PK inhibitors having the Formula (I),or a pharmaceutically acceptable salt, stereoisomer, solvate, prodrug, or tautomer thereof, methods of preparing the foregoing, and compositions thereof, as well as methods of use for the compounds of Formula (I), in combination with a DNA cutting agent.
Owner:JUNO THERAPEUTICS INC

Method for separating plurality of slices from workpiece during separation process by means of wire saw

The invention relates to a method for separating a plurality of pieces from a workpiece (2) during a separating process by means of a wire saw, the wire saw comprising a control mechanism and a wire web formed by moving sections of the wire saw, and the wire web being clamped in a plane between two wire guide rollers, wherein each of the two wire guide rollers is mounted between a fixed bearing and a floating bearing, wherein the method comprises: feeding a workpiece (2) through the wire mesh by means of a control mechanism in a feeding direction perpendicular to the workpiece axis and perpendicular to the plane of the wire mesh; supplying a cutting agent to the wire mesh; supplying a temperature control medium to the workpiece; guiding a temperature control liquid through the fixed bearing according to a temperature curve and / or displacing the workpiece along the workpiece axis according to a displacement curve, wherein the temperature curve and the displacement curve counteract the shape deviation; the method is characterized in that the warpage curve of at least one wafer from the starting end (3) of the workpiece and at least one wafer from the tail end (4) of the workpiece in at least one previous separation process using the wire saw is determined; generating a difference value between the warping curves; setting the temperature and / or the volume flow rate of the cutting agent during the separation process according to the difference between the warpage curves; and setting the temperature and / or volume flow rate of a temperature control medium according to the difference between the warping curves.
Owner:SILTRONIC AG

High-performance ultra-low-temperature drilling fluid system, preparation method and application thereof

The application provides a high-performance ultra-low-temperature drilling fluid system and a preparation method and application thereof.The drilling fluid system comprises the following components in mass fraction: base fluid 80-90 parts, cutting agent 2-4 parts, flow pattern regulator 2-3 parts, wetting agent 1-2 parts and weighting agent 10-20 parts; wherein the preparation method of the wetting agent comprises the following steps: uniformly mixing polyoxyethylene ether and sodium fatty acid methyl ester sulfonate, heating, adding a catalyst, and then obtaining the wetting agent through reaction.The ultra-low-temperature drilling fluid system has excellent rheological properties and colloid dispersion properties under ultra-low-temperature conditions, and has excellent ultra-low-temperature resistance.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)