91results about How to "Fast crosslinking" patented technology

The invention relates to injectable silk fibroin-alginate double cross-linking hydrogel which comprises a solution A: a silk fibroin solution and a solution B: a modified alginate solution, wherein the solution A comprises the following components in parts by weight: 1.0*10<-1>-3.0 parts of silk fibroin, 1.4*10<-3>-2.0*10<-3> part of a divalent metal ion cross-linking agent, and the balance of water containing 1-5wt% of silk fibroin; the solution B comprises the following components in parts by weight: 5.0*10<-1>-4.0 parts of alginate, 2.5*10<-3>-4.0*10<-1> part of a carboxyl activating cross-linking agent and the balance of water containing 1-5wt% of alginate. By adopting a double cross-linking method of covalent cross-linking and ion cross-linking, the double cross-linking hydrogel is quick to polymerize in situ and has an application prospect in the fields such as engineering stents, drug controlled release and regenerative medicines. The invention further provides a preparation method and a use method of the double cross-linking hydrogel.

The invention provides a styrene-butadiene rubber modified asphalt composition and a preparation method thereof. The preparation method comprises the following steps of: grinding styrene-butadiene rubber grains or powder by using special equipment such as a high-shear equipment, colloid mill or the like at the temperature of between 150 and 230 DEG C, and uniformly dispersing in base asphalt to prepare a modified asphalt composition; adding a composite additive in an amount which accounts for 0.01 to 0.2 percent of the total weight of asphalt with the common stirring or stirring by using a high-shear emulsifying machine; and performing cross-linking reaction to prepare a styrene-butadiene rubber modified road asphalt product. The styrene-butadiene rubber modified asphalt has a simple production process; and the asphalt product has higher toughness and tenacity, high high-temperature performance and high low-temperature performance and is suitable for building high-grade highways.

The invention relates to a fracturing fluid cross-linking agent and a preparation method and application thereof. The cross-linking agent prepared by the invention can rapidly react with dialkyl phosphate, so that gelled fracturing fluid is formed by lower alkanes. The preparation method of the cross-linking agent comprises the following steps: (1) preparing a complex solvent, namely mixing an alcohol and water according to the mass ratio of 1:2-1:4, stirring uniformly, thereby obtaining the complex solvent; (2) sequentially adding the following components in parts by mass into a reaction container: 40-70 parts of the complex solvent, 30-60 parts of a trivalent iron salt and 6-25 parts of a complexing agent, and stirring and reacting at the temperature of 50-70 DEG C for 3-4 hours; and (3) cooling the reaction solution to the temperature of 30 DEG C, adding 2-8 parts of a cross-linking accelerator, uniformly stirring, thereby obtaining the lower alkane anhydrous fracturing fluid cross-linking agent.

The invention discloses a silane quickly cross-linked polyethylene cable material and belongs to the technical field of electric wire and cable materials. The silane quickly cross-linked polyethylene cable material is characterized in that: a base material comprises the following components: 40 to 85 parts of low density polyethylene (LDPE) and 15 to 60 parts of linear low density polyethylene (LLDPE); a catalyst master batch comprises the following components: 100 parts of low density polyethylene (LDPE) which is one or a mixture of more polyethylenes, 1 to 10 parts of antioxidant, 1 to 10 parts of copper inhibitor, 3 to 20 parts of catalyst, and 0.01 to 1 part of cross-linking reaction active agent; and a silane cross-linked compounding ingredient comprises the following components: 100 parts of silane and 10 to 50 parts of initiator which are uniformly mixed. The silane quickly cross-linked polyethylene cable material has the advantages that: the defects of the warm water cross-linked cable material technology are overcome; the cable material can be quickly cross-linked under the natural conditions; and the cross-linked curing reaction of the cable can avoid soaking in warm water or can be finished in short soaking time while meeting all performance requirements; and a large quantity of energy sources are saved.

The invention relates to acid liquid for acid fracturing and a preparation method thereof. The acid liquid for acid fracturing consists of the following substances: 5-40 weight percent of acid, 0.3-2.0 weight percent of polyacrylamide polymer, 0.03-1.5 weight percent of zirconium oxychloride, 0.03-1.5 weight percent of aldehyde cross-linking agent, 0.03-1.5 weight percent of phenol cross-linking agent and remaining weight percent of water, wherein the aldehyde cross-linking agent is at least one of aldehyde compounds and derivatives thereof, and the phenol cross-linking agent is at least one of phenol compounds and derivatives thereof. The acid liquid provided by the invention has the advantages of high viscosity, high adjustability, high elasticity and high temperature resistance after cross-linking, thereof the goals of acid liquid deep penetration and acid fracturing slot creation can be achieved, the cost is reduced, the harm to human bodies and the environmental pollution during construction are reduced and the acid fracturing reconstruction effect can be effectively improved.

The invention discloses a reversibly crosslinked biodegradable polymersome with an asymmetric membrane structure as well as a preparation method and application thereof to nucleic acid medicines. The polymersome and the preparation method have the advantages that a triblock polymer PEG-P(TMC-DTC)-PEI or PEG-P(DLLA-DTC)-PEI is synthesized and is self-assembled and self-crosslinked to obtain the polymersome with the asymmetric membrane structure or the triblock polymer is linked with a targeting molecule and is self-assembled to obtain targeting RCCPs; the inner shell of the polymersome is PEI and is used for compounding and loading nucleic acid through electrostatic interaction; a membrane is reversibly crosslinked biodegradable polyester / polycarbonate with good biocompatibility; dithiolane of a side chain is similar to a human body natural antioxidant lipoic acid; the outer shell of the polymersome takes PEG as the background and can target cancer cells; by studying that the carrier is compounded with functional siRNA and studying the gene silencing effects in vitro and vivo, in vivo blood circulation and bio-distribution, the condition of treating lung cancer in situ bearing mice and toxic and side effects of the polymersome, the polymersome is expected to become a nanosystem platform integrating the advantages of simplicity, stability, multifunction, and the like and is used for carrying out efficient and active targeting delivery on siRNA to tumors in situ.

The invention discloses a self-crosslinked expansion flame-retardant material and a preparation method thereof and relates to a self-crosslinked expansion flame-retardant material and a preparation method thereof. The invention aims at solving the problems of long time consumption, harsh environmental requirements and low comprehensive performances of the existing flame-retardant material. The self-crosslinked expansion flame-retardant material is prepared from 94-96 parts of a material A, 2-4 parts of a material B and 1-3 parts of a material C by weight. The method comprises the following steps: 1) preparing flame-retardant resin; 2) preparing the material A; 3) preparing the material B; 4) preparing the material C; and 5) mixing the materials, and extruding and granulating to obtain the self-crosslinked expansion flame-retardant material. The method disclosed by the invention is used for preparing the self-crosslinked expansion flame-retardant material.

To provide a transparent structure retrieval function while optimizing an MXL document-relational table schema mapping definition.A mapping definition tuning module 105 refers to issuing history of a structure retrieve formula to change a schema-to-schema mapping definition 109 so that an XML document is properly divided and stored in a relational database 105 and a structure retrieval engine 106 for the purpose of enhancing the efficiency of retrieval processing with high issuing frequency. A structure retrieval formula conversion module 102 converts the structure retrieval formula based on the schema-to-schema mapping definition 109. A query execution control module 103 issues queries to the relational database 105 and the structure retrieval engine 106, respectively, and reconstitutes a result for the original structure retrieval formula from the respective results.

The invention relates to a preparation method of an enzymatic cross-linking medicine carrying nano micelle. The preparation method comprises the following steps: carrying out self-assembling to prepare a polymer micelle system by using a thermosensitive amphiphilic block copolymer, introducing a phenol group capable of generating cross-linking reaction into a thermosensitive block, catalyzing peroxidized hydroxide phenol group by Peroxidase to generate cross-linking reaction to obtain a nuclear crosslinking polymeric micelle, wherein the lowest critical micelle concentration is remarkably lower than that of nano micelle which is not cross-linked; when the micelle is prepared, adding adriamycin, taxol or camptotheca acuminate to prepare the enzymatic cross-linking medicine carrying nano micelle. The preparation method provided by the invention has the advantages that compared with conventional cross-linking methods, the preparation method has the advantages of safety, no toxicity, quick cross linking and the like, and is simple and convenient to operate, and has a good application prospect; the enzymatic cross-linking medicine carrying nano micelle has lower critical micelle concentration, so that the stability is improved, the circulating time of the micelle in blood can be prolonged and the efficiency that the micelle is endocytosed by tumor cells is increased, thereby further improving the bioavailability and the therapeutic effect of the medicine.

The invention discloses a process for preparing an emulsion explosive by on-site upward deep hole filling. The process is characterized by comprising the following steps: (1) preparation of the emulsion: a, preparation of an aqueous phase; b, preparation of an oil phase; and c, mixing emulsification of the aqueous phase and the oil phase; (2) upward hole charge and crosslinking to obtain the emulsion explosive: heating the emulsion to 76.7-85.6 DEG C, mixing the emulsion with a crosslinking agent by a charging machine, and quickly filling the emulsion into the hole, so as to obtain a hard and dry crosslinking emulsion explosive in a minute; and (3) sensitization treatment: adding a sensitizing material into the crosslinking emulsion explosive to finally form the emulsion explosive. According to process for preparing the emulsion explosive by on-site upward deep hole filling provided by the invention, the emulsion explosive can conduct rapid crosslinking during filling, and does not fall out off the hole, so as to realize no explosive waste, save resources and reduce the cost.

The invention provides albumin hydrogel. The albumin hydrogel is prepared by mixing albumin, a cross-linking agent and a solvent, the cross-linking agent comprises a repeating unit having a structureof formula (I) and an end group having a structure of formula (II). The invention develops the albumin hydrogel which is rapid in crosslinking, low in gelatinization concentrating and free of biotoxicity, and the albumin hydrogel is applied to the fields of cell culture, tissue engineering and drug delivery. Besides, as a good paclitaxel topical treatment drug carrier, the albumin hydrogel overcomes the defect of poor paclitaxel solubility, polyoxyethylene castor oil with biotoxicity is not introduced, and compared with a systemic preparation, the albumin hydrogel has the advantages that the administration frequency is effectively reduced, the drug concentration at a tumor is increased, and the systemic toxicity is reduced. Nanoparticles wrapping paclitaxel are used as gel forming components of the gel, so that uniform distribution of the paclitaxel in the gel can be realized, and stable and continuous release is realized.

The invention discloses a temperature-resistant foam gel as well as a preparation method and application thereof. The temperature-resistant foam gel comprises the following components in percentage bymass: 0.3% of a polymer; 0.15%-0.35% of a cross-linking agent; 0.05%-0.15% of a foaming agent; and the balance water; the cross-linking agent is a cross-linking agent A or a mixture of the cross-linking agent A and a cross-linking agent B, and the cross-linking agent A is resorcinol; and the cross-linking agent B is formaldehyde. It is found by observing microstructures of water-based foam, polymer solution foam and the foam gel by using a microscope and a scanning electron microscope that common foam and polymer cannot keep stable for a long time due to flowing of a liquid film at normal temperature, and the liquid film of the foam gel forms a reticular gel structure, so that the viscosity and strength of the liquid film are enhanced, the flowing of the liquid film is hindered, and the foam gel has better stability at high temperature. It is shown by low-permeability fracture type rock core plugging experiment, the foam gel system can form effective plugging in rock cores, has a goodgas breakthrough inhibition effect, and has a wide application prospect in low-permeability oil reservoir.

The invention discloses liquid crystal epoxy resin as well as a preparation method and an application thereof. The preparation method comprises the following steps: reacting 3,5'-di-tert-butyl-5,3'-dimethyl biphenol with excessive epichlorohydrin in the presence of a phase transfer catalyst, thereby obtaining 3,5'-di-tert-butyl-5,3'-dimethyl diphenyl diglycidyl ether, wherein the softening point of 3,5'-di-tert-butyl-5,3'-dimethyl diphenyl diglycidyl ether is measured to be 10 DEG C through DSC, and the 3,5'-di-tert-butyl-5,3'-dimethyl diphenyl diglycidyl ether is a thick non-solid product at the room temperature; then, selecting a proper curing agent to pre-cure at a low temperature, enabling a biphenyl rid-rod-shaped structure to orientate and arrange with enough time, curing and cross-linking at a high temperature, thereby obtaining a liquid crystal structure. Compared with the conventional preparation method for the rigid-rod-shaped epoxy resin, the preparation method disclosed by the invention is low in curing cost.

The invention discloses a preparation method and application of drug sustained-release carrier hydrogel, and belongs to the technical field of medical polymers. The preparation method comprises the following steps: firstly, synthesizing beta-cyclodextrin with a bisacrylamide group with a hydrophobic cavity structure by taking beta-cyclodextrin and acryloyl chloride as raw materials, then preparing methylacryloylated gelatin from gelatin and methacrylic anhydride, and then performing free radical copolymerization under 365nm ultraviolet light by taking Irgacure2959 as an initiator, thereby obtaining the hydrogel. The drug loading capacity of the drug carrier hydrogel can reach 40.86 mg / g, and the drug carrier hydrogel can be continuously released for more than 96 hours in different environments (normal in-vivo physiological environment, lesion site environment and simulated gastric juice environment). A drug sustained-release carrier hydrogel system prepared by the invention is safe and non-toxic, has solubilization on hydrophobic drugs, improves the medication efficiency, and broadens the application range of the hydrogel in the field of medicines.

The invention relates to a self-crosslinking macromolecular dust suppressant and a preparation method thereof and belongs to the technical field of environmental pollution improvement and particularly relates to the self-crosslinking macromolecular dust suppressant and the preparation method thereof. The self-crosslinking macromolecular dust suppressant is characterized by being prepared by taking styrene (St) as a hard monomer, ethyl acrylate (EA), 2-ethyl hexyl acrylate (2-EHA) as a soft monomer, introducing acrylic acid (AA) and acrylamide (AM) as a functional monomer, diacetone-acryloamide (DAAM) and adipic dihydrazide (ADH) as a self-crosslinking monomer, taking persulfate as an initiator, alkyl diphenyl ether disulfonate (DSB) as an emulsifier and allyloxyl nonylphenol ether ammonium sulfate (DNS-86) as a reactive emulsifier by virtue of a seed emulsion polymerization method. The self-crosslinking macromolecular dust suppressant provided by the invention has excellent wear resistance, water resistance, resistance to acid and base and corrosion resistance and is an environment-friendly green product.

The invention discloses a graphene natural rubber polymer anti-slip mixed foaming material on ice and a preparation method of the mixed foaming material. The mixed foaming material is prepared from the following raw materials in parts by weight: 50-60 parts of natural rubber, 32-37 parts of butyl rubber, 8-12 parts of cis-polybutadiene, 4-6 parts of white carbon black, 2.4-2.8 parts of basalt fibers, 2-3 parts of nano silicon dioxide, 2.2-2.6 parts of graphene, 1.4-1.7 parts of silicone oil, 1.2-1.5 parts of zinc oxide, 1.5-2.0 parts of zinc stearate, 1.8-2.4 parts of stearic acid, 1.6-1.9 parts of a cross-linking agent, 4.5-5.5 parts of a flow promoting agent, and 1.5-2.0 parts of a foaming agent. The graphene natural rubber polymer anti-slip mixed foaming material on the ice provided bythe invention has a high anti-slip coefficient, a good anti-slip effect, good low-temperature resistance, a good low-temperature anti-slip effect, high tensile strength, good mechanical properties, low abrasion, good wear resistance and long service life.

The invention discloses a graphene high-elasticity rubber elastomer high polymer material and a preparation method thereof. The high polymer material is prepared from the following raw materials by weight: 45-50 parts of natural rubber, 15-19 parts of styrene-butadiene rubber, 10-14 parts of an ethylene-octene copolymer, 13-16 parts of an ethylene-butyl acrylate copolymer, 16-20 parts of an ethylene-vinyl acetate copolymer, 2.4-3.0 parts of grapheme, 6.5-8.5 parts of silane coupling agent modified glass fiber, 1.6-2.1 parts of a foaming agent, 0.82-0.95 part of a micropore regulator, 1.8-2.2 parts of a bridging agent, 2-4 parts of polyethylene wax, 3-5 parts of maleic anhydride grafted polypropylene, 1.8-2.4 parts of a cross-linking agent, 3.5-5.5 parts of an antioxidant and 3-4 parts of aheat stabilizer. The product disclosed by the invention has good resilience and memory function, also has high elasticity, still has very low permanent compression set value at -40DEG C, and has goodflexibility.

Belonging to the field of paint, the invention in particular relates to a dual anticorrosive waterborne primer suitable for an outdoor metal substrate. The primer is composed of a component A and a component B in a weight ratio of 20:3. The component A consists of the following raw materials by weight: 20-30 parts of deionized water, 20-40 parts of water-based resin, 20-30 parts of pigment, 3-7 parts of graphene oxide, 1-2 parts of a coupling agent, 0.5-1 part of a dispersant, 0.3-1 part of an organosilicon leveling agent, and 5-6 parts of lotus leaf powder. The component B consists of the following raw materials by weight: 20-40 parts of polyamide, 3-8 parts of a catalyst, and 40-60 parts of pyromellitic acid. The primer film can undergo crosslinking rapidly to form a film under an ultralow temperature condition, is good in various tolerance, can tolerate salt mist for 3000h, acid and alkali for 1000h or more and water up to 180d or more.

The invention relates to an anti-pre-crosslinking rapid-solidification low-smoke zero-halogen flame-retardant silane crosslinking nano-modified polyolefin composition. The composition is prepared from, by weight, 100 parts of zero-halogen flame-retardant silane grafted nano-modified polyolefin matrixes A and 4-6 parts of catalyst master batches B. By the adoption of a fractional step method, a preparation method includes the steps that the zero-halogen flame-retardant silane grafted nano-modified polyolefin matrixes A and the catalyst master batches B are prepared and then mixed evenly, wherein the zero-halogen flame-retardant silane grafted nano-modified polyolefin matrixes A are formed by mixing nano-modified polyolefin, zero-halogen flame-retardant master batches, a silane grafted system and anti-pre-crosslinking agents, and the catalyst master batches B are formed by mixing carrier resin polyolefin and a rapid catalyst system. By the application of the method, the anti-pre-crosslinking low-smoke zero-halogen flame-retardant silane crosslinking nano-modified polyolefin composition capable of achieving rapid crosslinking under natural conditions can be prepared, the performance of the composition meets using requirements, and particularly, the composition can also be used for producing heat-resistant flame-retardant pipes when serving as a low-smoke zero-halogen flame-retardant silane crosslinking polyolefin cable material.

The invention discloses a drug-loaded polymer vesicle with an asymmetric membrane structure, a preparation method and application in preparation of a drug for treating acute myeloid leukemia. An amphiphilic triblock polymer with polyaspartic acid PAsp, a targeted amphiphilic block polymer and a small molecule drug are assembled together to prepare the targeted small molecule drug-loaded polymer vesicle with the asymmetric membrane structure. The drug-loaded polymer vesicle disclosed by the invention has many unique advantages, including small size, simple and controllable preparation, reversible crosslinking, in-vivo stability, targeted delivery, high intracellular drug enrichment concentration, sensitive reduction, efficient killing of tumor cells, significant tumor growth inhibition effect and the like, and especially the drug-loaded vesicle disclosed by the invention has effective inhibition on both acute myeloid leukemia cell lines and patient cells. Therefore, the polymer vesicleis expected to become a simple and multifunctional nano platform for efficient and specific targeted delivery of drugs to tumor cells.

The invention relates to a method for producing cross-linkable formulations. In a first step of the method, at least one alpha, omega-difunctional organic polymer of formula (1) X-A-X (1) is converted into organyloxysilyl-terminated polymers P1, using organofunctional silanes of formula (2) Y-R-Si-(R1)m(-OR2)3-m (2) in the presence of catalysts (A) selected from the group consisting of potassium,iron, indium, zinc, bismuth and copper compounds. In said formulae, R is a bivalent, optionally substituted hydrocarbon group which comprises between 1 and 12 carbon atoms and can be interrupted withheteroatoms, R1 and R2 are the same or different, monovalent, optionally substituted hydrocarbon groups which comprise between 1 and 12 carbon atoms and can be interrupted with heteroatoms, A is a bivalent, optionally substituted hydrocarbon group which comprises at least 6 carbon atoms and can be interrupted with heteroatoms, m is equal to 0, 1 or 2, X is a hydroxyl group, and Y is an isocyanategroup, or X is an isocyanate group and Y is a hydroxyl group or a primary or secondary amino group. In a second step, the polymers P1 obtained in the first step are mixed with a silane condensation catalyst (B) selected from the group consisting of compounds of elements of the third main group and / or fourth secondary group and heterocyclic organic amines, amine complexes of the element compounds,or the mixtures thereof. Optionally, said mixture is mixed with other substances (C). The formulations do not contain organic tin compounds, and are suitable for using as adhesives, sealants or coating agents.

The invention discloses a quick crosslinked ethylene-vinyl acetate copolymer (EVA) adhesive film for a double-glazed module, and a preparation method of the EVA adhesive film. The EVA adhesive film is prepared by mixing an EVA, a compatibilizer, a photoinitiator, a crosslinking agent, a defoaming agent and an antioxidant. The preparation method comprises the following steps: A. evenly mixing the EVA with the photoinitiator, the crosslinking agent, the compatibilizer, the defoaming agent and the antioxidant; B. evenly mixing the raw materials in a high mixing machine, and putting the mixture into an extruder for mixing, wherein the temperature of the extruder is controller to be within a range of 80-120 DEG C; C. carrying out tape casting, embossing, cooling, ultraviolet (UV)-curing and prepolymerization to form a film; carrying traction cutting, and finally winding to obtain the EVA adhesive film; D. packaging photovoltaic coated glass, a battery piece or the double-glazed module by means of the quick crosslinked EVA adhesive film for the double-glazed module. The method provided by the invention is easy to implement, simple and convenient to operate and lower in cost, reduces the processing time of the double-glazed module, and does not generate a merged piece; the defoaming agent is adopted as the raw material, so that the module is improved to be free from bubbles, and the yield of double-glazed modules is increased to be more than 99%; the preparation method is suitable for large-scale production.

The invention provides a silane crosslinked polyethylene cable material. The cable material is prepared from the following raw materials, by weight, 80-90 parts of low-density polyethylene, 10-20 parts of high-density polyethylene, 5-10 parts of polyvinyl chloride, 2-3 parts of silane coupling agent KH5502, 0.1-0.2 part of anti-oxidants, 0.1-0.5 part of nano titanium dioxide, 0.2-0.3 part of dioctyltin dilaurate, 15-20 parts of light calcium carbonate, 1-2 parts of talcum powder, 5-10 parts of modified filling materials, 0.2-0.5 part of asphalt, 15-25 parts of aluminum hypophosphite, 1-2 parts of polyisobutylene and 1-2 parts of polytetrafluoroethylene. After tests, various technical indexes of the cable material all reach levels of the same kind technologies abroad. The processing performances and the cable surface quality are good. The cable material can realize rapid crosslinking, the production efficiency is raised, and the cost is reduced.

The invention discloses a method for preparing medicine albumin nanoparticles, and belongs to the technical field of medicine preparations. According to the method disclosed by the invention, metal salt without biologic toxicity or a non-salt compound is used as a coagulator, a natural compound without biologic toxicity is used as a cross-linking agent, and a few of solvents which are nearly nontoxic, such as ethanol, are used as a medicine solvent. Nanoparticles are formed through energy instantaneously released through cavitation. The preparation method of the medicine albumin nanoparticles disclosed by the invention has the advantages that the preparation method is environmentally-friendly, organic solvents having medium and high toxins are not used, an emulsifying and volatilizing process is not included, besides, the solidification effect and the dispersion effects of the nanoparticles are completed at the same time, a few technology steps are used, and the time consumption is short. The particle diameter of the medicine albumin nanoparticles prepared by the method is generally smaller than 800nm.

The invention discloses a waterborne glass baking varnish which is prepared from the following components in percentage by weight: 60-80 percent of waterborne resin, 0.3-0.8 percent of an acid catalyst, 0.7-5.5 percent of a pH regulator; 0.1-0.5 percent of a thickener, 1-8 percent of a cosolvent, 0.1-1 percent of a wetting agent, 1-9 percent of a film-forming additive, 0-20 percent of a pigment and 5-25 percent of water. For the waterborne glass baking varnish provided by the invention, selections and dosages of various components are comprehensively considered, and the selected waterborne resin can ensure high glossiness, high hardness and strong weatherability of a varnish film; and use of the acid catalyst can promote rapid crosslinking of matrix resin, lower the solidification temperature and increases the solidification degree. In addition, the waterborne glass baking varnish provided by the invention is non-pollution to environment, nonhazardous to an operator, strong in coatingadhesion force and good in flexibility has higher hardness, excellent abrasive resistance, water resistance, alcohol resistance and salt fog resistance and can be widely used for glass products such as winebottles and perfume bottles.

The invention discloses application of targeted reduction response vesicular nanometer medicines in preparation of brain tumor treatment medicines. Reduction sensitive reversible crosslinking vesiclesbased on block polymers PEG-P(TMC-DTC), PEG-P(LA-DTC), PEG-P(TMC-DTC)-PEI, PEG-P(LA-DTC)-PEI, PEG-P(TMC-DTC)-Sp or PEG-P(LA-DTC)-Sp and targeting polymers with ANG as the targeting molecules can efficiently wrap small-molecular chemotherapy medicines, protein medicines and gene medicines sensitive to brain glioma cells. The medicine-carrying vesicles can efficiently permeate through a blood brainbarrier in vivo to enter tumor substances and can also rapidly release medicines after entering tumor cells to induce cell apoptosis. The system has the advantages that the process is simple, the carrier biocompatibility is good, the enrichment of medicines at brain tumor parts is remarkably improved, and the concentration of medicines in brain tumor cells is increased. By means of the system, medicines can be conveyed to brain glioma selectively and efficiently.

The flame-retardant anti-dripping copolyester based on high-temperature self-crosslinking disclosed by the invention is composed of structural units represented by I, II, III and IV, the intrinsic viscosity [eta] of the copolyester is 0.20-3.50 dL / g, the limit oxygen index is 23.0-60.0%, and the vertical burning grade is V-2 to V-0 grade. The invention also discloses a preparation method and application of the flame-retardant anti-dripping copolyester. Due to the introduced high-temperature self-crosslinking group and ionic group, the melt viscosity and the melt strength of the copolyester during combustion are improved, and meanwhile, the charring capacity of the copolyester is effectively enhanced, so that the copolyester disclosed by the invention shows excellent flame retardance and molten drop resistance. The preparation process of the copolyester is mature, simple and convenient to operate, easy to control and suitable for industrial production.

The invention discloses a 3D printing cellulose / nano inorganic filler composite gel ink, which is characterized in that the ink is a cellulose-based composite gel aqueous solution with a nano inorganic material as a filler and cellulose as a polymer matrix, and the ink is prepared from the following raw materials in parts by mass: 15-20 parts of nano inorganic filler dispersion liquid, 90-100 parts of cellulose dispersion liquid and 1-2 parts of chemical cross-linking agent, the addition amount of the nano inorganic filler in the nano inorganic filler dispersion liquid is 0.5-30 wt%, and the addition amount of the fiber in the cellulose dispersion liquid is 4-6 wt%. The invention also discloses a preparation method of the composite gel ink. The cellulose is used as the polymer matrix of the 3D printing ink, the preparation method is efficient, the prepared gel ink has good biocompatibility, mechanical properties and environmental friendliness, and the polymer matrix is wide in source and low in raw material cost and can be used for printing preparation of polymer reinforced composite materials in the fields of electronic devices, electronic packaging and other fields.

The invention discloses a graphene natural rubber oil-resistant mixed foaming material and a preparation method thereof. The material is prepared from the following raw materials in parts by weight: 36-44 parts of natural rubber, 28-33 parts of nitrile butadiene rubber, 8.5-11.5 parts of cis-1,4-polybutadiene rubber, 14-16 parts of polyvinyl chloride resin, 4-6 parts of white carbon black, 1.2-1.5parts of silicone oil, 1.7 to 2.1 parts of zinc oxide, 1.4 to 1.8 parts of zinc stearate, 1.3 to 1.6 parts of stearic acid, 2.3 to 2.9 parts of a cross-linking agent, 2.5 to 3.5 parts of graphene, 1.9 to 2.5 parts of a foaming agent and 1.8 to 2.4 parts of a flow aid. After being soaked in a hydrocarbon oil solvent (such as butyl acrylate), the product still maintains high tensile strength and high elongation at break, is not easy to react with the hydrocarbon oil solvent, and has good oil resistance and good mechanical properties; the compression set rate, the rebound resilience and the mechanical property are good; and wear resistance is good.

The invention relates to the technical field of photoelectric cables, and specifically discloses an ultraviolet cross-linked low-smoke, halogen-free and flame-retardant polyolefin material and a preparation method thereof. The ultraviolet cross-linked low-smoke halogen-free flame-retardant polyolefin material comprises the following raw materials: a matrix resin material, a photo-initiation cross-linking agent, a flame retardant, a processing auxiliary agent and an antioxidant, wherein a photo-crosslinking auxiliary agent in the photo-initiation cross-linking agent comprises active amine withpolymerization activity and methylene bisacrylamide. The preparation method comprises the following steps: mixing the raw materials according to a specific sequence, carrying out extrusion granulating, and carrying out ultraviolet irradiation crosslinking so as to be able to obtain the ultraviolet cross-linked low-smoke, halogen-free and flame-retardant polyolefin material. Through optimization design of a formula and a process for the ultraviolet cross-linked low-smoke, halogen-free and flame-retardant polyolefin material, ultraviolet irradiation rapid crosslinking and rapid extrusion production are realized; and the ultraviolet cross-linked low-smoke, halogen-free and flame-retardant polyolefin material has the characteristics of environmental protection, high flame retardance, aging resistance and the like.