204 results about "Acepyrylene" patented technology

The invention relates to a crystalline hydrate of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene and to crystalline complexes between 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene and a natural amino acid, to methods for the preparation thereof, as well as to uses thereof for preparing medicaments.

The present invention relates, inter alia, to compounds having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —NC4H8, —NC5H10, —NC4H8O, —CHO, —CH(OH)CH3, —C(O)CH3, —O(CH2)2N(CH3)2, and —O(CH2)2NC5H10; R2 is a member selected from the group consisting of hydrogen, halogen, alkyl, acyl, hydroxy, alkoxy (e.g., methoxy, ethoxy, vinyloxy, ethynyloxy, cyclopropyloxy, etc.), acyloxy (e.g., acetoxy, glycinate, etc.), alkylcarbonate, cypionyloxy, S-alkyl, —SCN, S-acyl and —OC(O)R6, wherein R6 is a functional group including, but not limited to, alkyl (e.g., methyl, ethyl, etc.), alkoxy ester (e.g., —CH2OCH3) and alkoxy (—OCH3); R3 is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R4 is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ═O and ═N—OR5, wherein R5 is a member selected from the group consisting of hydrogen and alkyl.In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat meningiomas; to treat uterine leiomyomas; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce cervical ripening; to induce labor; and for contraception.

Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. The reactions may be performed in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and / or Sharpless-Huisgen reactions Novel 3-substituted cyclopropene compounds and trans-cyclooctenes are exemplary dienophiles for these reactions.

The present invention relates to a new industrial process for the synthesis of solvate- free 17a-acetoxy-11ss-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB -2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process. The process according to the invention is the following: i) 3-(ethylene-dioxy)-estra-5(10),9(11)-diene-17-one of formula (X) is reacted with potassium acetilyde formed in situ in dry tetrahydrofuran by known method, ii) the obtained 3-(ethylene-dioxy)-17a-ethynyl-17ss-hydroxy-estra-5(10),9(11)-diene of formula (IX) is reacted with phenylsulfenyl chloride in dichloromethane in the presence of triethylamine and acetic acid, iii) the obtained isomeric mixture of 3-(ethylene-dioxy)-21-(phenyl-sulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene of formula (VIII) is reacted first with sodium methoxide in methanol, then with trimethyl phosphite, iv) the obtained 3-(ethylene-dioxy)-17a-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene of formula (VII) is reacted with hydrogen chloride in methanol, then v) the obtained 3-(ethylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11l); -diene-20- one of formula (VI) is reacted with ethylene glycol hi dichloromethane in the presence of trimethyl orthoformate and p-toluenesulfonic acid by known method, vi) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-19-norpregna- 5(10),9(11)-diene of formula (V) is reacted with hydrogen peroxide in a mixture of pyridine and dichloromethane in the presence of hexachloroacetone by known method, vii) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-5,10-epoxy-19-norpregn-9(11)-ene of formula (IV), containing approximately a 1:1 mixture of 5a,10a- and 5ss,10ss-epoxides, is isolated from the solution and reacted with a Grignard reagent obtained from 4-bromo-N,N-dimethyl-aniline in tetrahydrofuran.

The present invention relates to novel acetylenedicarboxyl linkers used for the specific conjugation of compounds / cytotoxic agents to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

The invention relates to a modified nanoparticle including a nanoparticle and a diblock copolymer covalently attached to the nanoparticle, the diblock copolymer comprising a first block polymer of molecular weight greater than 1000 attached to the nanoparticle and a second block polymer of molecular weight greater than 1000 covalently linked to the first block polymer, wherein at least one of the first block polymer and second block polymer comprises repeating units having an azide, acetylene or triazole side chain. Nanocomposites incorporating modified nanoparticles, as well as methods of making modified nanoparticles and nanocomposites are also disclosed.

The invention discloses a supported ruthenium complex catalyst. The supported ruthenium complex catalyst comprises a porous solid carrier, and a ruthenium complex, a metal assistant and a nonmetal assistant which are supported on the surface of the carrier, and the ruthenium complex is one or more of a polypyridine ruthenium complex, a ruthenium porphyrin ruthenium complex, an aromatic hydrocarbonruthenium complex, a cyclic metal ruthenium complex, a DMSO ruthenium complex, an amine ruthenium complex and an imine ruthenium complex; the metal assistant is salt of one or more of In, Bi, Ba, Sr,Fe, Mn, Zn, Cs, Ca and Sn; the nonmetal assistant is an ionic liquid; and a ratio of the mass of the porous solid carrier to the theoretic mass of ruthenium in the ruthenium complex to the mass of the metal in the metal assistant to the mass of the nonmetal assistant is 100:(0.01-2):(0.01-3):(1-30). The catalyst has a very high stability in an acetylene hydrochlorination reaction, no obvious lossof the ruthenium is detected after the catalyst runs for 8000 h, the highest acetylene conversion rate reaches 99.95% or more, and the highest vinyl chloride selectivity reaches 99.95% or more.

The present invention is a method of cleaning to removal residue in semiconductor manufacturing processing, comprising contacting a surface to be cleaned with an aqueous formulation having a polymer selected from the group consisting of acrylamido-methyl-propane sulfonate) polymers, acrylic acid-2-acrylamido-2-methylpropane sulfonic acid copolymer and mixtures thereof and a quaternary ammonium hydroxide having greater than 4 carbon atoms or choline hydroxide with a non-acetylinic surfactant.The present invention is also a post-CMP cleaning formulation having the components set forth in the method above.

The invention discloses a substituted crotonamide maleate, a crystal form thereof, a method for preparing all crystal forms of crystallized maleate, relevant compounds, and a medicinal composition including the compounds. (E)-N-{4-[3-acetylenylphenylamino]-3-cyan-7-ethoxy-6-quinolyl}}-4(dimethylamino)-2-crotonamide maleate, a crystal form I, a crystal form II or a crystal form III respectively have EGFR or ErbB2 kinase inhibition activity, can be used to prevent, treat or inhibit tumors, and can be especially to prepare drugs for preventing, treating or inhibiting epidermal growth factor receptor family related tumors.

Ink for inkjet textile printing of the present invention contains water, a disperse dye, a water-soluble organic solvent and an anionic high-molecular dispersant. The water-soluble organic solvent is a polyhydric alcohol such as glycerin. The water-soluble organic solvent is contained in an amount of 25 to 50 mass % with respect to the total mass of the ink. The anionic high-molecular dispersant is a styrene-(meth)acrylic acid-based copolymer having an acid value of 160 to 250 mg KOH / g and a weight-average molecular weight of 8,000 to 20,000. The ink for inkjet textile printing further contains an acetylene glycol-based compound expressed by the following Chemical Formula (I) as a penetrant. With this ink for inkjet textile printing, provided is disperse dye-containing ink for inkjet textile printing that has a high-quality and stable recording performance and achieves a high print density on the surface of a fabric while maintaining an ink storage stability, and an inkjet textile printing method using the ink for inkjet textile printing.

The invention discloses a nitrogen-doped activated carbon catalyst and application thereof. The preparation method of the nitrogen-doped activated carbon catalyst comprises the following steps: adding a nitrogen-containing compound into water to dissolve to obtain a nitride solution, wherein the nitrogen-containing compound is one or more of ammonia water, ammonia gas, pyridine, pyrrole, imidazole, acrylamide, polyacrylamide and polyvinylpyrrolidone; adding activated carbon into the nitride solution to soak; completely drying the soaked activated carbon, and calcining in nitrogen atmosphere, thereby preparing the nitrogen-doped activated carbon catalyst. The nitrogen-doped activated carbon catalyst disclosed by the invention has very good catalysis property in reaction of catalyzing tetrachloroethane and acetylene to generate trichloro ethylene and chloroethylene and catalyzing tetrachloroethane gas phase cracking to generate trichloro ethylene.

Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 2-methylene-19-nor-20(S)-1α-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene-1α,25-dihydroxyvitamin D3, 2-methylene-1α,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D3, 2-methylene-19-nor-(24R)-1α,25-dihydroxyvitamin D2, 2-methylene-(20R,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, 2-methylene-19-nor-1α-hydroxy-pregnacalciferol, 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20R)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-19-nor-(20S)-1α-hydroxy-trishomopregnacalciferol, 2-methylene-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnancalciferol, (2-(3′hydroxypropyl-1′,2′-idene)-19,23,24-trinor-(20S)-1α-hydroxyvitamin D3, 2-methylene-18,19-dinor-(20S)-1α,25-dihydroxyvitamin D3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and / or a solute thereof. Compounds that activate retinoic acid receptors, such as retinoyls and retinoyl esters, include 13-cis-retinoic acid, all-trans-retinoic acid, (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexeneyl)nona-2,4,6,8-tetraenoic acid, 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid, 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-napthoic acid, 4-[1-(3,5,5,8,8-pentamethyl-tetralin-2-yl)ethenyl]benzoic acid, retinobenzoic acid, ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate, retinoyl t-butyrate, retinoyl pinacol, retinoyl cholesterol, an isomer thereof, a prodrug thereof for oral compositions, an ester thereof, a salt thereof, and / or, a solute thereof. Combinations of such active ingredients demonstrate synergistic efficacy.

The present invention discloses an improved and novel process for the preparation of erlotinib (N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine) of formula (1), which comprises: (i) demethylation of commercially available 6,7-dimethoxy-4(3H)-quinazolinone of formula (8); acetylation using acetic anhydride; (iii) introduction of a leaving group at C-4 position in quinazolinone; (iv) condensation with 3-ethynylaniline to get novel compound of formula (12); (v) deacetylation to get novel dihydroxy compound of formula (13); and (vi) O-alkylation with 2-iodoethylmethyl ether to get the erlotinib base of formula (1). Erlotinib base is purified by recrystallization from ethyl acetate to get a HPLC purity of >99.5%. Salt formation of this base with hydrogen chloride gave pharmaceutically acceptable erlotinib hydrochloride of formula (1a) with a HPLC purity of >99.8%. Erlotinib hydrochloride is useful for the treatment of proliferative disorders, such as cancers, in humans.

The invention relates to a semi-conductive internal shielding material composition. The composition contains an ethylene-butyl acrylate copolymer, an ethylene-vinyl acetate copolymer, an antioxidant, a cross-linking agent, a dispersant, lubricating oil, an anti-copper agent and acetylene carbon black, wherein relative to 100 parts by weight of ethylene-acrylate, the content of the ethylene-vinyl acetate copolymer is 50-65 parts by weight, the content of the acetylene carbon black is 50-72 parts by weight, the content of the antioxidant is 0.1-1.5 parts by weight, the content of the cross-linking agent is 0.5-2.5 parts by weight, the content of the dispersant is 1-10 parts by weight, the content of the lubricating oil is 1-12 parts by weight, and the content of the anti-copper agent is 0.05-1.2 parts by weight. The invention further relates to a semi-conductive internal shielding material for a medium and low-pressure and 110KV cable and a manufacturing method thereof, as well as the medium and low-pressure and 110KV cable. When the semi-conductive internal shielding material provided by the invention is used for extruding the cable, and the phenomenon of scorching can be avoided.

The present invention relates to one kind of polyfluoro substituted diphenyl acetylene derivative and its composition, preparation process and use as the liquid crystal material for display. The polyfluoro substituted diphenyl acetylene derivative has the general expression as shown, great optical anisotropy, relatively low viscosity, relatively wide nematic phase temperature range, excellent low temperature compatibility, facile material, and simple and feasible synthetic path, and is suitable for use as displaying liquid crystal material with improved response speed and driving voltage. The liquid crystal composition has excellent performance, including greatly improved response speed and low temperature compatibility, and may be used in liquid crystal display of TN mode, STN mode, TFT mode, etc.

The invention discloses a deuterated acetylenic derivative, a pharmaceutical composition and application thereof. The deuterated acetylenic derivative comprises one or more of the deuterated acetylenic derivative (I) with curative effective dose, pharmaceutically-acceptable salt, a stereoisomer, solvate, a polymorphic substance, tautomer, metabolite and prodrugs thereof and at least one pharmaceutically-acceptable auxiliary material. The invention also provides the deuterated acetylenic derivative (I), the pharmaceutically-acceptable salt, the stereoisomer, the solvate, the polymorphic substance, the tautomer, the metabolite or the prodrug thereof, or application of the pharmaceutical composition in preparing one or more protein kinase inhibitors and application in preparing drugs for treating and / or preventing tumors. The deuterated acetylenic derivative (I) disclosed by the invention has the advantages that the activity of protein kinase and the growth of tumor cells can be effectively inhibited, and excellent pharmacokinetic properties and in-vitro and in-vivo pharmaceutical effect are expressed. The formula (I) is as shown in the specification.

The invention relates to a method for preparing a super capacitor on the basis of a three-dimensional porous graphene composite material. The method comprises the following steps of grinding and mixing the three-dimensional porous graphene composite material, acetylene black and a polytetrafluoroethylene emulsion with the mass fraction of 15 percent in the weight part ratio of (76-84):(12-18): (5-8) into electrode slurry, and uniformly dispersing the electrode slurry into a small amount of anhydrous alcohol to form paste liquid, and coating the paste liquid onto the surface of foam nickel to form a thin sheet to obtain an electrode plate; taking a polypropylene porous film as a septum, soaking the septum in electrolyte aqueous solution, placing the soaked septum between two electrode plates, and packaging to prepare the super capacitor of the two electrode plates. The method is based on the three-dimensional porous graphene composite material; when the packaging current density is 0.1 A / g, the specific capacity can be between 236 and 160f / g.

The invention discloses a method for continuously preparing a 2-aryl-benzothiophene / furan compound by utilizing an electrochemical micro-channel reaction device. The preparation method comprises the following steps: dissolving ethynyl thioanisole / phenylethynyl anisole and an iodine-containing electrolyte in water and acetonitrile to prepare a homogeneous solution, then introducing the prepared homogeneous solution into a feeding hole of an electrochemical micro-channel reaction device by utilizing an injection pump in single-strand sample introduction, and reacting under the action of a direct-current power supply to obtain the product 2-aryl-benzothiophene / furan compound; wherein the electrochemical micro-channel reaction device comprises an anode electrode, a cathode electrode, an electrolytic tank bracket, a reaction tank, the direct-current power supply and a temperature control module; wherein the reaction tank is positioned between the anode electrode and the cathode electrode, and a closed serpentine flow path is formed between the anode electrode and the cathode electrode; the anode electrode and the cathode electrode are arranged on the electrolytic tank bracket; one endsof the anode electrode and the cathode electrode are connected with each other and are connected with the direct-current power supply; and the temperature control module is embedded in the electrolytic tank bracket and is used for controlling the temperature of liquid in the reaction tank.

The invention belongs to the field of conjugated polymers, and discloses a fluorescent conjugated polymer containing a phenothiazine group, and a synthesis method and an application thereof. The synthesis method comprises the following steps: firstly, synthesizing an N-alkyl-3,6-bi(acetenyl) phenothiazine monomer, then completely dissolving the N-alkyl-3,6-bi(acetenyl) phenothiazine monomer and an N-octyl-3,6-bi(acetenyl) carbazole monomer or a 4,7-diacetenyl-2,1,3-benzothiazine oxazole monomer into orthodichlorobenzene, and carrying out reaction under stirring in a catalytic system containing CuCl and TMEDA; precipitating and filtering the mixture in a mixed solution of methyl alcohol and concentrated hydrochloric acid after reaction is ended, and carrying out vacuum drying, so as to obtain the fluorescent conjugated polymer containing the phenothiazine group. According to the fluorescent conjugated polymer, the solubility of the polymer is improved by introducing an alkyl chain into the phenothiazine group, the structure is improved by introducing groups with different electron donating and withdrawing effects, and the conjugated polymer with excellent photoelectric property, solubility and heat stability is provided.

The invention belongs to the field of coating, and discloses a quickly-dried oily osmosis film forming type nano composite protective agent, as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing methylsilicone oil with high hydrogen content, long-chain alkyl acrylic ester, a platinum catalyst and an inert anhydrous solvent, performing reaction under the temperature of 70-90 DEG C for 2-6 hours, performing cooling, adding acetenyl cyclohexanol serving as an inhibitor, and naturally volatilizing to remove the solvent so as to prepare long-chain alkyl modified polymethylsiloxane containing active silicon hydrogen keys; then diluting the long-chain alkyl modified polymethylsiloxane containing the active silicon hydrogen keys by the inert anhydrous solvent, then adding nano MQ silicon resin, a silane coupling agent and a titanate coupling agent for uniform mixing to obtain a mixture, and diluting the mixture by the inert anhydrous solvent until the effective mass content is 1-10 percent so as to obtain the quickly-dried oily osmosis film forming type nano composite protective agent. The surface of an inorganic multihole base material is coated with the product, so that excellent osmosis film forming property and quick dryness are achieved; the quickly-dried oily osmosis film forming type nano composite protective agent is high in antifouling property and acid-alkali resistance performance.

The invention relates to a preparation method of microporous conjugated polymer carbide lithium ion battery anode material. The method comprises the steps of: firstly, carrying out self-coupling polymerization reaction on alkynyl at the tail end of a monomer catalyzed by Pd (II) / Cu (I), and polymerizing 1, 3, 5-tri-acetenyl benzene to obtain microporous conjugated polymer with a rigid three-dimensional network structure; or carrying out coupling copolymerization reaction on the alkynyl at the tail end of a monomer catalyzed by Pd (II) and Sonogashira-Hagihara with a halogenated group, and polymerizing acetenyl aromatic compound monomer and halogenated aromatic compound monomer to obtain the microporous conjugated polymer; then, carrying out pretreatment on precursor mixture in weak reductive inert atmosphere at the high temperature of 200-400 DEG C for 1-5h to carbonize the microporous conjugated polymer in advance; heating up to 600-800 DEG C, and carrying out heat preservation for 2-10h to fully carbonize the microporous conjugated polymer; and cooling to the room temperature to obtain the target product microporous conjugated polymer carbide anode material.

PCT No. PCT / US96 / 14967 Sec. 371 Date Sep. 11, 1998 Sec. 102(e) Date Sep. 11, 1998 PCT Filed Sep. 18, 1996 PCT Pub. No. WO97 / 11097 PCT Pub. Date Mar. 27, 1997Polypropylene is crosslinked by means of an ionizing radiation followed by annealing at a temperature of at least 110 DEG C., in the presence of an unsaturated monomeric compound such as acetylene or 1,3-butadiene or 1,3,5-hexatriene.

The invention provides a preparation method of a high-performance polyimide film. The method comprises the following steps: in an inert atmosphere, adding diamine POSS, ethynyl-containing diamine andfluorine-containing diamine into a phenolic solvent; after dissolving of the above substances, adding rigid and straight dianhydride and twisted dianhydride; carrying out reacting, then adding ethynyl-containing monoamine; performing imidization by adopting a one-step method or a two-step method; pouring the obtained polyimide resin solution into a precipitant for precipitation; dissolving a precipitate obtained in the previous step in an amide solvent to obtain a glue solution; and subjecting the glue solution to tape casting on a stainless steel plate, and performing gradient heating to obtain the high-performance polyimide film. According to the method, ethynyl functional group-containing diamine is introduced into the middle part of a molecular chain structure, monoamine with an acetenyl group is introduced to the tail end of a molecular chain, cross-linking curing is achieved through a cage structure of diamine POSS and an acetenyl group at a certain temperature, a network-shapedmolecular structure is formed, and the solvent resistance, the mechanical property and the heat resistance of the transparent polyimide film are comprehensively improved.

Provided is a composition that enhances the effects of monosaccharides. The composition is a composition comprising a monosaccharide as an active ingredient thereof and comprising at least one or more assistants selected from a nonionic surfactant (excluding acetylene glycol-based surfactants, fluorine-based surfactants and silicone-based surfactants), an anionic surfactant (excluding lignin sulfonate), a cationic surfactant, an amphoteric surfactant, a water-soluble polymer, an amino acid, an amino sugar, a disaccharide alcohol and a salt, and is effective as an agricultural control composition against plant disease, particularly plant disease caused by fungi and plant disease caused by bacteria.

The invention discloses a method for continuously preparing 2-aryl-3-halogenated-benzofuran compounds by using an electrochemical microchannel reaction device. The method for preparing benzofuran compounds comprises dissolving ethynyl anisole and electrolyte containing iodine or bromine in water and acetonitrile to prepare a homogeneous solution, then introducing the prepared homogeneous solutioninto the feed port of the electrochemical microchannel reaction device by a syringe pump in single feeding way, and reacting under the action of a DC power supply to obtain the product 2-aryl-3-halogenated-benzofuran compounds; wherein the electrochemical microchannel reaction device comprises an anode electrode, a cathode electrode, an electrolytic cell support, a reaction tank, a DC power supplyand a temperature control module; the reaction tank is located between the anode electrode and the cathode electrode, and a closed serpentine flow path is formed between the anode electrode and the cathode electrode; the anode electrode and the cathode electrode are installed on the electrolytic cell bracket; one ends of the anode electrode and the cathode electrode are connected with each otherand is connected with a DC power supply; the temperature control module is embedded in the electrolytic cell bracket and is used for controlling the temperature of the liquid in the reaction tank.

A surfactant composition is provided. The composition comprises (A) an acetylenediol ethoxylate capped by a glycidyl ether represented by the following structural formula (I):wherein R1 is hydrogen atom, or a C1-6 straight chain, branched or cyclic alkyl group, R2 is a C1-12 straight chain, branched or cyclic alkyl group, R3 is —CH2OR4, R4 is a C2-30 straight chain, branched or cyclic alkyl group, alkenyl group, aryl group, or aralkyl group, n, m, p, and q are a positive number with the average of (n+m) being 1 to 100, and the average of (p+q) being 0.5 to 5), and (B) a silicone surfactant. The coating solution prepared by blending the surfactant composition of the present invention can be coated without causing inconsistency since it does not experience foaming when coated on the rubber article, and industrially advantageous production of a rubber article with non-sticky surface is thereby enabled.

The invention provides a conjugated microporous polymer aggregation-induced ECL sensor based on tetraphenyl ethylene and a preparation method and application thereof. According to the invention, threekinds of TPE-CMP (namely, TPE-CMP-1, TPE-CMP-2 and TPE-CMP-3) are used for researching an ECL mechanism; the advantages of a luminescence technology and an electrochemical technology are combined; and tri(4-acetenylphenyl)amine (TEPA), 4,4'-diacetenyl biphenyl (DEBP) and 2,4,6 tri(4-acetenylphenyl)-1,3,5-triazine (TEPT) are respectively prepared by using different coupling agents, and are furtherused for constructing an ECL sensor for detecting dopamine. Testing results prove that the ECL sensor has extremely high sensitivity to dopamine and can be used for analyzing biological samples, so the ECL sensor has good practical application value.

The invention provides a preparation method of an erlotinib hydrochloride crystal form A, which belongs to the technical field of the preparation of a drug compound. The preparation method comprises the following steps: enabling 2-amino-4,5-di(2-methoxy ethyoxyl) cyanophenyl and N, N-dimethyl amide dimethyl acetal to react; re-crystallizing and purifying the obtained Schiff base intermediate, and then synthesizing with aminophenylacetylene to obtain erlotinib free alkali; and adding a hydrochloric acid solution, and recrystallizing to obtain the erlotinib hydrochloride crystal form A. According to the scheme of the invention, the process route is short, the product purity is high, the repeatability is good, and the operation is simple and easy to implement, and therefore, the preparation method is suitable for large-scale industrial production.

The invention discloses a high-strength PVC (polyvinyl chloride) pipe material. The high-strength PVC pipe material comprises a PVC layer, a bonding layer and a carbon fiber cloth layer; the carbon fiber cloth layer wraps the outer part of the PVC layer through the bonding layer; a plurality of reinforced connecting grooves are formed in the surface of the outer side of the PVC layer; four reinforced ribs are horizontally arranged on the inner side of the PVC layer; the PVC layer comprises the following raw material componentsincluding, by weight,30-35 parts of PVC resin, 15-20 parts of chlorinated polyethylene, 10-15 parts of ethylene-propylene rubber, 5-8 parts of acetylene-propylene copolymer, 2-4 parts of a stabilizer, 8-12 parts of filler and 1-3 parts of beta-cyclodextrin. Through the reinforced ribs, the internal supporting strength of the PVC pipe is enhanced and use in actual life is facilitated; and through the carbon fiber cloth layer, the carbon fiber cloth layer has high strength, low density and small thickness, does not increase the self-weight of a reinforcing component and the section size, is suitable for various structure types and greatly enhances the external supporting strength of the PVC pipe.