The invention provides a preparation method of
sodium nitroprusside injection. The preparation method comprises the following steps: (1) accurately weighing
sodium nitroprusside according to a
mass volume ratio of each 50g of
sodium nitroprusside: added water for injection enabling a solution to reach 100mL, adding the water for injection to the
sodium nitroprusside so as to dissolve the
sodium nitroprusside into a 20%-30% concentrated solution, adding 0.1-0.2% of
activated carbon, stirring for 15-25 minutes, and carrying out coarse
filtration so as to remove carbon; (2) supplementing the water for injection, and then carrying out refined
filtration by using a filtering membrane; and (3) respectively filling the solution subjected to refined
filtration into sterile
penicillin bottles, partially stoppering, putting in freeze-
drying equipment, and carrying out freeze-
drying according to a freeze-
drying curve. The preparation method has the advantages that proper temperature, pressure and heating rate are adopted in a preparation process, the intense
moisture absorption of an inner loose structure of the product is avoided, the product is prevented from absorbing
moisture again after being dried, the occurrence of the shrunk product is reduced, and the percent of pass is increased; and additives for improving surface activity do not need to be added, the risk caused by
impurity introduction is reduced, and the production efficiency is improved.