4 results about "Thiodiethylene Glycol" patented technology

This application relates to the field of organic synthesis technology, specifically disclosing a clean synthesis method for dithiodiethylene glycol. Using β-mercaptoethanol (2-mercaptoethanol) as a starting material, this application efficiently prepares dithiodiethylene glycol via oxidative coupling. This clean synthesis method uses hydrogen peroxide as a green oxidant, achieving highly selective oxidative coupling under mild conditions. It has advantages such as simple process, high safety, environmental friendliness, easy operation, and excellent product yield, making it suitable for large-scale industrial production.

The invention relates to a gemcitabine prodrug nano assembly as well as a preparation method and application thereof, and belongs to the field of new auxiliary materials and new dosage forms of pharmaceutical preparations. The gemcitabine-vitamin E prodrug is obtained by connecting gemcitabine and vitamin E by taking thiodiglycolic anhydride as a connecting chain, and the specific structure is as shown in a general formula (I). The prodrug disclosed by the invention can construct and form a gemcitabine-vitamin E prodrug nano assembly with good self-assembly stability and chemical stability based on a Core-matured technology, and specifically releases gemcitabine in a high-oxidation environment in tumor cells, so that the curative effect of gemcitabine is effectively improved, the toxic and side effects of gemcitabine are reduced, and the preparation method is suitable for clinical application. And a new strategy and choice are provided for developing a high-efficiency and low-toxicity chemotherapy preparation.

The application belongs to the technical field of biological medicine, and particularly relates to an N,N-dimethylethylene diamine-thiodiglycolic acid monocholesteryl ester conjugate as well as a preparation method and application thereof. The structural formula of the N,N-dimethylethylene diamine-thiodiglycolic acid monocholesteryl ester conjugate is as follows: first, cholesteryl and thiodiglycolic anhydride are dissolved together, N,N-dimethylaminopyridine is added, and a reflux reaction is performed to obtain thiodiglycolic acid monocholesteryl ester; then, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride is dissolved together, N,N-dimethylethylene diamine is added, and a reaction is performed to obtain a conjugate molecule. The conjugate is blended with lecithin to serve as a cationic liposome. By adjusting the ratio of lecithin and the conjugate, the particle size and potential of the cationic liposome can be adjusted.

The invention discloses a preparation process of thiodimercaptan, which comprises the following steps: introducing thiodiglycol and hydrogen sulfide into a mixer, then feeding into a reactor filled with a catalyst, separating the product and unreacted hydrogen sulfide after the reaction is finished, and preparing thiodimercaptan by replacing more components in the current reaction process with hydrogen sulfide, so that the process line is simple, the operation is simple, and the production cost is low. The invention further discloses a catalyst, in the preparation process of the catalyst, F127 serves as a template agent, citric acid serves as a complexing agent, hydrochloric acid serves as a catalyst, aluminum isopropoxide serves as an aluminum source, and the porous aluminum oxide loaded cobalt catalyst is prepared in an in-situ generation mode. The porous structure of the carrier can increase the contact area and further catalyze and improve the reaction rate.