The invention relates to an ultra-pure tantalum with controllable tissues and textures and a preparation method and application thereof. The purity of ultra-pure tantalum is greater than or equal to 99.995%, the grain size degree is 45-80 [mu]m, the{100} texture content is not greater than 15% in the thickness direction of a panel, the {111}texture content is greater than or equal to 33%, the ultimate strength is 372-410 MPa, the yield strength is 260-287 MPa, the ductility is 41-46%, and the hardness is 87-89 HV. The preparation method comprises the steps of high vacuum degree (10<-4>Pa) electron beam smelting furnace, argon chamber stainless steel sleeve packaging, three-dimension heat forging cogging of cooperative control of gate forging deformation amount and total deformation amount,multiple variable angle control rolling and heat treatment, turning, packaging and the like. According to the process, the distribution of grain sizes and the grain size degree of finished products can be effectively controlled, and the finished products and texture distribution of the finished products in the thickness direction are effectively regulated and controlled. Necessary conditions areprovided for the finished products to be used as high-quality target materials.