The invention belongs to the technical field of medicines, and particularly discloses an
emodin solid dispersion as well as a preparation method and application thereof. The
emodin solid dispersion disclosed by the invention is obtained by mixing
emodin, a
high polymer carrier and a bonding agent and then treating through a
hot melt extrusion technology, and the
drug loading capacity of the emodin
solid dispersion is 5-20%. Through Lewis acid-base and
hydrogen-bond interaction, an emodin molecular
dimer structure is broken, so that an amorphous
drug is in a supersaturated state; meanwhile, the emodin solid dispersion
system is relatively low in
Gibbs free energy and molecular mobility and relatively strong in
intermolecular interaction, so that the
physical stability of the amorphous preparation is enhanced, and the in-vitro
dissolution of the amorphous preparation is prolonged; according to the emodin solid dispersion and the preparation method thereof, no
organic solvent is used, the preparation is safe and efficient, the obtained emodin solid dispersion improves the
dissolution rate and
solubility of insoluble drugs, the
drug loading capacity is high, the stability is good, a good intermediate is provided for other oral solid preparations of emodin, and the preparation process is simple, efficient, safe and suitable for industrial production.