83 results about "Maleic acid diethyl ester" patented technology

This invention discloses anti inverse ester preparation method. 2-acetonyl-1, 4 diethyl succiante is high pressure condensed by diethyl maleate and acetone under organic amine condition. Then it cycles to get 3, 5-dioxygen hexahydrobenzoic acid ethyl esterunder sodium alcoholate condition, finally anti inverse ester is got by reacting with ring third formic anhydride under alkali condition. The operation is simple, reaction is wild, material is easy to get, yield is high, product purity is high, and generating cost is reduced, so it is propitious to industrial manufacure.

The invention discloses a polyurea floor coating and preparation and application methods thereof as well as carbamide resin. The carbamide resin is polyaspartic acid ester carbamide resin; the polyaspartic acid ester carbamide resin is prepared by reacting diethyl maleate and 3,3-dimethyl-4,4-methylenebis(cyclohexylamine) as raw materials at 60-80 DEG C for 70-74 DEG C, with the weight ratio of the diethyl maleate to the 3,3-dimethyl-4,4-methylenebis(cyclohexylamine) is 1.0 to (1.55-1.60). The polyaspartic acid ester carbamide resin can stably exist at a room temperature; the polyaspartic acid ester carbamide resin is taken as a base component; and packing, an assistant and the like are added, so as to prepare the polyurea floor coating disclosed by the invention. The polyurea floor coating and an HDI curing agent are mixed to use at a certain ratio, so that the polyurea floor coating has the advantages of good abrasive resistance, ageing resistance, waterproofness, controllable elasticity and high-strength shock resistance.

The invention discloses a concrete with low slump loss and a preparation method thereof, and relates to the technical field of concrete. The concrete comprises following components in parts by weight:240 to 420 parts of cement, 70 to 100 parts of fly ash, 900 to 1000 parts of river sand, 950 to 1100 parts of broken stone, 190 to 210 parts of water, 5 to 10 parts of water reducer, and 1.8 to 2.2 parts of combined fiber. The water reducer is prepared by the following steps: adding methyl allyl polyoxyethylene ether, diethyl maleate, and water into a reactor, evenly mixing, stirring, then simultaneously dropwise adding maleic anhydride, a water solution of sodium methyl allyl sulfonate, and a water solution of ammonium persulfate, after dropwise addition, keeping the temperature for one hour, cooling to the room temperature, and adjusting the pH value to 5-7 by a hot NaOH saturated solution. The concrete has good dispersibility and fluidity after the modified water reducer is added, andthe concrete quality is largely improved.

The invention discloses a preparation method of trinexapac-ethyl and an intermediate thereof. The method comprises the following steps: under the action of an alkali, reacting acetoacetic ester (I) with diethyl maleate to obtain an intermediate (II), continuing reaction under the action of an acid to obtain diethyl 2-acetonyl-1,4-succinate; cyclizing the diethyl 2-acetonyl-1,4-succinate in the presence of an alkali, and acidifying to obtain ethyl 3,5-cyclohexyldione-formate; esterifying the ethyl 3,5-cyclohexyldione-formate and cyclopropyl formyl chloride in the presence of an acid-binding agent to obtain ethyl 4-cyclopropylformacyl-3,5-dione cyclohexane-carboxylate; and carrying out reaction on the end product under the actions of an organic alkali and a catalyst to obtain the trinexapac-ethyl. The technique has the advantages of favorable reaction selectivity, high yield and fewer byproducts, and is beneficial to obtaining the high-quality trinexapac-ethyl product. The method does not have high requirements for equipment, and avoids high-temperature high-pressure reaction. The method has the advantages of simple technique and mild reaction conditions, and is suitable for industrialization.

The invention relates to a method and device for producing diethyl maleate by virtue of rectification and steam osmosis coupling, belonging to the technical field of separation and application of pervaporation membranes. The method comprises the following steps: in a reaction kettle, heating maleic acid and ethanol under the action of a catalyst to generate diethyl maleate and water, enabling a gaseous mixture above the reaction kettle to flow through a rectification column under the driving of pressure difference, performing heat exchange on the gaseous mixture and a reflux liquid to ensure that ethanol and water mixed gas can flow out from the top of the rectification column, replenishing heat for the ethanol and water mixed gas, putting the ethanol and water mixed gas into steam osmosis membrane equipment, then performing dehydration, condensing dehydrated ethanol, and conveying ethanol to the reaction kettle from the top of the rectification column. A process method disclosed by the invention ensures that water in an esterification reaction system is continuously removed under the condition that other impurities are not introduced, so that the reaction can be promoted to the generation direction of diethyl maleate, and the conversion rate of the reaction can be effectively improved; and an overall esterification reaction and steam osmosis coupling system is less in floor area, is easy to amplify, and is low in energy consumption.

The invention discloses preparation methods for important intermediates of an anthranilic diamide compound, particularly relates to intermediates 2-hydrazino-3-chloropyridine and 1-(3-chloro-2-pyridy)-3-pyrazolidone-5-acetylenecarboxylate and belongs to the technical field of chemical synthesis methods. The preparation method for 2-hydrazino-3-chloropyridine comprises the following steps of: refluxing 2,3-dichloropyridine used as a raw material in hydrazine hydrate and an organic solvent for 6 to 12 hours, and cooling to crystallize to obtain 2-hydrazino-3-chloropyridine. The preparation method for 1-(3-chloro-2-pyridy)-3-pyrazolidone-5-acetylenecarboxylat comprises the following steps of: adding organic solvent and corresponding alkali into 2-hydrazino-3-chloropyridine, adding diethyl maleate, after the raw material disappears, adding glacial acetic acid and refluxing for half an hour, and cooling to obtain white 1-(3-chloro-2-pyridy)-3-pyrazolidone-5-acetylenecarboxylate. By adopting the technology, the yield of 2-hydrazino-3-chloropyridine can reach over 95 percent, and the purity of 2-hydrazino-3-chloropyridine can reach over 95 percent; the yield of 1-(3-chloro-2-pyridy)-3-pyrazolidone-5-acetylenecarboxylate reaches over 70 percent, and the purity of 1-(3-chloro-2-pyridy)-3-pyrazolidone-5-acetylenecarboxylate can reach over 98 percent; and a process is simple, raw materials can be obtained easily, the yield is high, and the purity of a product is high, and the preparation methods are suitable for industrial production.

The invention relates to the field of insecticide synthesis, and discloses a preparation method of chlorantraniliprole. The preparation method comprises the following steps: synthesis of an intermediate I, synthesis of an intermediate II and synthesis of chlorantraniliprole. The method comprises the following steps: reacting 2, 3, 6-trichloropyridine serving as a raw material with hydrazine hydrate under the action of a catalyst A to obtain 3, 6-dichloro-2-hydrazinopyridine, carrying out hydrogenation reduction reaction under the action of a catalyst B to obtain an intermediate I, reacting theintermediate I with diethyl maleate, and preparing the 2-(3-chloropyridine-2-yl)-5-hydroxypyrazole-3-ethyl formate under the action of a catalyst C, and hydrolyzing after bromination to obtain an intermediate II, and preparing chlorantraniliprole from the intermediate II. According to the invention, 2, 3, 6-trichloropyridine is adopted to replace 2, 3-dichloropyridine as a raw material to preparethe intermediate I, so that the defects of difficulty in obtaining the 2, 3-dichloropyridine raw material, harsh synthesis conditions, low yield and the like are avoided, the total reaction yield ofthe intermediate I is improved, the intermediate II is prepared by a one-pot method, the post-treatment operation is reduced, and the synthesis cost of chlorantraniliprole is reduced.

The invention provides a polyurea coating, a preparation method and the application thereof, and a polyurea coating layer. The polyurea coating provided by the invention comprises the following components: a component A, a component B and a nano slurry; the component A is prepared from raw materials including diisocyanate and polypropylene glycol; the component B comprises polyoxypropylene diammonium, diethyl maleate, a dispersant, a leveling agent and a defoaming agent; the nano slurry comprises nano silicon dioxide and an accelerator; the mass ratio of the component A to the component B is 1to 1-4; and the mass ratio of the component B to the nano slurry is 1 to 2.5-6%. The polyurea coating and the polyurea coating layer provided by the invention have good wear resistance, adhesive force, 60-degree gloss, flexibility, salt fog resistance and artificial accelerated aging performance, wherein the salt fog resistance is more than or equal to 1000h.

The inventon relates to a method for synthesizing an aliphatic nano organic titanium polyaspartic acid ester and paints thereof, comprising the following steps of: (1) aliphatic primary amine PACM (or LAROMIN C260) and DEF (diethyl maleate) perform Michael addition reaction to obtain a reaction product A (or B); and (2) the product A (or B) and nano organic titanium precursor oligopolymer (HTH) performs addition reaction to synthesize the aliphatic nano organic titanium polyaspartic acid ester (T-PAEs). Using as a matrix and compounded with a relative auxiliary film forming resin, paint auxiliary agents, pigments, fillers and a matched curing agent based on formula amounts, the aliphatic nano organic titanium polyaspartic acid ester can be prepared to be environment-friendly and solvent-free nano organic titanium sea heavy duty anticorrosion paints.

Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intra-cellularly either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels. The disclosure is also of a unique combination of nutritional supplements including n-acetyl cysteine, vitamin C, 1-glucosamine, n-acetyl d-glucosamine, quercitin, sylimarin, Alpha lipoic acid and high protein, low fat whey that are combined to support various bodily systems involved in glutathione synthesis, reutilization and storage; all intended to elevate glutathione concentration in the mammalian cell.

The invention discloses medicinal application of a compound chemotherapy medicament of artemisinins (dihydroartemisinin, artemisinin succinate, artemisinin methyl ether, or artemisinin ethyl ether), glutathione depleting agents (diethyl maleate, N-ethyl-maleimide or buthionine sulfoximine) and antioxidant enzyme inhibitors (mercapto-succinic acid and 3-amino-triazole), wherein the compound chemotherapy medicament can be used as the compound chemotherapy medicament for liver cancer and multi-drug resistance tumor with efficient, quick effect, low toxicity and low cost. Liver cancer and multi-drug resistance tumor patients orally take the medicament or are applied by intravenous injection; the everyday treatment dosage comprises 1 to 100 milligrams per kilogram of the dihydroartemisinin, the artemisinin succinate, the artemisinin methyl ether or the artemisinin ethyl ether, 1 to 80 millimoles per kilogram of the diethyl maleate, the N-ethyl-maleimide or the buthionine sulfoximine, 1 to 50 milligrams per kilogram of the mercapto-succinic acid, and 1 to 50 milligrams per kilogram of the 3-amino-triazole; the medicament can be used once or repeatedly; and after the treatment, the tumor can disappear or the proliferation of the tumor can be controlled, so the patients can live for a long time and work normally.

The invention discloses a polyurea coating, a coating and a preparation method thereof, and relates to the technical field of coatings. The polyurea coating comprises a component A, and the component A is a mixture of resin, pigment filler and auxiliaries and comprises the following components in parts by weight: 60-90 parts of organic fluorine-silicon modified polyaspartic acid ester resin, 20-40 parts of pigment filler and 1-5 parts of auxiliaries; the preparation method of the organic fluorine-silicon modified polyaspartic acid ester resin comprises the following steps: (1) mixing polyaspartic acid ester resin, gamma-aminopropyl trialkoxysilane and trifluoropropyl methyl cyclotrisiloxane, introducing inert gas, heating to 50-60 DEG C after 5-10 minutes, and dropwise adding diethyl maleate while stirring to obtain a mixture; and (2) carrying out heat preservation reaction on the mixture for 8-16 hours, and cooling to obtain the organic fluorine-silicon modified polyaspartic acid resin.

The invention discloses a method for catalytically synthesizing diethyl maleate by using acidic ionic liquid. The method comprises the following steps: using maleic anhydride and absolute ethyl alcohol as raw materials, using the acidic ionic liquid as a catalyst and using cyclohexane as a water-carrying agent to be added into a reaction bottle, heating, stirring, reacting, condensing and refluxing; after the reaction is finished, standing and layering into a reaction product layer and a catalyst layer, washing the reaction product layer with a sodium bicarbonate aqueous solution and distilledwater in sequence, and drying to obtain a diethyl maleate product, wherein the acidic ionic liquid is one of the following components. The method has the advantages of high product yield, high product purity, good catalyst separation efficiency and the like, and the recovered catalyst can be reused. The method can effectively reduce the cost of subsequent treatment of wastewater pollution and theuse cost of the catalyst and has a very good application prospect.

The invention discloses a polyurea floor coating material, a preparation method and a use method thereof, and a polyurea resin, wherein the polyurea resin is a polyaspartic ester polyurea resin, and diethyl maleate and 3,3-dimethyl-4,4-diaminodicyclohexylmethane are used as raw materials and are subjected to a reaction for 70-74 h at a temperature of 60-80 DEG C according to a weight ratio of 1.0:1.55-1.60 to prepare the polyaspartic ester polyurea resin. According to the present invention, the polyaspartic ester polyurea resin can stably exist at a normal temperature; the polyurea floor coating material can be prepared by using the polyaspartic acid ester polyurea resin as the matrix component and adding the filler, the auxiliary agent and the like; and after the polyurea floor coating material and the HDI type curing agent are mixed according to a certain ratio, the advantages of good wear resistance, good aging resistance, good water resistance, controlled elasticity and high impactresistance can be achieved.

Belonging to the field of coating processing, the invention in particular relates to an aspartic ester self-leveling coating and a preparation method thereof. The coating comprises the following components: 97.8 weight parts of aspartic ester; 1 weight part of a dispersant; 0.3 weight part of a defoaming agent; 0.5 weight part of a wetting agent; 0.4 weight part of a leveling agent; and 140-160 weight parts of quartz sand. According to the invention, di-n-butyl maleate is adopted as the raw material to replace a part of diethyl maleate to react with diamine so as to prepare aspartic ester. The branch chain extension reduces the overall reaction speed of aspartic ester, the usable time of the coating is prolonged, and the coating still can maintain the fast drying characteristic. The prepared paint film has excellent surface state.

The present invention discloses a diethyl maleate preparation method, which concretely comprises: adding maleic anhydride, absolute alcohol, a solid acid catalyst and a water carrying agent to a reaction container, installing a water segregator, a reflux condensation pipe and a thermometer on the reaction container, heating to carry out reflux water separation, carrying out a reaction until no water drop appears, then continuously carrying out the reaction for 25-30 min, stopping the heating, carrying out room temperature cooling for 30 min, discharging the water layer, washing the reaction solution with water, drying, distilling, distilling out the front distillate, and collecting the distillate with a temperature of 216-220 DEG C so as to obtain the product. According to the present invention, the solid acid catalyst is used, such that the fed material conversion rate can be improved to more than or equal to 99.5% from the usual less than or equal to 95%; and the waste liquid emission problem caused by the addition of sodium carbonate to neutralize the excess acid in the liquid catalyst process can be avoided.

The invention discloses a method for synthesizing prohexadione calcium and trinexapac-ethyl. The method comprises the following steps: reacting diethyl maleate (alpha, beta unsaturated carboxylic acid) with sodium ethoxide to obtain high-purity intermediate compound as shown in a formula II, and preparing prohexadione calcium and trinexapac-ethyl from the compound as shown in the formula II. In the reacting steps for preparing the compound as shown in the formula II, sodium ethoxide serving as a reactant participates in the reaction rather than a strong basic catalyst; a 1,3-cyclohexanedione compound is prepared from the intermediate compound as shown in the formula II and acetone under a reflux condition, and the total yield for the reaction of two steps can be 87 percent. The method has the advantages of low energy consumption, short reaction time, easy operation and the like by using the 1,3-cyclohexanedione compound as the intermediate, and can be used for preparing prohexadione calcium and trinexapac-ethyl with high yield.

The invention discloses a preparation method of a nanometer modified polyurea waterproof coating, and belongs to the technical field of preparation of coatings. The preparation method comprises the following steps of mixing diethyl maleate and polyether amine D2000, mixing MDI-50 and polyether D2000, and stirring to react, so as to obtain a pre-polymer, wherein a plant extracting solution containsa plurality of conjugated double bond systems with stronger ability of providing electron pairs. The preparation method has the advantages that the nanometer zinc oxide powder is uniformly dispersedto the surface of a substrate under the polarity adsorption function of the plant extracting solution, and the energy gap width of the nanometer zinc oxide powder is 4.5eV and is equivalent to the energy of most of ultraviolet rays, so as to reduce the strength of ultraviolet rays in the radiation direction; the calcium carbonate crystals in scallop shell powder are crossly and densely stacked, the nanometer zinc oxide is promoted to be filled into the scallop shell powder, and a concentrated solution containing lecithin is continued to add, so that the interface tension of water is reduced; the wetting property of the solid/liquid system is changed, the wetting property of the polyurea waterproof coating is improved, and the application prospect is broad.

The invention discloses a bisamide compound and a synthesizing method and application thereof. The synthesizing method includes: allowing 2,3-dichloropyridine to have reaction with hydrazine hydrate to obtain 3-hydrazino-2-chloropyridine; subjecting the 3-hydrazino-2-chloropyridine and diethyl maleate to cyclization and hydrolysis to obtain 3-hydroxy-1-(3-chloropyridine-2-yl)-1H-pyrazol-5-formic acid; subjecting the 3-hydroxy-1-(3-chloropyridine-2-yl)-1H-pyrazol-5-formic acid and substituted o-amino-benzoic acid to cyclization to obtain 2-(-1-(3-chloropyridine-2-yl)-1-H-pyrazol-5-yl)-8-methyl-4H-3,1- benzoxazine-4-ketone; subjecting the 2-(-1-(3-chloropyridine-2-yl)-1-H-pyrazol-5-yl)-8-methyl-4H-3,1- benzoxazine-4-ketone and 40% ammonia water solution to aminolysis to obtain the bisamide compound. The compound containing the bisamide group is simple to prepare, excellent in insecticidal activity and capable of being used as an insecticide.

The invention discloses a novel anti-crack fiber and composite material preparation method. The formula comprises polypropylene, diethyl maleate, styrene, dicumyl peroxide, polyurethane resin, a reinforcing agent, an organic silicon defoaming agent and a coloring agent, and specifically 82-94 parts of polypropylene, 17-23 parts of diethyl maleate, 6-10 parts of styrene, 2-4 parts of dicumyl peroxide, 9-13 parts of polyurethane resin, 3-7 parts of the reinforcing agent, 1-3 parts of the organic silicon defoaming agent and 1-3 parts of the coloring agent in parts by weight. The composite material is used for replacing a traditional single material, the performance of the anti-crack fiber is reinforced, the use requirement of a high-strength scene is met, the application range of the anti-crack fiber is expanded, and the service life of the anti-crack fiber is prolonged; and polypropylene is subjected to grafting modification treatment in the preparation process, therefore, the performance of polypropylene is improved, and the comprehensive performance of the anti-crack fiber is improved.