The invention relates to a placenta oligopeptide probiotic composite preparation and a preparation method thereof. The composite preparation consists of main raw materials of animal (pig, cattle and sheep) placenta extract oligopeptide and probiotics, as well as medical auxiliary materials. The specific preparation method comprises the following steps of extracting placenta oligopeptide from healthy animal placentas through a series of integrated technologies of hydrolyzing, ultrafiltration, nano-filtration, freeze drying and the like, then weighing the following raw materials in percentage byweight of 35-70% of placenta oligopeptide freeze-dried powder, 5-20% of probiotic freeze-dried powder, 2-10% of sodium alginate, 15-20% of starch and 8-15% of fructo-oligosaccharide, performing sufficient and uniform mixing to obtain granules, directly bagging the granules or enabling capsules to be filled with the granules. According to the placenta oligopeptide probiotic composite preparation disclosed by the invention, the animal placenta extract oligopeptide and the probiotics are perfectly combined, and the placenta oligopeptide and the probiotics exert synergistic effects, so that the balance of intestinal microecology can be adjusted, the intestinal tract environment is purified, digestion and absorption of nutrient substances by organisms are promoted, the immune function of the organisms can be strengthened, and the placenta oligopeptide probiotic composite preparation is a purely-natural composite immune adjustment agent.