54 results about "Acepyrylene" patented technology

The invention relates to the field of acetylene purification and new materials, and particularly provides a double-interspersed MOF (Metal Organic Framework) and a preparation method and application thereof in acetylene purification, and the specific synthesis method comprises the following steps: reacting a tricarboxylic acid ligand 1, 3, 5-tris (4-carboxylphenyl) benzene (H3btb) with a nitrogen-containing methyl-containing ligand 3-methyl-1H-1, 2, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3-tetramethyl-1 The MOF (Zn-btb-fmtrz) with ultrahigh stability performance is synthesized from 2, 3, 4-triazole (fmtrz) and a zinc-containing compound, and the material can be used as an adsorbent, has strong acetylene adsorption action force, high selectivity and good stability, is suitable for industrial production, and shows a more excellent separation effect on low-concentration acetylene compared with a traditional method. The synthesized material is stable and has good acetylene adsorption capacity, and a new direction is provided for using MOF as an acetylene purification material.

The invention relates to the technical field of prime coat copper foils, in particular to a prime coat copper foil preparation method for improving the cycle performance of a silica material, which comprises the following steps: step 1, mixing pure water and polyacrylic acid, sequentially adding acetylene black, isopropanol, LLZO and LiNO3, and uniformly stirring to obtain prime coat slurry; step 2, coating a copper foil with the prime coat slurry, and drying to obtain a prime coat copper foil; lLZO and LiNO3 are introduced into the bottom coating, so that the volume deformation of the silica material can be effectively relieved, the puncture of lithium dendrites is inhibited, and the cycle performance and safety of the battery are improved.

The invention relates to phosphine ligands and their use in the carbonylation of acetylene / ethylene for the synthesis of acrylate / propionate. The phosphine ligands according to the invention are represented by formulas I to VIII. The invention describes the use of these phosphine ligands in combination with palladium catalysts for carbonylation reactions of acetylene or ethylene for the production of acrylate or propionate compounds. The processes are characterized by high catalytic efficiency, excellent product yields, outstanding selectivity, and ease of implementation. Particular advantages include improved reaction kinetics due to the optimized ligand structures, economical process control due to high catalyst productivity, and a broad range of applications for various acrylate and propionate derivatives. The invention is particularly suitable for industrial synthesis processes in fine chemical production.

The invention belongs to the technical field of biological medicines, relates to application of a compound 1 in treatment or prevention of diseases related to RET fusion and / or RET mutation, and provides application of N (3-chloro-5 (trifluoromethyl) phenyl) 3 ((6 (4-hydroxypiperidine-1-yl) imidazo [1, 2-a] pyridin-2-yl)-1, 3, 4-triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4 The invention relates to application of (2R, 2R, 2b) pyridazin-3-yl) ethynyl) 2-methylbenzamide or pharmaceutically acceptable salts thereof in treatment or prevention of RET fusion and / or RET mutation related diseases, and application of the (2R, 2R, 2b) pyridazin-3-yl) ethynyl) 2-methylbenzamide or pharmaceutically acceptable salts thereof in treatment or prevention of RET fusion and / or RET mutation related diseases in treatment or prevention of RET fusion and / or RET mutation related diseases by utilizing broad-spectrum and efficient RET inhibition activity, excellent drug-resistant mutation covering ability and higher safety The technical problems of drug resistance, off-target toxicity, high medication frequency and the like of the existing RET inhibitor are solved, and a new effective means is provided for accurate treatment of RET-driven tumors.

The present disclosure provides a tyrosine kinase inhibitor having the general formula (I).R1 is C1-C6 alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, mono-substituted phenyl, poly-substituted phenyl, trifluoromethyl, 2,2,2-trifluoroethyl, CH3O(CH2)n-,R being methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl, cyclopropyl, acetyl or acryloyl, and n being an integer from 1 to 6. R2 and R3 are respectively halogen, hydrogen, amino, substituted amino, cyano, hydroxyl, sulfonic acid group, sulfonamide, trifluoromethyl, 2,2,2-trifluoroethyl, methyl, methoxy or ethynyl. R2 and R3 are in an ortho, para or meta position. Y is NH, O, S or Z—N, where Z is methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl or cyclopropyl. X is Cl, Br or F.

The application discloses synergistically modified ethyne carbon black by poly malic acid and KH550, a preparation method and application thereof, and the method comprises the following steps: blending poly malic acid, gamma-aminopropyl triethoxysilane and ethyne carbon black in a mass ratio of (0.5-5):(1-10):100, and then performing reaction to obtain ethyne carbon black synergistically modified by poly malic acid and gamma-aminopropyl triethoxysilane. The ethyne carbon black is synergistically modified by poly malic acid and gamma-aminopropyl triethoxysilane (KH550), an esterification reaction occurs between the carboxyl in the poly malic acid molecule and the surface hydroxyl of the ethyne carbon black, meanwhile, a hydroxylamino reaction occurs between the amino group of the KH550 and the hydroxyl, and an amide bond bridge is formed between the poly malic acid and the KH550, thereby realizing ternary synergistic covalent modification. The structure effectively improves the dispersion stability of the ethyne carbon black, the chain-like or grape-like high specific surface area structure of the ethyne carbon black can be fully utilized, the ethyne carbon black is more uniformly dispersed in a polymer matrix, and the interface is more closely combined.

The invention relates to the technical field of heating material preparation, and discloses a high-heating graphene composite material and a preparation method thereof.The preparation method comprises the steps that pretreated graphene, carbon nanotubes and acetylene black are added into an ethanol solution, a composite dispersing agent, a titanate coupling agent and a weak reducing agent are added, resin is added after dispersion, stirring is carried out, and the high-heating graphene composite material is obtained; adding nano silicon dioxide, a defoaming agent and a flatting agent, and adjusting a system to obtain heating slurry; drying, hot-pressing and cooling the heating slurry to obtain a heating film; and adhering nickel-plated copper conductive strips to the two ends of the heating film to obtain the high-heating graphene composite material. Graphene, a carbon nano tube and an acetylene black gradient conductive phase are used as a core heating body, waterborne acrylic acid and a polyurethane interpenetrating network are used as a flexible matrix, the interface bonding force of a carbon phase and the matrix is improved through in-situ modification of a titanate coupling agent, and heat conduction and heat resistance are enhanced by adding nano silicon dioxide; the finally prepared flexible self-supporting graphene heating film has high heating density, excellent flexibility and high-temperature stability.

The application belongs to the technical field of extraction separation, and particularly relates to a 3N-PTD ligand and a preparation method and application thereof. The preparation method provided by the application comprises the following steps: mixing 3-chloropropylamine hydrochloride, sodium azide and deionized water, and performing a reflux reaction to obtain 3-azidopropylamine; dissolving 2,6-diethynylpyridine, 3-azidopropylamine, sodium ascorbate and CuSO4.5H2O, and performing a click reaction to obtain the 3N-PTD ligand. The yield of the 3N-PTD ligand obtained by the preparation method is high.

This application belongs to the field of biomedical technology and discloses an aromatic acetylenyl derivative, a method for coupling it with a thiol, and its application. The aromatic acetylenyl derivative has the following formula (1), where Ar is aryl or heteroaryl; X is -NH-; Y is -(C2H4-O)m-(CH2)s-(COO)h-A; A is selected from one of halogen, C1-C6 alkyl, trifluoromethyl, hydroxyl, methoxy, trifluoromethoxy, acetoxy, cyano, nitro, amino, methylamino, dimethylamino, sulfonamide, methanesulfonyl, methanesulfonamide, carboxyl, and ester, preferably hydroxyl, C1-C6 alkyl or amino; m, s, and h are integers from 0 to 20.

The application discloses a ceramic paint for metal doors and a preparation method thereof, and relates to the technical field of paints. The ceramic paint prepared by the application contains sodium silicate, methyltrimethoxysilane, modified polyacrylate emulsion, modified silicon dioxide, glass powder, sodium fluorosilicate, dispersant, leveling agent and pure water. The modified polyacrylate emulsion is obtained by polymerizing phosphorus-containing monomers and vinyl monomers to generate polyacrylate, reacting the polyacrylate with 5-chloromethyl-2-pyrimidine amine after sulfonyl chlorination, and then emulsifying. The silicon dioxide is obtained by polymerizing aniline on the surface of pretreated silicon dioxide, reacting with 1-benzothiophene-5-carbonyl chloride, then salifying with diphenyl iodonium triflate and copper acetate, and then reacting with bis(2-ethynylphenyl) sulfane. The ceramic paint prepared by the application has good corrosion resistance, antibacterial property and anti-aging property, and greatly improves the performance of the metal door.

This invention discloses a benzoxazine-modified epoxy resin, its preparation method, and its applications. The benzoxazine-modified epoxy resin comprises the following components by weight: 40-80 parts benzoxazine resin, 20-60 parts epoxy resin, 7-22 parts curing agent, and 0-1 parts toughening agent. The high-temperature benzoxazine-modified high-temperature epoxy resin, especially benzoxazine resins containing acetylene and / or allyl groups, and bisphenol A or bisphenol F type benzoxazine resins, can be mixed with naphthalene-type epoxy resins or bisphenol F type epoxy resins containing two or more epoxy functional groups, such as tetrafunctional bisphenol F type epoxy resins. This method maintains the high-temperature resistance of the epoxy resin curing system while preserving the mechanical strength of the high-temperature epoxy resin, and significantly reduces the dielectric constant. The curing agent further enhances its mechanical properties. The preparation and curing methods of this invention are simple, the raw materials are readily available, and the cured material exhibits excellent characteristics of a high-temperature resistant, high-toughness, and low-dielectric material.

The present invention relates to the use of silylethynyl hetaryl compound as nitrification Inhibitors.

The invention discloses anti-mildew plastic for a packaging container and a preparation method of the anti-mildew plastic, and relates to the technical field of plastic. The plastic is prepared from the modified biochar and the modified polyethylene; wherein 3, 5-diformylphenylboronic acid, 5-nitro-2-(oxiranyl methoxy) acetophenone, ethynyl magnesium bromide, isobutyldichlorosilane, hydroxylamine hydrochloride, ammonium salt and 3-butenyl chloroformate are used for synthesizing an anti-aging substance, then the anti-aging substance and polyethylene are subjected to cross-linking modification, an ultraviolet absorption group, a silicon-carbon bond and a boron-carbon bond are introduced into a polyethylene side chain, and the anti-aging substance is prepared. While the photo-thermal aging of the plastic is prevented, the barrier property of the plastic is improved; the biochar is modified by aminopropyl methyl dimethoxysilane, N, N-diethyl-p-aminobenzaldehyde, 11-chlorodecanoic acid and chitosan, antibacterial groups are generated on the surface of the biochar, and the biochar and modified polyethylene can be stacked in order, so that movement of water vapor and oxygen is prevented, and the anti-mildew effect of the plastic is improved.

The application discloses acetylenic group-containing conjugated microporous polymers in a spiral structure and a preparation method thereof. A preparation process takes TNP-3Br and 1,4-diethynylbenzene or 1,3,5-triethynylbenzene as raw materials, takes tetra(triphenylphosphine palladium) and CuI as a catalyst, and takes toluene as a solvent. Through structural optimization and modular design of target CMPs, two kinds of conjugated microporous polymers CMP-1 and CMP-2 are prepared based on a Sonogashira coupling reaction mechanism by a solvothermal method. The conjugated microporous polymers have the characteristics of novel raw material structure, simple synthesis process, low cost, mild reaction condition and high yield. The synthesized CMP-1 and CMP-2 have an extended pi electron system, so that the CMP-1 and CMP-2 exhibit good electronic transmission performance. The materials have potential application values in photoelectric devices, such as organic light-emitting diodes, solar cells and the like.

This invention provides a water-based inkjet ink that exhibits excellent ejection stability, as well as superior resistance to blocking and migration of printed materials, enabling the production of high-quality printed materials even on non-permeable substrates. [Solution] An aqueous inkjet ink comprising a pigment, a surfactant (A), and a resin (R), wherein the surfactant (A) comprises an acetylenediol-based surfactant (A1) having a specific structure, a molecular weight of 400 to 650, and an HLB value of 7 to 12, and the resin (R) comprises a block resin (R1) having a glass transition temperature of 50 to 130°C and an acid value of 3 to 60 mgKOH / g, and the value expressed as AVA-AVB is 50 to 450, where AVA (mgKOH / g) is the highest acid value among the acid values ​​of each block constituting the block resin (R1) and AVB (mgKOH / g) is the lowest.

The present invention provides a laminate having excellent laminate appearance (free from streaky stains and ink loss) and laminate strength, and a method for producing the same. [Solution] A laminate having a substrate 1, a printing layer, an adhesive layer, and a substrate 2 in this order, wherein the printing layer contains an acrylic resin and a compound (A), the compound (A) contains at least one compound selected from the group consisting of an acetylene-based compound, an alcohol alkoxylate-based compound, and a siloxane-based compound, and the content of the acrylic resin is 5% by mass or more in 100% by mass of the printing layer.

The invention discloses a composite ruthenium plating solution which comprises the following components in parts by weight: 1 part of a ruthenium-containing compound precursor, 8-15 parts of an organic solvent, 0.05-0.5 part of a nano conductive enhancer, 0.01-0.06 part of a binder and 0.01-0.06 part of a flatting agent, the ruthenium-containing compound precursor is any one of ruthenium trichloride hydrate, anhydrous ruthenium trichloride or ruthenium nitrate, the organic solvent is at least one of absolute ethyl alcohol, isopropanol, n-butyl alcohol and terpilenol, and the nano conductive enhancer is at least one of graphene, carbon nanotubes and acetylene black; the binder is at least one of PVDF (Polyvinylidene Fluoride), polyvinylpyrrolidone and ethyl cellulose; the flatting agent is polyether modified polysiloxane and modified acrylate. The composite ruthenium plating solution can effectively improve the conductivity and adhesive force of a plating layer and enhance the uniformity and wear resistance of the plating layer. And a ruthenium-plated product with large capacitance, low equivalent resistance and strong binding force between a plating layer and a tantalum substrate is obtained by acting on the tantalum substrate.

The application discloses a 2-((naphthalene-2-ylmethyl)amino)acetamide compound or a pharmaceutically acceptable salt thereof with a structure as shown in formula I: wherein R 1 is H or CH3; R 2 is H or CH3; X is O, S or NH; A ring is 3-6-membered cycloalkyl, 4-6-membered heterocyclyl, aryl or heteroaryl; R 3 is H, halogen, methyl, trifluoromethyl, methoxy, cyano, nitro, vinyl or ethynyl. The compound of the application has good reversible inhibitory effect on MAOs, especially, the MAO-B inhibitory activity is significantly better than that of the third generation MAO-B inhibitor safinamide, and has reversible inhibitory effect on MAO-B, and can be used for treating neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.

The invention discloses an aryl acetylene supramolecular polymer with adjustable circular polarization luminescence, preparation and application, and relates to the technical field of circular polarization luminescent materials, and the specific preparation method comprises the following steps: reacting methyl gallate with bromododecane to obtain a compound A; reacting the compound A with sodium hydroxide to obtain a compound B; the compound B, 1-(4-bromophenyl) ethylamine, 1-ethyl-(3-dimethylaminopropyl) carbodiimide and 4-dimethylaminopyridine are subjected to a reaction, and a first intermediate is prepared; reacting the first intermediate, dichlorobis (triphenylphosphine) palladium, copper iodide and trimethylsilylacetylene to prepare a second intermediate; reacting the second intermediate, dichlorobis (triphenylphosphine) palladium, copper iodide and a diiodo-substituted aromatic compound to prepare aryl acetylene; and S6, dissolving aryl acetylene in an organic solvent to obtain the aryl acetylene supramolecular polymer with adjustable circular polarization luminescence. The invention develops a CPL material with tunable properties.

The present disclosure provides a tyrosine kinase inhibitor having the general formula (I).R1 is C1-C6 alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, mono-substituted phenyl, poly-substituted phenyl, trifluoromethyl, 2,2,2-trifluoroethyl, CH3O(CH2)n-,R being methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl, cyclopropyl, acetyl or acryloyl, and n being an integer from 1 to 6. R2 and R3 are respectively halogen, hydrogen, amino, substituted amino, cyano, hydroxyl, sulfonic acid group, sulfonamide, trifluoromethyl, 2,2,2-trifluoroethyl, methyl, methoxy or ethynyl. R2 and R3 are in an ortho, para or meta position. Y is NH, O, S or Z—N, where Z is methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl or cyclopropyl. X is Cl, Br or F.

The application discloses a preparation method of 6-ethynylpyrazolo[1,5-a]pyridine, which comprises the following steps: 2,5-dibromopyridine is subjected to a sonogashira coupling reaction to obtain 2,5-di((trimethylsilyl)ethynyl)pyridine; a post-nitrogen amination agent is used for nitrogen amination reaction to obtain 1-amino-2,5-di((trimethylsilyl)ethynyl)pyridine; then, ring closing is carried out under the action of a post catalyst, and a tetrabutylammonium fluoride is used for desilylation to obtain 6-ethynylpyrazolo[1,5-a]pyridine. The preparation method of 6-ethynylpyrazolo[1,5-a]pyridine disclosed by the application has the advantages of low-cost raw materials, easy-to-control reaction conditions, high reaction selectivity, few by-products and suitability for large-scale production.

The present application relates to a kind of heat crosslinking semi-interpenetrating helium separation membrane and its preparation method and application, belong to gas separation membrane field.The present application is synthesized by 2,2'-bis (trifluoromethyl) -4,4'-diamino diphenyl, hexafluoro dianhydride, acetic anhydride and pyridine reaction fluorine-containing polyimide, fluorine is introduced in polymer, can increase the affinity of polymer to helium, increase solubility selectivity, while the pore blocking effect caused by fluorine atom substitution can increase size sieving diffusion selectivity.Using 2,5-dimethyl-p-phenylenediamine monomer and 4,4'- (ethyne-1,2-diyl) di-phthalic anhydride synthesis can be used for heat crosslinking alkynyl polymer.Blending two different polymers can synergistically combine the advantages of different materials, the membrane has good selectivity and permeability, has good heat stability and long-term performance stability.

The invention discloses a production process of polyacrylonitrile-based carbon fibers, and belongs to the related field of carbon fiber production. The production process comprises the following steps: preparing acetylene by adopting a natural gas partial oxidation method and by-producing acetylene tail gas; preparing hydrocyanic acid by adopting a natural gas ammoxidation method; acrylonitrile is synthesized through an acetylene-hydrocyanic acid method; preparing carbon fibers from acrylonitrile; the acetylene tail gas is divided into three parts, one part is used for extracting hydrogen and carbon monoxide; one part is used for synthesizing ammonia; the last part is used for producing methanol; hydrogen extracted from acetylene tail gas is used as hydrogen for carbon fiber synthesis; the ammonia part synthesized from the acetylene tail gas is used for synthesizing hydrocyanic acid; part of the mixed methylamine and methanol synthesized by acetylene tail gas are synthesized into mixed methylamine, dimethylamine separated from the mixed methylamine and carbon monoxide extracted from the acetylene tail gas are subjected to carbonylation reaction to generate dimethylacetamide, and the dimethylacetamide is used for preparing carbon fibers prepared from acrylonitrile. The whole-process industrial chain constructed by the method can realize closed-loop production, and the whole-cycle carbon emission is remarkably reduced while the resource utilization rate is increased.

The invention discloses a non-transfer graphdiyne electrode as well as a preparation method and application thereof, and belongs to the technical field of secondary batteries. The preparation method comprises the following steps: S1, cleaning a current collector, and uniformly depositing copper atoms on the surface of the current collector through magnetron sputtering; s2, dissolving hexaacetylene benzene in a pyridine solution according to a ratio of 1-1.5 mg / 1cm < 2 > / 5min in a dark environment and an argon protection atmosphere, and reacting for 24-48h at 60-110 DEG C, so that a graphdiyne film is synthesized on the current collector in situ; s3, cleaning and removing free copper on the graphdiyne film by using dimethylformamide, acetone and ethanol in sequence, and drying at 60-80 DEG C for 3-12 hours; and S4, heating to 200-500 DEG C at the rate of 1-8 DEG C / min in an inert atmosphere, carrying out heat treatment to obtain a grown graphdiyne film, carrying out heat preservation for 2-10 hours, naturally cooling, and cutting and assembling to obtain an electrode, namely the non-transfer graphdiyne electrode.

The invention provides substituted 2',3'-didehydro-3'-deoxy-4'-ethynylthymidines and related compounds, pharmaceutical compositions, their use for inhibiting LINE1 reverse transcriptase activity, their use for inhibiting HERV-K reverse transcriptase activity, and their use in the treatment of medical disorders, such as cancer.

A water-based inkjet ink comprising a pigment, a surfactant (A), and a water-soluble organic solvent (B), in which the surfactant (A) includes an acetylenediol surfactant (A1) having an ethylene oxide structure and a propylene oxide structure, and having an HLB value of 10 or less; the water-soluble organic solvent (B) includes an alkanediol (B1) having 3 to 5 carbon atoms, and a glycol monoether (B2) having 4 to 10 carbon atoms; and a mass ratio ((B1) / (B2)) between a content of the alkanediol (B1) having 3 to 5 carbon atoms and a content of the glycol monoether (B2) having 4 to 10 carbon atoms is 0.8 to 12.

The application relates to a process involving: contacting 5- ethynyloctahydro-lH-4,7-methanoinden-5-ol (Compound III) with an acid in a reaction zone in the presence of a catalyst and a solvent to form a product mixture comprising 2-(octahydro-5H-4,7- methanoinden-5-ylidene)acetaldehyde (Compound II). The application also relates to a process involving: contacting Compound II with hydrogen in a reaction zone in the presence of a hydrogenation catalyst to form a product mixture comprising 2-(octahydro-lH-4,7- methanoinden-5-yl)acetaldehyde (Compound I). The application also relates to a process involving: (i) converting octahydro-5H-4,7- methanoinden-5-one (Compound IV) to Compound III; (ii) contacting Compound III with an acid in the presence of a catalyst to produce Compound II; and (iii) hydrogenating Compound II in the presence of a hydrogenation catalyst to form a product mixture comprising Compound I. The application also relates to a compound of structural formula (III) and a compound of structural formula (II) respectively in the form of any one of its stereoisomers or a mixture thereof.

An aqueous inkjet ink according to the present invention comprises: pigment particles including a pigment and a pigment dispersion resin coating at least a portion of the surface of the pigment; an acetylenediol-based surfactant (B-1) having a measured HLB value of 6-9; a siloxane-based surfactant (B-2); an alkanediol having 3 or 4 carbon atoms; an alkanediol having 5-8 carbon atoms; and a glycol ether having 4-10 carbon atoms. The pigment dispersion resin includes a crosslinked product of a polymer (A-1) having an aromatic ring and an acid group and an acid value of 50-160 mg KOH / g, and a compound (A-2) having multiple glycidyl ether groups in one molecule. The blended amount of compound (A-2) is such that glycidyl group content is 50-200 mol%.