The invention relates to the deep processing technology of jerusalem artichoke, in particular to a method for producing jerusalem artichoke whole powder, which solves the problems of simple process in the conventional method for producing the jerusalem artichoke whole powder, poor dissolubility and a large number of impurities of the jerusalem artichoke powder due to the single enzyme, damaged nutritional ingredients and flavor of products and the like. In the method, powder is prepared from natural and fresh jerusalem artichoke serving as a main raw material through the steps of cleaning, blanching, mashing, colloid milling, enzymolysis, homogenizing, sterilizing, centrifugation, micro-filtration, drying, powder collecting, sieving, packaging and product warehousing. In the method, a wet process is adopted, and the processes of blanching, enzymolysis and spray drying are introduced, so the problems of poor color and luster, mouthfeel and dissolubility of the conventional products are solved, the quality and yield of the products are improved, and the production cost is reduced.