4results about How to "Fast crosslinking" patented technology

This invention relates to an ultra-high cell density organ module based on click chemistry photocurable hydrogel, its construction method, and its applications. The construction method includes: providing norbornene-modified high molecular weight hyaluronic acid with a high grafting rate and thiol-modified high molecular weight hyaluronic acid; mixing a photoinitiator, cells, HANb solution, and HASH solution; and rapidly cross-linking and curing the module through a click chemistry reaction after extremely short-term light exposure to form the organ module. This invention utilizes the synergistic effect of the high molecular weight hyaluronic acid host material and the high grafting rate modification to achieve the construction of an ultra-high cell density organ module under ultra-low photoinitiator concentration and extremely short light exposure conditions. The liver module constructed based on this method possesses extremely high cell density, good mechanical properties, and excellent liver function.

This invention relates to a rapid film-forming repair composition, its preparation method, and its application. The rapid film-forming repair composition comprises: a rapid film-forming repair component, a film softener, a pH adjuster, a preservative, and water. The film-forming repair component includes: Suizenji nori polysaccharide, galactoarabinogalactan, and sodium dextran sulfate. The three components, Suizenji nori polysaccharide, galactoarabinogalactan, and sodium dextran sulfate, interact synergistically to promote skin improvement. Specifically, they can accelerate the formation of a film after application of the active ingredients, effectively conditioning and repairing the skin. Furthermore, they can alleviate skin inflammation and redness, and promote tissue regeneration. The rapid film-forming repair composition provided by this invention is highly suitable for use in skincare products, being gentle, non-irritating, and stable.

This invention discloses a high-temperature resistant flexible insulated cable, belonging to the field of cable technology. From the inside out, it comprises a cable core, an insulation layer, an aluminum tape, and a sheath layer. The sheath layer includes the following components: polyurethane resin, EPDM rubber, a modified copolymer, maleic anhydride-grafted EPDM rubber, mineral fiber, methyl silicone oil, silica, talc, an antioxidant, and an anti-aging agent. The high-temperature resistant flexible insulated cable provided by this invention incorporates a modified copolymer obtained through a controlled free radical polymerization process in its sheath layer. This modified copolymer is copolymerized from acrylate monomers containing sulfonate and α-aminophosphonate flame-retardant groups and hexyl acrylate. The molecular chain simultaneously integrates flame-retardant active centers and flexible compatible segments, achieving a synergistic breakthrough in compatibility, flame-retardant efficiency, and high-temperature resistance from a fundamental perspective.

This invention discloses a calcium phosphate ceramic particle-methacrylated gelatin hydrogel scaffold for osteoblasts pretreated with Tideglusib to enhance osteogenic differentiation, relating to the fields of biomedical engineering and bone tissue regeneration. It comprises osteoblasts pretreated with Tideglusib and activated, biphasic calcium phosphate ceramic particles, and a methacrylated gelatin hydrogel encapsulating the osteoblasts and ceramic particles. The preparation method includes: obtaining rat osteoblasts; seeding the osteoblasts onto the biphasic calcium phosphate ceramic particles; and pretreating the seeded biphasic calcium phosphate ceramic particles with Tideglusib solution to activate the Wnt signaling pathway and promote osteogenic differentiation. This invention exhibits excellent bone defect repair capabilities, good degradability and biocompatibility, provides necessary mechanical support, and has strong clinical translational potential.